A5083064561- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Radiopharmaceutical Chemistry and Applications
- Polymer Surface Interaction Studies
- Perovskite Materials and Applications
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Nanocluster Synthesis and Applications
- Luminescence Properties of Advanced Materials
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Medical Imaging Techniques and Applications
- Electrohydrodynamics and Fluid Dynamics
- Boron Compounds in Chemistry
- Pickering emulsions and particle stabilization
- Calcium Carbonate Crystallization and Inhibition
- Laser-Ablation Synthesis of Nanoparticles
- Plasmonic and Surface Plasmon Research
- Quantum Dots Synthesis And Properties
- Lanthanide and Transition Metal Complexes
- Innovative Microfluidic and Catalytic Techniques Innovation
ITMO University
2017-2025
Russian Scientific Center of Radiology and Surgical Technologies
2020-2024
Harbin Engineering University
2024
Italian Institute of Technology
2019
Philipps University of Marburg
2015-2018
Russian Academy of Sciences
2012
Abstract Rare earth based nanostructures constitute a type of functional materials widely used and studied in the recent literature. The purpose this review is to provide general comprehensive overview current state art, with special focus on commonly employed synthesis methods functionalization strategies rare nanoparticles their different bioimaging biosensing applications. luminescent (including downconversion, upconversion permanent luminescence) magnetic properties nanoparticles, as...
Specific generation of reactive oxygen species (ROS) within tumors in situ catalyzed by nanozymes is a promising strategy for cancer therapeutics. However, it remains significant challenge to fabricate highly efficient acting the tumor microenvironment. Herein, we develop bimetallic nanozyme (Pt50Sn50) with photothermal enhancement dual enzymatic activities catalytic therapy. The structures and PtSn nanoclusters (BNCs) different Sn content are explored evaluated systematically. Experimental...
Recent reports highlighting the role of particle geometry have suggested that anisotropy can affect rate and pathway uptake by cells. Therefore, we investigate internalization cells porous calcium carbonate particles with different shapes anisotropies. We report here on a new method synthesis polyelectrolyte coated whose was controlled varying mixing speed time, pH value reaction solution, ratio interacting salts used for formation. Uptake spherical, cuboidal, ellipsoidal (with two sizes)...
Carefully designed micro- and nanocarriers can provide significant advantages over conventional macroscopic counterparts in drug delivery applications. For the successful of bioactive compounds, carriers should possess a high loading capacity, triggered release mechanisms, biocompatibility, biodegradability. Porous calcium carbonate (CaCO3) is one most promising platforms, which encompass all aforementioned requirements. Here, we study both formation particles biological applicability CaCO3....
The incorporation of bioactive compounds onto polymer fibrous scaffolds with further control drug release kinetics is essential to improve the functionality for personalized therapy and regenerative medicine. In this study, hybrid microcapsules were prepared used as carriers, which are deposited microfiber [polycaprolactone (PCL), poly(3-hydroxybutyrate) (PHB), PHB doping conductive polyaniline (PANi) 2 wt % (PHB-PANi)]. number immobilized decreased increase in their ζ-potential due...
Being the polymorphs of calcium carbonate (CaCO3), vaterite and calcite have attracted a great deal attention as promising biomaterials for drug delivery tissue engineering applications. Furthermore, they are important biogenic minerals, enabling living organisms to reach specific functions. In nature, monocrystals typically form self-assembled polycrystal micro- nanoparticles, also referred spherulites. Here, we demonstrate that alpine plants belonging Saxifraga genus can tailor light...
Abstract Drug carriers with intelligent functions are powerful therapeutic and diagnostic platforms in curing various diseases such as malignant neoplasms. These include the remote noninvasive activation of drug using physical impacts, e.g. light exposure. Combination different modalities (chemotherapy, photodynamic therapy, so forth) light-responsive enables promising synergetic effect tumour treatment. The main goal this review article is to provide state art on light-sensitive delivery...
