A5061469818- Schizophrenia research and treatment
- Mental Health Research Topics
- Mental Health and Psychiatry
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacovigilance and Adverse Drug Reactions
- Olfactory and Sensory Function Studies
- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Neuroscience and Music Perception
- melanin and skin pigmentation
- Mental Health Treatment and Access
- Psychiatric care and mental health services
- Neurobiology and Insect Physiology Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Delphi Technique in Research
- Statistical Methods in Clinical Trials
- Meta-analysis and systematic reviews
- Pharmaceutical studies and practices
- Computational Drug Discovery Methods
- Psychotherapy Techniques and Applications
Amsterdam UMC Location University of Amsterdam
2019-2024
Dimence
2021-2024
Amsterdam University Medical Centers
2020-2024
University of Amsterdam
2021
Reinier van Arkel
2020
Arkin
2020
University Medical Center
2016-2020
University Hospital and Clinics
2016
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016
Abstract Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from EU-GEI study, we evaluated impact schizophrenia polygenic risk score (SZ-PRS) and patterns cannabis use on transdiagnostic We analysed first-episode psychosis patients (FEP) controls, generating dimensions psychotic symptoms experiences using item response bi-factor modelling. Linear regression was used to test associations between these SZ-PRS, as well combined effect SZ-PRS...
Clinical staging of schizophrenia entails a new method that identifies clusters symptoms and variation in level remission, with the goal to create framework for early intervention. Additionally, duration untreated psychosis (DUP) may influence symptom severity first episode (FEP) could necessitate refining model. However, consistent evidence concerning DUP between stages is missing. Therefore, we evaluated clinical validity model by investigating differences across spectrum disorders....
Abstract Background and Hypothesis Recovering from a first psychosis is highly individual process requires the person to make sense of their experiences. Clinicians, in turn, need comprehend these first-person perspectives, creating mutual sense-making dynamic. Antipsychotic medication substantial part treatment. Providing insight lived experience recovery with antipsychotics could improve understanding help bridge gap between perspective clinician that recovering psychosis. Study Design 14...
clinical staging and profiling of schizophrenia spectrum disorders has been proposed to describe define the heterogenous course disease. We examined construct validity in by measuring differences distribution severity relevant profilers therapeutic improvement (HoNOS) across stages.
Clinical staging and profiling have been proposed as a new approach in order to refine the diagnostic assessment of schizophrenia spectrum disorders. However, only limited evidence is available for inter-rater reliability clinical model. The aim present study was therefore determine model disorders, investigate whether short course can improve reliability. Consecutively recruited inpatients with disorders were included between January 2015 2016 (study 1), March 2018 October 2). By contrast...
El bulbo y pedúnculo olfatorio humano contienen muchos grupos celulares más o menos separados que habitualmente son considerados como parte del núcleo anterior retro-bulbar (AON). La presunción estos sean extensión rostral AON en el hemisferio retrocede a la descripción de un único caso por Crosby Humphrey (1941). Para mejorar nuestra comprensión anatomía bulbar peduncular investigamos morfología, forma tamaño estas partes este tejido post-mortem individuos edades conocidas. Se obtuvieron...
Clinical staging has been developed to capture the large heterogeneity in schizophrenia spectrum disorders. Including cognitive performance model may improve its clinical validity. Moreover, functioning could predict transition across stages. However, current evidence of association between cognition and is inconsistent. Therefore, we aim assess whether parameters are associated with stages a sample patients disorders identify markers at baseline that stage-transition three six-year...
Antidepressant trials are criticized due to potential methodological flaws. Root causes of failing methodology can be found in insufficient inter-rater reliability (IRR) and training practices, leading higher placebo response reduced study-power. However, it is unknown what extent estimates or procedures currently included antidepressant reports. Therefore, we aimed determine the proportion publications concerning double-blind randomized controlled that report on IRR coefficients...
Abstract Objectives Profile characteristics are factors that relevant for diagnosis, prognosis or treatment. The present study aims to develop a set of clinically profile characteristics. Moreover, our goal is determine the inter‐rater reliability (IRR) selected Methods Potential were determined by literature review. Assessment IRR was done comparing scores on two researchers. We conducted three subsequent studies: (1) assessment pre‐training IRR, (2) following implementation an instruction...