A5071615460- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Image and Signal Denoising Methods
- Cardiovascular Function and Risk Factors
- Microfluidic and Capillary Electrophoresis Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Biosensors and Analytical Detection
- Simulation-Based Education in Healthcare
- Advanced MRI Techniques and Applications
- Medical Image Segmentation Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- COVID-19 epidemiological studies
- Cardiac electrophysiology and arrhythmias
- Vaccine Coverage and Hesitancy
- Parasites and Host Interactions
- Cardiovascular Health and Disease Prevention
- SARS-CoV-2 and COVID-19 Research
- Disaster Response and Management
University Hospital of Basel
2015-2024
European Foundation for Clinical Nanomedicine
2013-2023
University of Basel
2010-2022
Kantonsspital Aarau
2022
Andover Eye Associates
2019-2021
Hospital Base
2021
Novartis Foundation
2016-2020
European Society of Clinical Microbiology and Infectious Diseases
2015-2019
Swiss Tropical and Public Health Institute
2019
University of Bern
2012
We demonstrate continuous label-free detection of two cardiac biomarker proteins (creatin kinase and myoglobin) using an array microfabricated cantilevers functionalized with covalently anchored anti-creatin anti-myoglobin antibodies. This method allows to be detected via measurement surface stress generated by antigen–antibody molecular recognition. Reference are used eliminate thermal drifts, undesired chemical reactions turbulences from injections liquids calculating differential...
Autonomous capillary systems (CSs), where liquids are displaced by means of capillarity, efficient, fast and convenient platforms for many bioanalytical applications. The proper functioning these microfluidic devices requires displacing accurate volumes with precise flow rates. In this work, we show how to design pumps controlling the properties CSs. comprise microstructures various shapes dimensions from 15-250 microm, which positioned in encode a desired pressure. designed have small...
Background: Few studies describe recent changes in the incidence, treatment, and outcomes of cardiogenic shock. Objective: To examine temporal trends therapeutic management, mortality rates patients with acute coronary syndrome (ACS) shock, to assess associations management death shock developing during hospitalization. Design: Analysis registry data collected among admitted hospitals between 1997 2006. Setting: 70 106 cardiac care Switzerland. Patients: 23696 adults ACS enrolled AMIS (Acute...
The vasoconstrictor peptide endothelin-1 (ET-1) is important for increased vascular tone in patients with chronic heart failure, but the effects of endothelin-receptor blockade addition to conventional triple therapy are unknown.Thirty-six men (mean age+/-SD, 55+/-8 years) symptomatic failure (NYHA class III; left ventricular ejection fraction, 22.4+/-4.5%) despite treatment diuretics, digoxin, and ACE inhibitors received, a double-blind randomized fashion, either additional oral bosentan...
We propose a new spatio-temporal elastic registration algorithm for motion reconstruction from series of images. The specific application is to estimate displacement fields two-dimensional ultrasound sequences the heart. basic idea find deformation field that effectively compensates by minimizing difference with respect reference frame. key feature our method use semi-local parametric model using splines, and reformulation task as global optimization problem. scale spline controls smoothness...
To develop an intelligent sensor−effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and pH-sensitive enzyme acid phosphatase, resulting in switchable substrate processing at pH 4−6.5. Ideal concentrations for reaction determined experimentally. In future, reactor might be used self-regulating targeted diagnostic therapeutic applications...
Mechanistic insights from 3D echocardiography (echo) can guide therapy. In particular, ischemic mitral regurgitation (MR) is difficult to repair, often persisting despite annular reduction. We hypothesized that (1) in a chronic infarct model of progressive MR, parallels changes the geometry leaflet attachments, causing increased tethering and restricting closure; therefore, (2) MR be reduced by restoring toward normal, using new ventricular remodeling approach based on echo findings.We...
The influence of teaching leadership on the performance rescuers remains unknown. aim this study was to compare instruction with a general technical in high-fidelity simulated cardiopulmonary resuscitation scenario.Prospective, randomized, controlled superiority trial.Simulator Center University Hospital Basel Switzerland.Two-hundred thirty-seven volunteer medical students teams three.During baseline visit, participated video-taped witnessed cardiac arrest. Participants were thereafter...
Abstract Introduction The Glasgow Coma Scale (GCS) is the most widely used scoring system for comatose patients in intensive care. Limitations of GCS include impossibility to assess verbal score intubated or aphasic patients, and an inconsistent inter-rater reliability. FOUR (Full Outline UnResponsiveness) score, a new coma scale not reliant on response, was recently proposed. aim present study compare reliability among unselected general critical A further neurologists with that care unit...
Abstract Background Cardiac arrests are handled by teams rather than individual health-care workers. Recent investigations demonstrate that adherence to CPR guidelines can be less optimal, deviations from treatment algorithms associated with lower survival rates, and deficits in performance shortcomings the process of team-building. The aim this study was explore quantify effects ad-hoc team-building on among two types physicians play an important role as first responders during CPR: general...
The quantitative assessment of cardiac motion is a fundamental concept to evaluate ventricular malfunction. We present new optical-flow-based method for estimating heart from two-dimensional echocardiographic sequences. To account typical motions, such as contraction/expansion and shear, we analyze the images locally by using local-affine model velocity in space linear time. regional parameters are estimated least-squares sense inside sliding spatiotemporal B-spline window. Robustness...