A5010061504- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Semiconductor Quantum Structures and Devices
- Quantum and electron transport phenomena
- Iron oxide chemistry and applications
- Nanoplatforms for cancer theranostics
- Microfluidic and Bio-sensing Technologies
- Magnetic and transport properties of perovskites and related materials
- Magnetic properties of thin films
- Gold and Silver Nanoparticles Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Physics of Superconductivity and Magnetism
- Polymer Surface Interaction Studies
- ZnO doping and properties
- Multiferroics and related materials
- Molecular Communication and Nanonetworks
- Advanced Condensed Matter Physics
- Advanced Semiconductor Detectors and Materials
- Magnetic Properties and Applications
- Magnetic Properties of Alloys
- Theoretical and Computational Physics
- Electrostatics and Colloid Interactions
- Graphene and Nanomaterials Applications
- Iron Metabolism and Disorders
- Magnetic Properties and Synthesis of Ferrites
Madrid Institute for Advanced Studies
2015-2025
Centro Nacional de Biotecnología
2015-2025
Instituto de Ciencia de Materiales de Madrid
2025
IMDEA Nanoscience
2010-2024
Consejo Superior de Investigaciones Científicas
2021
Universidad Autónoma de Madrid
2009-2017
Laboratoire National des Champs Magnétiques Intenses
1998-2010
Centre National de la Recherche Scientifique
1998-2010
GAIKER Technology Centre
2010
Polish Academy of Sciences
2010
Nowadays, magnetic hyperthermia constitutes a complementary approach to cancer treatment. The use of particles as heating mediators, proposed in the 1950s, provides novel strategy for improving tumor treatment and, consequently, patient quality life. This review reports broad overview about several aspects addressing new perspectives and progress on relevant features such ad hoc preparation nanoparticles, physical modeling heating, methods determine heat dissipation power colloids including...
The scientific community has made great efforts in advancing magnetic hyperthermia for the last two decades after going through a sizeable research lapse from its establishment. All progress various topics ranging nanoparticle synthesis to biocompatibilization and vivo testing have been seeking push forefront towards some new clinical trials. As many, they did not go at expected pace. Today, fruitful international cooperation wisdom gain careful analysis of lessons learned seminal trials...
Pancreatic ductal adenocarcinoma (PDAC) is a very challenging disease with poor prognosis. It characterized by dense desmoplastic stroma that hampers drug penetration and limits the effectiveness of conventional chemotherapy (CT). As an alternative, combination CT hyperthermia (HT) has been proposed as innovative treatment modality for PDAC. In previous works, we reported on development iron oxide magnetic nanoparticles (MNPs) that, when exposed to time-varying fields, exhibit strong HT...
Uniform iron oxide magnetic nanoparticles, with sizes in the range 9–22 nm, have been synthesized by thermal decomposition of an oleate complex 1-octadecene, controlling reaction parameters related to nucleation and growth processes. After transferring water through a ligand substitution process, nanoparticles display very good magneto-thermal properties. The relationship between these properties size distribution particles is discussed. colloidal stability dispersed common biological...
Progress in the design of nanoscale magnets for localized hyperthermia cancer therapy has been largely driven by trial-and-error approaches, instance, changing stoichiometry composition, size, and shape magnetic entities. So far, widely different often conflicting heat dissipation results have reported, particularly as a function nanoparticle concentration. Thus, achieving hyperthermia-efficient ferrofluids remains an outstanding challenge. Here we demonstrate that diverging heat-dissipation...
Magnetic nanoparticles exposed to alternating magnetic fields have shown a great potential acting as hyperthermia mediators for cancer treatment. However, dramatic and unexplained reduction of the nanoparticle heating efficiency has been evidenced when are located inside cells or tissues. Recent studies suggest enhancement clustering and/or immobilization after interaction with possible causes, although quantitative description influence biological matrices on response under AC is still...
Iron oxide nanoparticles have found an increasing number of biomedical applications as sensing or trapping platforms and therapeutic and/or diagnostic agents. Most these are based on their magnetic properties, which may vary depending the nanoparticle aggregation state concentration. In this work, we assess effect inter- intra-aggregate dipolar interactions heat dissipation power AC hysteresis loops upon concentration hydrodynamic aggregate size. We observe different effects produced by...
Deliberate and local increase of the temperature within solid tumors represents an effective therapeutic approach. Thermal therapies embrace this concept leveraging capability some species to convert absorbed energy into heat. To that end, magnetic hyperthermia (MHT) uses nanoparticles (MNPs) can effectively dissipate under alternating fields. However, MNPs fail provide real-time thermal feedback with risk unwanted overheating impeding on-the-fly adjustment parameters. Localization a tissue...
In the pursuit of controlling heat exposure mediated by magnetic nanoparticles, we provide new guidelines for tailoring relaxation processes via dipolar interactions. For this purpose, highly crystalline and monodisperse iron oxide nanocrystals whose sizes range from 7 to 22 nm were synthesized thermal decomposition organic precursors in 1-octadecene. The as-synthesized nanoparticles are soft nanomagnets, showing superparamagnetic-like behavior SAR values which progressively increase with...
