Siân Lowri Griffiths
A5089781792- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Health Policy Implementation Science
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Mental Health and Patient Involvement
- Health disparities and outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Machine Learning in Healthcare
- Health, psychology, and well-being
- Attention Deficit Hyperactivity Disorder
- Employment and Welfare Studies
- Dementia and Cognitive Impairment Research
- Psychosomatic Disorders and Their Treatments
- Delphi Technique in Research
- Amyotrophic Lateral Sclerosis Research
- Chronic Disease Management Strategies
- Hallucinations in medical conditions
- Health, Environment, Cognitive Aging
Institute of Mental Health
2023-2025
University of Birmingham
2012-2025
Centre for Mental Health
2020-2023
Ludwig-Maximilians-Universität München
2023
People exposed to more unfavourable social circumstances are vulnerable poor mental health over their life course, in ways that often determined by structural factors which generate and perpetuate intergenerational cycles of disadvantage health. Addressing these challenges is an imperative matter justice. In this paper we provide a roadmap address the determinants cause ill Relying as far possible on high-quality evidence, first map out literature supports causal link between later outcomes....
<h3>Importance</h3> Previous in vitro and postmortem research suggests that inflammation may lead to structural brain changes via activation of microglia and/or astrocytic dysfunction a range neuropsychiatric disorders. <h3>Objective</h3> To investigate the relationship between structures vivo explore transcriptome-driven functional basis with relevance mental illness. <h3>Design, Setting, Participants</h3> This study used multistage linked analyses, including mendelian randomization (MR),...
<h3>Importance</h3> The behavioral and cognitive symptoms of severe psychotic disorders overlap with those seen in dementia. However, shared brain alterations remain disputed, their relevance for patients at-risk disease stages has not been explored so far. <h3>Objective</h3> To use machine learning to compare the expression structural magnetic resonance imaging (MRI) patterns behavioral-variant frontotemporal dementia (bvFTD), Alzheimer (AD), schizophrenia; estimate predictability bvFTD...
Studies investigating cognitive impairments in psychosis and depression have typically compared the average performance of clinical group against healthy controls (HC), do not report on actual prevalence or strengths within these groups. This information is essential so that services can provide adequate resources to supporting functioning. Thus, we investigated this individuals early course depression.A comprehensive test battery comprising 12 tests was completed by 1286 aged 15-41 (mean...
Treatment resistance causes significant burden in psychosis. Clozapine is the only evidence-based pharmacologic intervention available for people with treatment-resistant schizophrenia; current guidelines recommend commencement after two unsuccessful trials of standard antipsychotics.This paper aims to explore prevalence treatment and pathways clozapine UK early psychosis (EIP) services.Data were taken from National Evaluation Development Impact Early Intervention Services study (N = 1027)...
Abstract Diagnostic heterogeneity within and across psychotic affective disorders challenges accurate treatment selection, particularly in the early stages. Delineation of shared distinct illness features at phenotypic brain levels may inform development more precise differential diagnostic tools. We aimed to identify prototypes depression psychosis investigate their heterogeneity, with common, comorbid transdiagnostic symptoms. Analyzing clinical/neurocognitive grey matter volume (GMV) data...
Abstract In schizophrenia, neurocognitive subtypes can be distinguished based on cognitive performance and they are associated with neuroanatomical alterations. We investigated the existence of in shortly medicated recent onset psychosis patients, their underlying gray matter volume patterns clinical characteristics. used a K-means algorithm to cluster 108 patients from multi-site EU PRONIA (Prognostic tools for early management) study validated solution independently ( N = 53). Cognitive...
Abstract Early psychosis is characterised by heterogeneity in illness trajectories, where outcomes remain poor for many. Understanding symptoms and their relation to outcomes, from a novel network perspective, may help delineate psychopathology within early identify pivotal targets intervention. Using modelling first episode (FEP), this study aimed identify: (a) key central bridge most influential symptom networks, (b) examine the structure stability of networks at baseline 12-month...
