A5017525685- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Pharmacological Effects and Toxicity Studies
- Treatment of Major Depression
- Neurological and metabolic disorders
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Obsessive-Compulsive Spectrum Disorders
- Pharmaceutical studies and practices
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Botulinum Toxin and Related Neurological Disorders
- Cancer Treatment and Pharmacology
- Health Systems, Economic Evaluations, Quality of Life
- Metabolism and Genetic Disorders
- Cannabis and Cannabinoid Research
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Parkinson's Disease and Spinal Disorders
- Tryptophan and brain disorders
Royal College of Psychiatrists
2012-2024
Imperial College London
2015-2024
RaNA Therapeutics (United States)
2022-2023
North Carolina State University
2023
Centre for Mental Health
2011-2022
University of California, San Diego
2022
Queen's Medical Centre
2022
University of Nottingham
2000-2022
Victoria University of Wellington
2022
McLean Hospital
2022
A rating scale for drug-induced akathisia has been derived that incorporates diagnostic criteria pseudoakathisia, and mild, moderate, severe akathisia. It comprises items the observable, restless movements which characterise condition, subjective awareness of restlessness, any distress associated with In addition, there is an item global severity. standard examination procedure recommended. The inter-rater reliability (Cohen's x ) ranged from 0.738 to 0.955. Akathisia was found in eight 42...
Second-generation (atypical) antipsychotics (SGAs) are more expensive than first-generation (typical) (FGAs) but perceived to be effective, with fewer adverse effects, and preferable patients. Most evidence comes from short-term efficacy trials of symptoms.To test the hypothesis that in people schizophrenia requiring a change treatment, SGAs other clozapine associated improved quality life across 1 year compared FGAs.A noncommercially funded, pragmatic, multisite, randomized controlled trial...
<h3>Background</h3> Research evidence supports the efficacy of cognitive-behavioral therapy in treatment drug-refractory positive symptoms schizophrenia. Although cumulative is strong, early controlled trials showed methodological limitations. <h3>Methods</h3> A randomized design was used to compare manualized developed particularly for schizophrenia with that a nonspecific befriending control intervention. Both interventions were delivered by 2 experienced nurses who received regular...
These updated guidelines from the British Association for Psychopharmacology replace original version published in 2011. They address scope and targets of pharmacological treatment schizophrenia. A consensus meeting was held 2017, involving experts schizophrenia its treatment. were asked to review key areas consider strength evidence on risk-benefit balance interventions clinical implications, with an emphasis meta-analyses, systematic reviews randomised controlled trials where available,...
There is good evidence that clozapine more efficacious than first-generation antipsychotic drugs in resistant schizophrenia. It less clear if effective the other second-generation (SGA) drugs. A noncommercially funded, pragmatic, open, multisite, randomized controlled trial was conducted United Kingdom National Health Service (NHS). Participants were 136 people aged 18–65 with DSM-IV schizophrenia and related disorders whose medication being changed because of poor clinical response to 2 or...
BackgroundImproved management of mental illness and substance misuse comorbidity is a National Health Service priority, but little known about its prevalence current management.AimsTo measure the among patients community health teams (CMHTs) services, to assess potential for joint management.MethodCross-sectional survey in four urban UK centres.ResultsOf CMHT patients, 44% (95% CI 38.1-49.9) reported past-year problem drug use and/or harmful alcohol use; 75% 68.2-80.2) service 85% 74.2-931)...
These guidelines from the British Association for Psychopharmacology address scope and targets of pharmacological treatment schizophrenia. A consensus meeting, involving experts in schizophrenia its treatment, reviewed key areas considered strength evidence clinical implications. The were drawn up after extensive feedback participants interested parties, cover management across various stages illness, including first-episode, relapse prevention, illness that has proved refractory to standard...
<b>Objectives</b> To evaluate the clinical effectiveness of group art therapy for people with schizophrenia and to test whether any benefits exceed those an active control treatment. <b>Design</b> Three arm, rater blinded, pragmatic, randomised controlled trial. <b>Setting</b> Secondary care services across 15 sites in United Kingdom. <b>Participants</b> 417 aged 18 or over, who had a diagnosis provided written informed consent take part study. <b>Interventions</b> Participants, stratified...
Background. We tested the hypothesis that schizophrenia is primarily a frontostriatal disorder by examining executive function in first-episode patients. Previous studies have shown either equal decrements many cognitive domains or specific deficits memory. Such grouped test results used few measures, thus, possibly losing information. We, therefore, measured range of ability with tests known to be sensitive frontal lobe function.Methods. Thirty schizophrenic patients and 30 normal...
Substance use may be a risk factor for the onset of schizophrenia.To examine association between substance and age at in UK, inner-city sample people with recent-onset schizophrenia.The study consisted 152 recruited to West London First-Episode Schizophrenia Study. Self-reported data on drug alcohol use, as well information psychosis, were collected. Mental state, cognition (IQ, memory executive function) social function also assessed.In total, 60% participants smokers, 27% reported history...
• Eighty-two schizophrenic outpatients receiving maintenance antipsychotic medication were assessed for akathisia and tardive dyskinesia. Thirty-nine (48%) manifested patterns of nondyskinetic, restless movement characteristic akathisia. On the basis their clinical features, these patients divided into three groups: "acute" (recent onset, related to an increase in drug dose); "pseudoakathisia" (motor signs but no subjective symptoms); "chronic" (a mixed category including persistent acute...
Background It has been suggested that some psychotic symptoms reflect ‘aberrant salience’, related to dysfunctional reward learning. To test this hypothesis we investigated whether patients with schizophrenia showed impaired learning of task-relevant stimulus–reinforcement associations in the presence distracting task-irrelevant cues. Method We tested 20 medicated and 17 controls on a reaction time game, Salience Attribution Test. In participants made speeded response earn money conditioned...
Assessment of drug-induced movement disorders was carried out regularly on 104 psychiatric patients requiring antipsychotic medication admission to hospital. The data relevant motor restlessness were subjected a principal components' analysis. According their component scores, then classified into two main groups: an akathisia group and illness-related-movement group, the former showing clinical pharmacological characteristics expected akathisia. Clinical features which distinguished between...
Three adult subjects were taught a set of two‐choice simultaneous discriminations, with three positive and negative stimuli; all possible combinations stimuli yielded nine different pairs. The discriminations repeatedly reversed rereversed, the former becoming positive. With subjects, reversal contingencies for one pair became sufficient to change their responses other reversals had produced functional stimulus classes. Then, showed conditional emerging between members class; given sample...
The HTA Programme was set up in 1993.Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies produced most efficient way for those who use, manage provide care NHS.'Health technologies' are broadly defined include all interventions used promote health, prevent treat disease, improve rehabilitation long-term care, rather than settings care.The commissions only topics where it has identified key gaps evidence needed by...
The intradimensional/extradimensional (IDED) task assesses different forms of learning from feedback. Limited evidence suggests that attentional set-shifting deteriorates over time in schizophrenia. We tested this hypothesis and examined the specificity impairments identified by task.Two hundred sixty-two first-episode patients 76 healthy control subjects, matched for age premorbid IQ, were tested; 104 25 subjects reassessed 1 3 years later, 31 additionally 6 later.Patients showed impaired...
Background Studies in schizophrenia suggest that a longer initial period of untreated illness is associated with poorer clinical outcome. Aims To determine whether, first-episode schizophrenia, duration psychosis (DUP) or (DUI) (DUP plus any prodrome) variables could mediate poor prognosis. Method Clinical, social, neuropsychological and oculomotor function data on 53 patients were related to the DUP DUI. Results Comparing short long groups split around median showed no statistically...