A5075123470- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Functional Brain Connectivity Studies
- Radiation Detection and Scintillator Technologies
- Advanced Neuroimaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Schizophrenia research and treatment
- Medical Image Segmentation Techniques
- Radiation Dose and Imaging
- Tryptophan and brain disorders
- Neurological disorders and treatments
- Photoacoustic and Ultrasonic Imaging
- Atomic and Subatomic Physics Research
- Cell Image Analysis Techniques
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Radiopharmaceutical Chemistry and Applications
- Optical Imaging and Spectroscopy Techniques
- Neurotransmitter Receptor Influence on Behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Nuclear Physics and Applications
Universidad Carlos III de Madrid
2016-2025
Hospital General Universitario Gregorio Marañón
2016-2025
Centro de Investigación Biomédica en Red de Salud Mental
2016-2025
Spanish National Centre for Cardiovascular Research
2017-2025
National University of Distance Education
2005-2025
Instituto de Salud Carlos III
2010-2024
Monash University
2023-2024
Florida College
2024
University of Florida
2024
Comunidad de Madrid
2020-2021
The effect of immunometabolism on age-associated diseases remains uncertain. In this work, we show that T cells with dysfunctional mitochondria owing to mitochondrial transcription factor A (TFAM) deficiency act as accelerators senescence. mice, these instigate multiple aging-related features, including metabolic, cognitive, physical, and cardiovascular alterations, which together result in premature death. cell metabolic failure induces the accumulation circulating cytokines, resembles...
Pregnancy is a unique neuroplastic period in adult life. This longitudinal study tracked brain cortical changes during the peripartum and explored how type of childbirth affects these changes. We collected neuroanatomic, obstetric neuropsychological data from 110 first-time mothers late pregnancy early postpartum, as well 34 nulliparous women evaluated at similar time points. During pregnancy, showed lower volume than controls across all functional networks. These differences attenuated...
Abstract In the present work, several experimental approaches were used to determine presence of glucagon‐like peptide‐1 receptor (GLP‐1R) and biological actions its ligand in human brain. situ hybridization histochemistry revealed specific labelling for GLP‐1 mRNA brain areas. addition, GLP‐1R, glucose transporter isoform (GLUT‐2) glucokinase (GK) mRNAs identified same cells, especially areas hypothalamus involved feeding behaviour. GLP‐1R gene expression gave rise a protein 56 kDa as...
We propose a new spatio-temporal elastic registration algorithm for motion reconstruction from series of images. The specific application is to estimate displacement fields two-dimensional ultrasound sequences the heart. basic idea find deformation field that effectively compensates by minimizing difference with respect reference frame. key feature our method use semi-local parametric model using splines, and reformulation task as global optimization problem. scale spline controls smoothness...
Aims The aim of this study was to determine the utility pulsed wave Doppler tissue imaging in evaluation regional left ventricular diastolic function patients with ischaemic heart disease. Methods and Results In 30 normal subjects 43 disease, performed each 16 segments myocardium. following parameters were obtained for segment: (1) early peak velocity (regional e cm.s−1); (2) late a (3) e/a ratio; (4) isovolumic relaxation time, defined as time interval from second sound onset E wave. these...
Abstract Recent functional neuroimaging studies have shown differences in brain activation between mathematically gifted adolescents and controls. The aim of this study was to investigate the relationship mathematical giftedness, intelligent quotient (IQ), microstructure white matter tracts a sample composed math‐gifted aged‐matched Math‐gifted subjects were selected through national program based on detecting enhanced visuospatial abilities creative thinking. We used diffusion tensor...
The human cerebral cortex appears to shrink during adolescence. To delineate the dynamic morphological changes involved in this process, 52 healthy male and female adolescents (11–17 years old) were neuroimaged twice using magnetic resonance imaging, approximately 2 apart. Using a novel morphometric analysis procedure combining FreeSurfer BrainVisa image software suites, we quantified global lobar change cortical thickness, outer surface area, gyrification index, average Euclidean distance...
Abstract Mapping the impact of pregnancy on human brain is essential for understanding neurobiology maternal caregiving. Recently, we found that leads to a long‐lasting reduction in cerebral gray matter volume. However, morphometric features behind volumetric reductions remain unexplored. Furthermore, similarity between these and those occurring during adolescence, another hormonally similar transitional period life, still needs be investigated. Here, used surface‐based methods analyze...
In mothers, offspring cues are associated with a powerful reinforcing value that motivates maternal care. Animal studies show this is mediated by dopamine release into the nucleus accumbens, core component of brain's reward system located in ventral striatum (VStr). The VStr also known to respond infant signals human mothers. However, it unknown whether pregnancy modifies anatomy or functionality structure, and such modifications underlie its strong reactivity cues. Therefore, we analyzed...
Deliberate and local increase of the temperature within solid tumors represents an effective therapeutic approach. Thermal therapies embrace this concept leveraging capability some species to convert absorbed energy into heat. To that end, magnetic hyperthermia (MHT) uses nanoparticles (MNPs) can effectively dissipate under alternating fields. However, MNPs fail provide real-time thermal feedback with risk unwanted overheating impeding on-the-fly adjustment parameters. Localization a tissue...
Neuroimaging researchers commonly assume that the brain of a mother is comparable to nulliparous woman. However, pregnancy leads pronounced gray matter volume reductions in mother’s brain, which have been associated with maternal attachment towards baby. Beyond two years postpartum, no study has explored whether these changes are maintained or instead return pre-pregnancy levels. The present tested detected primiparous women still six after parturition. Using data from unique, prospective...
Diastolic suction is a major determinant of early left ventricular filling in animal experiments. However, remains incompletely characterized the clinical setting.First, we validated method for measuring spatio-temporal distributions diastolic intraventricular pressure gradients and differences (DIVPDs) by digital processing color Doppler M-mode recordings. In 4 pigs, error peak DIVPD was 0.0+/-0.2 mm Hg (intraclass correlation coefficient, 0.95) compared with micromanometry. Forty patients...
Significance Noonan syndrome (NS) is a developmental disorder caused by germ-line mutations in various components of the RAS signaling pathway. The pathophysiological mechanisms underlying clinical manifestations NS patients and basis for observed phenotypic variability are poorly understood. To date, mouse models carrying Protein Tyrosine Phosphatase Non-Receptor type 11 ( Ptpn11 ), Son Sevenless homolog 1 Sos1 Raf1 loci have been described. new model described here, induced K- Ras V14I...
// Michele Cioffi 1 , Sara M. Trabulo 1, 2 Mireia Vallespinos Deepak Raj Tony Bou Kheir Meng-Lay Lin Julfa Begum Ann-Marie Baker 3 Ala Amgheib Jaimy Saif 4 Manuel Perez 5 Joaquim Soriano Desco 6, 7, 8 Maria Victoria Gomez-Gaviro Lorena Cusso Diego Megias Alexandra Aicher Christopher Heeschen Stem Cells & Cancer Group, Spanish National Research Centre (CNIO), Madrid, Spain in Ageing, Barts Institute, Queen Mary University of London, UK for Tumour Biology, School Clinical Sciences,...
Although conventional MR imaging (MRI) is the most widely used non-invasive technique for brain tumor grading, its accuracy has been reported to be relatively low. Advanced techniques, such as perfusion-weighted (PWI), diffusion-weighted (DWI), and magnetic resonance spectroscopy (MRS), could predict neoplastic histology, but their added value over MRI still open debate. We prospectively analyzed 129 patients diagnosed with primary tumors (118 gliomas) classified low-grade in 30 cases...