Edoardo Spinazzola
A5076409911- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 and Mental Health
- Genetic Associations and Epidemiology
- Mental Health Treatment and Access
- Homelessness and Social Issues
- Psychosomatic Disorders and Their Treatments
- Long-Term Effects of COVID-19
- Neurotransmitter Receptor Influence on Behavior
- Health disparities and outcomes
- Child Abuse and Trauma
- Tryptophan and brain disorders
- Psychedelics and Drug Studies
- Substance Abuse Treatment and Outcomes
- Face Recognition and Perception
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Healthcare Decision-Making and Restraints
- GABA and Rice Research
- COVID-19 and healthcare impacts
- Sexuality, Behavior, and Technology
- Maternal Mental Health During Pregnancy and Postpartum
- Obsessive-Compulsive Spectrum Disorders
Mental Health Foundation
2024-2025
King's College London
2019-2025
South London and Maudsley NHS Foundation Trust
2023-2025
Health Foundation
2023
Sapienza University of Rome
2017-2022
Volumetric studies on deep gray matter structures in bipolar disorder (BP) have reported contrasting results. Childhood trauma, a relevant environmental stressor for BP, could account the variability of results, modulating differences amygdala and hippocampus patients with BP compared healthy controls (HC). Our study aimed to test this hypothesis.We assessed 105 outpatients, diagnosed type I (BP-I) or II (BP-II) according DSM-IV-TR criteria, 113 HC subjects. History childhood trauma was...
Abstract Background Schizophrenia (SZ), bipolar disorder (BD) and depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects the associated variants can be summarised as polygenic risk score (PRS). Using data from EUropean Network national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) first episode case–control study, we aimed test whether PRSs for...
1. Introduction The spread of laws legalising cannabis for medicinal or recreational use has been accompanied by more relaxed attitudes towards cannabis. Data from the United States show that in states have legalised cannabis, prevalence daily, weekly, and monthly was 11.3%, 18.3%, 25.0% respectively, whereas countries where it is still illegal, lower (7.4%, 11.6%, 16.8% respectively).46 Evidence indicates a trend increase among adolescents,58 particular vulnerable category initiation...
To establish whether the risk of psychotic disorders in cannabis users changes with time following cessation using data from European Network National Networks studying Gene-Environment Interactions Schizophrenia (EU-GEI) case-control study. The EU-GEI study collected first episode psychosis patients and population controls across sites Europe Brazil between May 2010 April 2015. Adjusted logistic regressions were applied to examine odd case status changed: (1) (2) different use groups....
Abstract Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from EU-GEI study, we evaluated impact schizophrenia polygenic risk score (SZ-PRS) and patterns cannabis use on transdiagnostic We analysed first-episode psychosis patients (FEP) controls, generating dimensions psychotic symptoms experiences using item response bi-factor modelling. Linear regression was used to test associations between these SZ-PRS, as well combined effect SZ-PRS...
Abstract Background Incidence of first-episode psychosis (FEP) varies substantially across geographic regions. Phenotypes subclinical (SP), such as psychotic-like experiences (PLEs) and schizotypy, present several similarities with psychosis. We aimed to examine whether SP measures varied different sites this variation was comparable FEP incidence within the same areas. further examined contribution environmental genetic factors SP. Methods used data from 1497 controls recruited in 16 6...
Abstract Background Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of may be acting as mediator between psychotic disorders has not yet been explored. The aim this study is to examine mediates the relationship childhood psychosis. Methods Data were utilised on 881 first-episode psychosis patients 1231 controls from European network national schizophrenia networks studying Gene–Environment Interactions (EU-GEI) study....
Abstract Background Multiple genetic and environmental risk factors play a role in the development of both schizophrenia-spectrum disorders affective psychoses. How they act combination is yet to be clarified. Methods We analyzed 573 first episode psychosis cases 1005 controls, European ancestry. Firstly, we tested whether association polygenic scores for schizophrenia, bipolar disorder, depression (PRS-SZ, PRS-BD, PRS-D) with disorder differed when participants were stratified by exposure...
Abstract The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, gained increasing recognition as vital factors in interplay between risk This study aimed to explore effects current use high-potency methylation two independent cohorts individuals experiencing first-episode psychosis (FEP) compared control subjects....
Abstract Background The association between cannabis and psychosis is established, but the role of underlying genetics unclear. We used data from EU-GEI case-control study UK Biobank to examine independent combined effect heavy use schizophrenia polygenic risk score (PRS) on for psychosis. Methods Genome-wide summary statistics Psychiatric Genomics Consortium Genomic Psychiatry Cohort were calculate disorder (CUD) PRS 1098 participants 143600 Biobank. Both datasets had information use....
Abstract Background While cannabis use is a well-established risk factor for psychosis, little known about any association between reasons first using (RFUC) and later patterns of psychosis. Methods We used data from 11 sites the multicentre European Gene-Environment Interaction (EU-GEI) case–control study. 558 first-episode psychosis patients (FEPp) 567 population controls who had reported their RFUC. ran logistic regressions to examine whether RFUC were associated with (FEP) status. Path...
<title>Abstract</title> <bold>Background </bold>Childhood adversity is associated with various clinical dimensions in psychosis; however, how genetic vulnerability shapes the psychopathological signature yet to be clarified. <bold>Methods</bold> Using data from EU-GEI study, 376 First Episode Psychosis (FEP) cases, we evaluated interaction between polygenic risk scores for schizophrenia (SZ-PRS), bipolar disorder (BD-PRS) and major depressive (MDD-PRS), childhood on transdiagnostic of...