A5078401685- Schizophrenia research and treatment
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Mental Health and Psychiatry
- Neurotransmitter Receptor Influence on Behavior
- Electroconvulsive Therapy Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Mental Health Treatment and Access
- Psychiatric care and mental health services
- Psychosomatic Disorders and Their Treatments
- Advanced Neuroimaging Techniques and Applications
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Epilepsy research and treatment
- Morphological variations and asymmetry
- Patient Satisfaction in Healthcare
- HIV-related health complications and treatments
- Regulation of Appetite and Obesity
General Dynamics (United States)
2016-2024
CHI Health Creighton University Medical Center - Bergan Mercy
2023
Creighton University
2022
Queen's University Belfast
2007-2020
Royal College of Psychiatrists
2014-2019
Newcastle University
2011
Queen's University
2011
Bridge University
2011
Marymount University
2010-2011
Mater Misericordiae University Hospital
2010-2011
These updated guidelines from the British Association for Psychopharmacology replace original version published in 2011. They address scope and targets of pharmacological treatment schizophrenia. A consensus meeting was held 2017, involving experts schizophrenia its treatment. were asked to review key areas consider strength evidence on risk-benefit balance interventions clinical implications, with an emphasis meta-analyses, systematic reviews randomised controlled trials where available,...
Excess deaths from cardiovascular disease are a major contributor to the significant reduction in life expectancy experienced by people with schizophrenia. Important risk factors this smoking, alcohol misuse, excessive weight gain and diabetes. Weight also reinforces service users' negative views of themselves is factor poor adherence treatment. Monitoring relevant physical health frequently inadequate, as provision interventions modify these. These guidelines review issues surrounding...
Background In the UK and other high-income countries, life expectancy in people with schizophrenia is 20% lower than general population. Aims To examine quality of assessment treatment physical health problems schizophrenia. Method Retrospective audit records or schizoaffective disorder aged ⩾18. We collected data on nine key aspects for 5091 patients combined these a cross-sectional patient survey. Results Body mass index was recorded 2599 (51.1%) during previous 12 months 1102 (21.6%) had...
Anomalies of structure and asymmetry the parahippocampal gyrus (origin perforant path input to hippocampal formation in medial temporal lobe) have been shown some postmortem studies schizophrenia, but previous not included fusiform (which may a role facial recognition naming), adjacent on ventral occipitotemporal surface.The volumes gray matter left right gyri were assessed with stereological point-counting technique lobes from formalin-fixed brains 27 comparison subjects 31 patients...
Objective: To examine the cardiovascular and respiratory health of people with severe mental illness (SMI) compare findings Health Surveys for England. Method: A prospective, multi‐centre observational prevalence study 602 patients schizophrenia‐related psychoses carried out in six locations across UK over 24 months. Results: Compared general population subjects, SMI reported higher rates angina symptoms had poor lung function. Much this increased risk could be explained by lifestyle...
Among 16 chronic schizophrenic in-patients, all had at least one neurological soft sign (NSS), and 6 (40%) definite neurodysfunction. NSS TD scores were highly intercorrelated, significantly correlated with neuroleptic drug exposure. positively both positive negative symptoms cognitive impairment but not cerebral ventricular size on CT. Patients neurodysfunction more psychopathology, than those without. Cerebral sizes family histories of schizophrenia similar in groups. The presence may be a...
Substance misuse is a common comorbid problem in people presenting with first-episode psychosis and associated poor short-term outcome.The aim of this study to examine differences baseline characteristics 1-year outcome between individuals who have never misused substances, those stop misusing substances after initial presentation persistently over the assessment period.Patients were recruited Northern Ireland First Episode Psychosis Study (n = 272). Clinical assessments performed at 1 year...
A history of childhood trauma is common in individuals who later develop psychosis. Similar neuroanatomical abnormalities are observed people have been exposed to and with However, the relationship between such psychosis has not investigated. This study aimed explore association experience hippocampal amygdalar volumes a first-episode (FEP) population.The employed an observational retrospective design. Twenty-one individuals, had previously undergone magnetic resonance imaging procedures as...
Obesity and metabolic syndrome are significant problems for patients taking antipsychotic drugs. Evidence is emerging of genetic risk factors.To investigate the influence two candidate genes, smoking drug treatment on obesity in with schizophrenia.Patients (n=134) were assessed measures obesity, other factors contributing to syndrome, polymorphisms (5-HT(2C) receptor -759C/T leptin -2548A/G).Neither genotype nor was significantly associated obesity. However, both syndrome. Significant...
Researching psychotic disorders in unison rather than as separate diagnostic groups is widely advocated, but the viability of such an approach requires careful consideration from a neurocognitive perspective.To describe cognition people with bipolar disorder and schizophrenia to examine how known causes variability individual's performance contribute any observed differences.Neurocognitive functioning (n = 32), 46) healthy controls 67) was compared using analysis covariance on data Northern...
Depression is a frequently occurring symptom in schizophrenia. While today it often underrecognised and under-treated, historically such symptoms were the focus of much attention. Affective used by Kraepelin as an important criterion with which to separate dementia praecox from manic–depressive illness. also recognised importance depression schizophrenia identified several depressive subtypes Mayer-Gross emphasised despair that occurs psychological reaction acute psychotic episodes Bleuler...
Low plasma folate and its derivatives have been linked with depressive disorders in studies dating back over 30 years. A thermolabile variant (677C>T) of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated low serum folate. The present study aimed to explore whether MTHFR a vulnerability episodes. C677T genotype frequencies cohort patients (mean age 48 years) disorder ( n = 100) were compared those age- sex-matched controls. Serum levels folate, homocysteine vitamin...