BackgroundChronic low-grade inflammation is observed across mental disorders and associated with difficult-to-treat-symptoms of anhedonia functional brain changes – reflecting a potential transdiagnostic dimension. Previous investigations have focused on distinct illness categories in those enduring illness, few exploring inflammatory changes. We sought to identify an signal function underlying among young people recent onset psychosis (ROP) depression (ROD).MethodResting-state magnetic...
At-Risk Mental State (ARMS) services aim to prevent the onset of first-episode psychosis (FEP) in those with specific clinical or genetic risk markers. In England, ARMS are currently expanding, but accessibility this preventative approach remains questionable, especially for a subgroup FEP patients and from ethnic minority communities. This commentary outlines key debates about why complimentary prevention is necessary, gives details an innovative public health strategy, drawing on existing...
BACKGROUND: Specific cognitive impairments are common in major depressive disorder, impacting functioning and quality of life. However, the longitudinal course depression is unclear. AIMS: This study aimed to determine following a recent onset depression, as compared healthy controls. METHODS: Healthy controls individuals experiencing (within two years) were recruited across ten European sites, completing baseline nine-month follow-up clinical, demographic, assessment for PRONIA study....
Introduction Evidence suggests a potentially causal role of interleukin 6 (IL-6), pleiotropic cytokine that generally promotes inflammation, in the pathogenesis psychosis. However, no interventional studies patients with psychosis, stratified using inflammatory markers, have been conducted to assess therapeutic potential targeting IL-6 psychosis and elucidate mechanism effect. Tocilizumab is humanised monoclonal antibody receptor inhibit signalling, licensed UK for treatment rheumatoid...
Abstract Cognitively impaired and spared patient subgroups were identified in psychosis depression, clinical high-risk for (CHR). Studies suggest differences underlying brain structural functional characteristics. It is unclear whether cognitive are transdiagnostic phenomena early stages of psychotic affective disorder which can be validated on the neural level. Patients with recent-onset (ROP; N = 140; female 54), depression (ROD; 130; 73), CHR ( 128; 61) healthy controls (HC; 270; 165)...
Purpose Researcher mental health in emotionally demanding research (EDR) has been recognized as important, but to date often limited academic contexts, qualitative research, or single disciplines. The aim of this study was identify best practices promote researchers' EDR across and non-academic contexts.
Background While cognitive impairment is a core feature of psychosis, significant heterogeneity in and clinical outcomes observed. Aims The aim this study was to identify subgroups first-episode psychosis (FEP) determine if these profiles were linked functional over time. Method A total 323 individuals with FEP included. Two-step hierarchical k -means cluster analyses performed using baseline variables. General linear mixed models used investigate whether clusters associated functioning at...
Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup showing prominent severity, neurocognitive impairments. This study aimed to identify stable generalizable FTD-subgroups recent-onset psychosis (ROP) by applying comprehensive data-driven clustering approach test validity these subgroups assessing associations...
Abstract Psychosocial disability affects a number of individuals with psychosis and often begins years before the formal onset disorder. This suggests that for many, their psychosocial is enduring, targeted interventions are therefore needed earlier in developmental trajectories to ensure does not become entrenched. Poor functioning also range different emerging mental health problems, putting these young people at risk long-term social marginalisation economic disadvantage; all which known...
Abstract Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression seen primarily a distinct subgroup, which if identified could allow targeted treatments. We hypothesize patients with recent-onset (ROP) comorbid would be identifiable by symptoms neuroanatomical features similar to those (ROD). Data were extracted from the multisite PRONIA study: 154 ROP (FEP within 3 months of treatment onset), whom 83...
Abstract Cannabis use during adolescence is associated with an increased risk of developing psychosis. According to a current hypothesis, this results from detrimental effects early cannabis on brain maturation vulnerable period. However, studies investigating the interaction between and structural alterations hitherto reported inconclusive findings. We investigated age initiation psychosis using data multicentric Personalized Prognostic Tools for Early Psychosis Management (PRONIA) Induced...