Hysteresis losses in magnetic nanoparticles constitute the basis of hyperthermia for delivering a local thermal stress. Nevertheless, this therapeutic modality is only to be realised through careful appraisal best possible intrinsic and extrinsic conditions which they maximise preserve their heating capabilities. Low frequency (100 kHz) hysteresis loops accurately probe dynamical response more reliable manner than calorimetry measurements, providing conclusive quantitative data under...
Abstract Exploiting and combining different properties of nanomaterials is considered a potential route for next generation cancer therapies. Magnetic nanowires (NWs) have shown good biocompatibility high level cellular internalization. We induced cell death by the chemotherapeutic effect doxorubicin (DOX)-functionalized iron NWs with mechanical disturbance under low frequency alternating magnetic field. (3-aminopropyl)triethoxysilane (APTES) bovine serum albumin (BSA) were separately used...
Herein, by studying a stepwise phase transformation of 23 nm FeO–Fe3O4 core–shell nanocubes into Fe3O4, we identify composition at which the magnetic heating performance is not affected medium viscosity and aggregation. Structural characterizations reveal from having stoichiometric compositions Fe2+-deficient Fe3O4 phases. The resultant contain tiny compressed randomly distributed FeO subdomains as well structural defects. This causes 10-fold increase in losses nanocubes, remain...
Abstract Magnetic nanoparticles (M:NPs) are unique agents for in vivo thermal therapies due to their multimodal capacity efficient heat generation under optical and/or magnetic excitation. Nevertheless, transfer from laboratory the clinic is hampered by absence of feedback and influence that external conditions (e.g., agglomeration biological matrix interactions) have on heating efficiency. Overcoming these limitations requires, first, implementation strategies providing sensing M:NPs order...
Cellular alignment plays a pivotal role in several human tissues, including skeletal muscle, spinal cord and tendon. Various techniques have been developed to control cellular using 3D biomaterials. However, the majority of 3D-aligned scaffolds require invasive surgery for implantation. In contrast, injectable hydrogels provide non-invasive delivery method, gaining considerable attention treatment diverse conditions, osteochondral lesions, volumetric muscle loss, traumatic brain injury. We...
Breakthroughs in nanotechnology have made it possible to integrate different nanoparticles one single hybrid nanostructure (HNS), constituting multifunctional nanosized sensors, carriers, and probes with great potential the life sciences. In addition, such nanostructures could also offer therapeutic capabilities achieve a wider variety of multifunctionalities. this work, encapsulation both magnetic infrared emitting into polymeric matrix leads magnetic-fluorescent HNS multimodal imaging...
The design of magnetic nanostructures whose heating efficiency remains unaffected at the tumor site is a fundamental requirement to further advance hyperthermia in clinic. This work demonstrates that confinement nanoparticles (NPs) into sub-micrometer cavity key strategy enable certain degree nanoparticle motion and minimize aggregation effects, consequently preserving heat loss iron oxide nanocubes (IONCs) under different conditions, including intracellular environments. We fabricated...
In recent years, magnetic nanoparticles have been widely investigated due to their potential in biomedical applications. For successful vivo applications, must satisfy several requirements such as biocompatibility, invisibility the immune system, high colloidal stability biological fluids, and long blood circulation times. this study, we developed a formulation which are coated with bovine serum albumin provide enhanced fluids preserving properties. addition, carry chemotherapeutic drug,...
Iron oxide nanoparticles with engineered physical and biochemical properties are finding a rapidly increasing number of biomedical applications.However, wide variety safety concerns, especially those related to oral exposure, still needs be addressed in order reach the clinical practice.Here, we report on effects chronic exposure low dose γ-Fe 2 O 3 growing chickens.Animal observation, weight diet intake reveal no adverse signs, symptoms, or mortality.No nanoparticle accumulation was...
Combining different therapies into a single nanomaterial platform is promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such by utilizing nanowires with an iron core oxide shell as drug carriers exploiting their optical magnetic properties. The has large magnetization, which provides foundation low-power manipulation magnetomechanical treatment. enables functionalization doxorubicin through pH-sensitive linker,...
Theranosticity of nanoparticles provided by their shape, size, defects and dendron coating.
Spinel ferrite nanocubes (NCs), consisting of pure iron oxide or mixed ferrites, are largely acknowledged for their outstanding performance in magnetic hyperthermia treatment (MHT) resonance imaging (MRI) applications while particle (MPI) properties, particularly this peculiar shape different from the conventional spherical nanoparticles (NPs), relatively less investigated. In work, we report on a non-hydrolytic synthesis approach to prepare transition metal NCs. A series NCs...
A detailed study of the angular dependence magnetization reversal in polycrystalline ferromagnetic (FM)/antiferromagnetic Co/IrMn bilayers with noncollinear FM and unidirectional anisotropies shows a peculiar asymmetric magnetic behavior. The anisotropy configuration is set via field cooling (FC) procedure misaligned respect to easy direction layer. Different modes are observed for either positive or negative angles FC direction. both coercivity exchange bias also clearly displays broken...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation F. J. Teran, C. Casado, N. Mikuszeit, G. Salas, A. Bollero, M. P. Morales, Camarero, R. Miranda; Accurate determination of the specific absorption rate in superparamagnetic nanoparticles under non-adiabatic conditions. Appl. Phys. Lett. 6 August 2012; 101 (6): 062413. https://doi.org/10.1063/1.4742918 Download...