Conventional cancer therapy methods have serious drawbacks that are related to the nonspecific action of anticancer drugs leads high toxicity on normal cells and increases risk recurrence. The therapeutic effect can be significantly enhanced when various treatment modalities implemented. Here, we demonstrate radio- photothermal (PTT) delivered through nanocarriers (gold nanorods, Au NRs) in combination with chemotherapy a melanoma results complete tumor inhibition compared single therapy....
Near-ultraviolet and visible excitable Eu- Bi-doped NPs based on rare earth vanadates (REVO4, RE = Y, Gd) have been synthesized by a facile route from appropriate precursors, europium bismuth nitrate, sodium orthovanadate, homogeneous precipitation in an ethylene glycol/water mixture at 120 °C. The can be functionalized either one-pot synthesis with polyacrylic acid (PAA) or Layer-by-Layer approach poly(allylamine hydrochloride) (PAH) PAA. In the first case, particle size also tuned...
The temperature‐dependence of the hydrodynamic diameter and colloidal stability gold‐polymer core‐shell particles with temperature‐sensitive (poly( N ‐isopropylacrylamide)) temperature‐insensitive shells (polyallylaminine hydrochloride/polystyrensulfonate, poly(isobutylene‐ alt ‐maleic anhydride)‐graft‐dodecyl) are investigated in various aqueous media. data demonstrate that for all nanoparticle agglomeration, i.e., increase effective size, presence salts or proteins dispersion media has to...
The design of magnetic nanostructures whose heating efficiency remains unaffected at the tumor site is a fundamental requirement to further advance hyperthermia in clinic. This work demonstrates that confinement nanoparticles (NPs) into sub-micrometer cavity key strategy enable certain degree nanoparticle motion and minimize aggregation effects, consequently preserving heat loss iron oxide nanocubes (IONCs) under different conditions, including intracellular environments. We fabricated...
An important area in modern malignant tumor therapy is the optimization of antitumor drugs pharmacokinetics. The use some limited clinical practice due to their high toxicity. Therefore, strategy for optimizing drug pharmacokinetics focuses on generation local concentrations these with minimal systemic and tissue-specific This can be achieved by encapsulation highly toxic (vincristine (VCR) that 20-50 times more than widely used doxorubicin) into nano- microcarriers further association...
Synthetic organic and inorganic carriers often have limitations associated with problematic targeting ability or non-optimized pharmacokinetics, and, therefore, they restricted therapeutic potential. Natural drug (e.g. mesenchymal stem cells, MSCs) are able to migrate towards the tumor site penetrate cancerous cells. These biomimetic features make MSCs an attractive delivery platform that allows achieving maximal efficiency minimal toxic side effects. A combination of exhibiting a homing...
There are many reports about the interaction of multilayer capsules with biological systems in literature. A majority them devoted to vitro study two-dimensional cell cultures. Multilayer capsule fabrication had been under intensive investigation from 1990s and 2000s by Prof. Helmuth Möhwald, his followers further developed their own research directions, focusing on implementation various fields biology medicine. The aim this future article is consistently consider most recent advances...
Halide perovskite nanomaterials are widely used in optoelectronics and photonics due to their outstanding luminescent properties, whereas strong multiphoton absorption makes them prospective for bioimaging. Nonetheless, instability of perovskites aqueous solutions is an important limitation that prevents application biology medicine. Here, we demonstrate fluorescence upconversion imaging living cells by employing CsPbBr3 nanocrystals (NCs) show improved water-resistance (at least 24 h) after...
Current applications of multifunctional nanozymes for reprogramming the redox homeostasis tumor microenvironment (TME) have been severely confronted with low catalytic activity and ambiguity active sites nanozymes, as well stress resistance from rigorous physical environment cells. Herein, Sm/Co-doped mesoporous silica 3PO-loaded (denoted mSC-3PO) are rationally constructed simultaneously inhibiting energy production by adenosine triphosphate (ATP) inhibitor 3PO TME multiactivities...