A5004992151- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Epilepsy research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Child Development and Digital Technology
- Multiple Sclerosis Research Studies
- Family and Disability Support Research
- Child Nutrition and Feeding Issues
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Schizophrenia research and treatment
- Genomic variations and chromosomal abnormalities
- Bipolar Disorder and Treatment
- Fetal and Pediatric Neurological Disorders
- Diet and metabolism studies
- Neonatal and fetal brain pathology
- Migraine and Headache Studies
- Genetic Neurodegenerative Diseases
- Obsessive-Compulsive Spectrum Disorders
- Ophthalmology and Eye Disorders
- COVID-19 and Mental Health
- Maternal Mental Health During Pregnancy and Postpartum
- Suicide and Self-Harm Studies
- EEG and Brain-Computer Interfaces
University of Bari Aldo Moro
2016-2025
University of Siena
2023
Weatherford College
2021
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
1999-2020
Moscow Research and Clinical Center for Neuropsychiatry
2011-2016
Fondazione Salvatore Maugeri
1999
University of Parma
1997
Paroxysmal dyskinesias are episodic movement disorders that can be inherited or sporadic in nature. The pathophysiology underlying these remains largely unknown but may involve disrupted ion homeostasis due to defects cell-surface channels nutrient transporters. In this study, we describe a family with paroxysmal exertion-induced dyskinesia (PED) over 3 generations. Their PED was accompanied by epilepsy, mild developmental delay, reduced CSF glucose levels, hemolytic anemia echinocytosis,...
Recent studies support several overlapping traits between autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD), assuming the existence of a combined phenotype. The aim our study was to evaluate common or distinctive clinical features ASD ADHD in order identify possible different phenotypes that could have value. We enrolled 181 subjects divided into four diagnostic groups: group, ASD+ADHD group (that met criteria for both ADHD), control group. Intelligent...
Learning Disorders (LD) are complex diseases that affect about 2-10% of the school-age population. We performed neuropsychological and psychopathological evaluation, in order to investigate comorbidity children with LD. Our sample consisted 448 patients from 7 16 years age a diagnosis LD, divided two subgroups: Specific (SLD), including reading, writing, mathematics disorders, Not Otherwise Specified (LD NOS). Comorbidity neuropsychopathologies was found 62.2% total sample. In LSD subgroup,...
Autism Spectrum Disorder (ASD) has historically been studied, known, and diagnosed in males. Females tend to remain unidentified, especially those with average intelligence abilities. This sex/gender difference might be partially explained by biological risk factors, but it is probably also bound methodological issues. The present study aims examine phenotypic characteristics (cognitive, emotive, socio-communicative, academic) of a group 54 females ASD matched 55 males (3–18 years), all...
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental conditions and highly heterogeneous in terms symptom profile, associated cognitive deficits, comorbidities, outcomes. Heterogeneity may also affect ability to recognize diagnose this condition. The diagnosis ADHD primarily clinical but there are increasing research efforts aiming at identifying biomarkers that can aid diagnosis.
Multiple sclerosis (MS) is a complex disease of the CNS that usually affects young adults, although 3–5% cases are diagnosed in childhood and adolescence (hence called pediatric MS, PedMS). Genetic predisposition, among other factors, seems to contribute risk onset, as adult ages, but few studies have investigated genetic 'environmentally naïve' load PedMS. The main goal this study was identify circulating markers (miRNAs), target genes (mRNAs) functional pathways associated with PedMS; we...
Since Hans Asperger's first description (Arch Psych Nervenkrankh 117:76-136, 1944), through Lorna Wing's translation and definition (Psychol Med 11:115-129, 1981), to its introduction in the fourth edition of Diagnostic Statistical Manual Mental Disorders (DSM, 1994), Asperger Syndrome has always aroused huge interest debate, until vanishing DSM fifth (2013). The debate regarded diagnostic validity differentiation from high functioning autism (HFA). present study aimed examine whether AS...
Availability of new disease-modifying therapies (DMTs) and changes therapeutic paradigms have led to a general improvement multiple sclerosis (MS) prognosis in adults. It is still unclear whether this also involves patients with pediatric-onset MS (POMS), whose early management more challenging.To evaluate the POMS over time association managing standards.Retrospective, multicenter, observational study. Data were extracted collected May 2019 from Italian Registry, digital database including...
Abstract Background Heterogeneous mental health outcomes during the COVID-19 pandemic are documented in general population. Such heterogeneity has not been systematically assessed youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of impact their predictors ASD/NDD youth, we focused on pandemic-related changes symptoms access to services. Methods Using a naturalistic observational design, parent responses Coronavirus Health...
Sleep disorders represent an important comorbidity in individuals with ADHD. While the links between ADHD and sleep disturbances have been extensively investigated, research on management of is relatively limited, albeit expanding.
The treatment of cognitive deficits is challenging in pediatric onset multiple sclerosis (POMS) and patients with attention deficit hyperactivity disorder (ADHD). We performed a pilot double-blind RCT to evaluate the efficacy home-based computerized-program for retraining two cohorts POMS ADHD patients. failing at least 2/4 tests on neuropsychological battery were randomized specific or nonspecific computerized training (ST, nST), one-hour sessions, twice/week 3 months. primary outcome was...
Objective To assess prognostic factors for a second clinical attack and first disability‐worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of multiple sclerosis (MS) patients. Methods A cohort 770 pCIS patients was followed up at least 10 years. Cox proportional hazard models Recursive Partitioning Amalgamation (RECPAM) tree‐regression were used to analyze data. Results In pCIS, female sex multifocal onset risk (hazard ratio [HR], 95% confidence interval [CI] =...
Over the last few years, new studies focused their attention on gender-related features in high-functioning autism spectrum disorder (HFA), often leading to controversial results. Another interesting aspect of these subtype patients is linked complexity clinical presentation, where besides core symptoms, other co-occurrence disorders may complicate diagnostic evaluation. Therefore, we retrospectively studied 159 HFA patients, male and female, investigating comorbidities find any gender...
Over the last decade, several studies investigated outcomes in children born very preterm. Only recently there has been an increasing interest late preterm infants (born between 34 + 0 and 36 6 weeks). This population is at high risk of morbidity mortality first years life. Other reported that they are also long-term developmental problem. Therefore, aim this study to describe neurodevelopmental emotional-behavioral outcome a sample patients.The included adolescents who had neuropsychiatric...
Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin status children and adolescents with autism spectrum disorder (ASD), but inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin (25(OH)D) concentration ASD (ASD group, n = 54) compared to affected by other neurological psychiatric disorders (non-ASD 36). All patients were admitted the Complex Operative Unit of Child Neuropsychiatry, Polyclinic Bari,...
The dopaminergic system (DS) is one of the most important neuromodulator systems involved in complex functions that are compromised both autism spectrum disorder (ASD) and attention deficit/hyperactivity (ADHD), conditions frequently occur overlap. This evidence suggests disorders might have common neurobiological pathways involving DS. Therefore, aim this study was to examine DRD1 DRD2 dopamine receptor single nucleotide polymorphisms (SNPs) as potential risk factors for ASD, ADHD, ASD/ADHD...