A5077943882- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Electroconvulsive Therapy Studies
- Blood disorders and treatments
- Mental Health Treatment and Access
- Mental Health Research Topics
- Psychiatric care and mental health services
- Child and Adolescent Psychosocial and Emotional Development
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Cannabis and Cannabinoid Research
- Health Systems, Economic Evaluations, Quality of Life
- Epigenetics and DNA Methylation
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Cardiac electrophysiology and arrhythmias
- Treatment of Major Depression
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Cardiovascular Syncope and Autonomic Disorders
- Immunodeficiency and Autoimmune Disorders
King's College London
2016-2025
South London and Maudsley NHS Foundation Trust
2015-2024
Mental Health Foundation
2023-2024
National Institute for Health Research
2017-2023
Centre for Mental Health
2020-2022
Oslo University Hospital
2022
National Institute of Mental Health
2022
Bethlem Royal Hospital
2014-2022
The London College
2022
NIHR Maudsley Dementia Biomedical Research Unit
2018-2022
These updated guidelines from the British Association for Psychopharmacology replace original version published in 2011. They address scope and targets of pharmacological treatment schizophrenia. A consensus meeting was held 2017, involving experts schizophrenia its treatment. were asked to review key areas consider strength evidence on risk-benefit balance interventions clinical implications, with an emphasis meta-analyses, systematic reviews randomised controlled trials where available,...
<h3>Context</h3>Preterm birth, intrauterine growth restriction, and delivery-related hypoxia have been associated with schizophrenia. It is unclear whether these associations pertain to other adult-onset psychiatric disorders perinatal events are independent.<h3>Objective</h3>To investigate the relationships among gestational age, nonoptimal fetal growth, Apgar score, various in young adult life.<h3>Design</h3>Historical population-based cohort study.<h3>Setting</h3>Identification of...
Cannabis use is associated with an earlier age of onset psychosis (AOP). However, the reasons for this remain debated. Methods: We applied a Cox proportional hazards model to 410 first-episode patients investigate association between gender, patterns cannabis use, and AOP. Results: Patients history presented their first episode at younger (mean years = 28.2, SD 8.0; median 27.1) than those who never used 31.4, 9.9; 30.0; hazard ratio [HR] 1.42; 95% CI: 1.16–1.74; P < .001). This remained...
Anecdotal and biographical reports suggest that bipolar disorder may be associated with high IQ or creativity, but evidence for any such connection is weak.To investigate possible associations between scholastic achievement later disorder, using prospective data, in a whole-population cohort study.Using individual school grades from all individuals finishing compulsory schooling Sweden 1988 1997, we tested at age 15-16 hospital admission psychosis ages 17 31, adjusting potential...
It is unknown how genetic variants conferring liability to psychiatric disorders survive in the population despite strong negative selection. However, this key understanding their etiology and designing studies identify risk variants.To examine reproductive fitness of patients with schizophrenia other vs unaffected siblings evaluate level selection on causal variants.We measured fecundity schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse compared...
Background Clozapine remains the only evidence-based antipsychotic for treatment-resistant schizophrenia (TRS). The ability to predict which patients with their first onset of would subsequently meet criteria treatment resistance (TR) could help diminish severe functional disability may ensue if TR is not recognized and correctly treated. Method This a 5-year longitudinal assessment clinical outcomes in cohort 246 first-episode spectrum recruited as part NIHR Genetics Psychosis (GAP) study...
Background We examined longitudinally the course and predictors of treatment resistance in a large cohort first-episode psychosis (FEP) patients from initiation antipsychotic treatment. hypothesized that is: ( ) present at illness onset; b differentially associated with clinical demographic factors. Method The study sample comprised 323 FEP who were studied first contact 10-year follow-up. collated information on severity symptoms, medication adherence during follow-up period to determine...
<h3>Importance</h3> Previous in vitro and postmortem research suggests that inflammation may lead to structural brain changes via activation of microglia and/or astrocytic dysfunction a range neuropsychiatric disorders. <h3>Objective</h3> To investigate the relationship between structures vivo explore transcriptome-driven functional basis with relevance mental illness. <h3>Design, Setting, Participants</h3> This study used multistage linked analyses, including mendelian randomization (MR),...
With the ongoing coronavirus disease 2019 (COVID-19) pandemic, psychiatrists find themselves in clinical situation of being asked by patients, family members and patient advocacy societies to help ensure access clozapine as a medication critical for care. To provide
<h3>Importance</h3> About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as<i>treatment-resistant schizophrenia</i>(TRS). The causes treatment resistance their relationships underlying are largely unknown. Adequately powered genetic studies TRS scarce because the difficulty in collecting data from well-characterized cohorts. <h3>Objective</h3>...
It is unclear whether schizophrenia and psychotic bipolar disorder are associated with similar deviations of brain morphometry.To assess volumetric abnormalities grey white matter throughout the entire in individuals or compared same control group.Brain scans were obtained by magnetic resonance imaging from 25 people schizophrenia, 37 who had experienced symptoms 52 healthy volunteers. Regional deviation volume was assessed using computational morphometry.Individuals distributed deficit...
The debate endures as to whether schizophrenia and bipolar disorder are separate entities or different manifestations of a single underlying pathological process. Here, we argue that this sterile argument obscures the fact truth lies somewhere in between. Thus, recent studies support model whereby, on background some shared genetic liability for both disorders, patients with have been subject additional and/or environmental factors impair neurodevelopment; example, copy number variants...
<h3>Importance</h3> At least 11 rare copy number variants (CNVs) have been shown to be major risk factors for schizophrenia (SZ). These CNVs also increase the other neurodevelopmental disorders, such as intellectual disability. It is possible that additional disability–associated SZ but not yet implicated in because of previous studies being underpowered. <h3>Objective</h3> To examine whether disability represent novel loci. <h3>Design, Setting, and Participants</h3> We used...