A5087831877- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
Leibniz Institute for Resilience Research
2022
University Medical Center of the Johannes Gutenberg University Mainz
2022
Johannes Gutenberg University Mainz
2020-2022
University Medical Center
2020
Chronic social defeat (CSD) can lead to impairments in interaction and other behaviors that are supposed model features of major depressive disorder (MDD). Not all animals subjected CSD, however, develop these impairments, maintained some is widely used as a for resilience stress-induced mental dysfunctions. So far, have mainly been studied shortly (24 hours 7 days) after CSD exposure longitudinal development behavioral phenotypes individual has mostly neglected. We analyzed novel object...
Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-term mental dysfunction. The underlying molecular mechanisms are complex and have not yet been fully understood. In this study, we performed data-driven behavioural stratification together with single-cell transcriptomics the hippocampus in mouse model social defeat stress. Our work revealed that sub-group exhibiting responses upon dorsal is particularly involved neuroimmune responses,...
Abstract Chronic social defeat (CSD) can lead to impairments in interaction and other behaviors that are supposed model features of major depressive disorder (MDD). Not all animals subjected CSD, however, develop these impairments, maintained some is widely used as a for resilience stress-induced mental dysfunctions. So far, have mainly been studied shortly (24 hours 7 days) after CSD exposure longitudinal development behavioral phenotypes individual has mostly neglected. We analyzed novel...
Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-term mental dysfunction. The underlying molecular mechanisms are complex and have not yet been fully understood. In this study, we performed data-driven behavioural stratification together with single-cell transcriptomics the hippocampus in mouse model social defeat stress. Our work revealed that sub-group exhibiting adaptive responses upon dorsal is particularly involved neuroimmune responses,...