A5078093706- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Cosmology and Gravitation Theories
- Neutrino Physics Research
- Computational Physics and Python Applications
- Black Holes and Theoretical Physics
- Particle Accelerators and Free-Electron Lasers
- Distributed and Parallel Computing Systems
- Medical Imaging Techniques and Applications
- Astrophysics and Cosmic Phenomena
- COVID-19 Clinical Research Studies
- CRISPR and Genetic Engineering
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- advanced mathematical theories
- Parkinson's Disease Mechanisms and Treatments
- Muon and positron interactions and applications
- RNA modifications and cancer
- Food Science and Nutritional Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Chromosomal and Genetic Variations
Jaipur National University
2017-2025
WinnMed
2021-2024
German Center for Neurodegenerative Diseases
2017-2024
Mayo Clinic
2021-2024
Indian Institute of Technology Delhi
2024
Medanta The Medicity
2023
David Tvildiani Medical University
2023
B.J. Medical College
2023
Mayo Clinic in Arizona
2022
Nemours Children's Clinic
2022
We report a measurement of the branching fraction ratios R(D(*)) Bbar -> D(*) tau- nubar_tau relative to D()* l- nubar_l (where l = e or mu) using full Belle data sample 772 x 10^6 BBbar pairs collected at Y(4S) resonance with detector KEKB asymmetric-energy e+e- collider. The measured values are R(D)= 0.375 +- 0.064(stat.) 0.026(syst.) and R(D*) 0.293 0.038(stat.) 0.015(syst.). analysis uses hadronic reconstruction tag-side B meson purely leptonic tau decays. results consistent earlier...
We report the first measurement of $\ensuremath{\tau}$ lepton polarization ${P}_{\ensuremath{\tau}}({D}^{*})$ in decay $\overline{B}\ensuremath{\rightarrow}{D}^{*}{\ensuremath{\tau}}^{\ensuremath{-}}{\overline{\ensuremath{\nu}}}_{\ensuremath{\tau}}$ as well a new ratio branching fractions...
We report a measurement of the ratio ${\cal R}(D^*) = {\cal B}(\bar{B}^0 \rightarrow D^{*+} \tau^- \bar{\nu}_{\tau})/{\cal \ell^- \bar{\nu}_{\ell})$, where $\ell$ denotes an electron or muon. The results are based on data sample containing $772\times10^6$ $B\bar{B}$ pairs recorded at $\Upsilon(4S)$ resonance with Belle detector KEKB $e^+ e^-$ collider. select $B^0 \bar{B}^0$ by reconstructing both $B$ mesons in semileptonic decays to $D^{*\mp} \ell^{\pm}$. measure R}(D^*)= 0.302 \pm...
We present a measurement of angular observables and test lepton flavor universality in the $B\ensuremath{\rightarrow}{K}^{*}{\ensuremath{\ell}}^{+}{\ensuremath{\ell}}^{\ensuremath{-}}$ decay, where $\ensuremath{\ell}$ is either $e$ or $\ensuremath{\mu}$. The analysis performed on data sample corresponding to an integrated luminosity $711\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ containing $772\ifmmode\times\else\texttimes\fi{}1{0}^{6}$ $B\overline{B}$ pairs, collected at...
To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-associated receptors factors (SCARFs) using single-cell transcriptomics across various healthy tissues. SCARFs include cellular both facilitating restricting viral entry. Intestinal goblet cells, enterocytes, kidney proximal tubule cells appear highly permissive to SARS-CoV-2, consistent with clinical data. Our analysis also predicts non-canonical entry paths for lung brain infections. Spermatogonial...
With the full data sample of $772 \times 10^6$ $B{\bar B}$ pairs recorded by Belle detector at KEKB electron-positron collider, decay $\bar{B} \rightarrow D^* \tau^- \bar{\nu}_\tau$ is studied with hadronic $\tau$ decays $\tau^- \pi^- \nu_\tau$ and \rho^- \nu_\tau$. The polarization $P_\tau(D^*)$ in two-body measured, as well ratio branching fractions $R(D^{*}) = \mathcal{B}(\bar {B} \bar{\nu}_\tau) / \mathcal{B}(\bar{B} \ell^- \bar{\nu}_\ell)$, where $\ell^-$ denotes an electron or a muon....
Abstract A fundamental problem in biomedical research is the low number of observations available, mostly due to a lack available biosamples, prohibitive costs, or ethical reasons. Augmenting few real with generated silico samples could lead more robust analysis results and higher reproducibility rate. Here, we propose use conditional single-cell generative adversarial neural networks (cscGAN) for realistic generation RNA-seq data. cscGAN learns non-linear gene–gene dependencies from...
We present the results of an amplitude analysis anti-B0 -> J/psi K- pi+ decays. A new charged charmoniumlike state Zc(4200)+ decaying to is observed with a significance 6.2 sigma. The mass and width are 4196 +31-29 +17-13 MeV/c^2 370 +70-70 +70-132 MeV, respectively; preferred assignment quantum numbers J^P = 1^+. In addition, we find evidence for Zc(4430)+ pi+. based on 711 fb^-1 data sample collected by Belle detector at asymmetric-energy e+ e- collider KEKB.
We present the results of a search for rare decays $B\to h\nu\overline{\nu}$, where $h$ stands $K^+,\:K^0_{\mathrm{S}},\:K^{\ast +},\:K^{\ast 0},\:\pi^+,\:\pi^0,\:\rho^+$ and $\rho^{0}$. The are obtained with $772\times10^{6}$ $B\overline{B}$ pairs collected Belle detector at KEKB $e^+ e^-$ collider. reconstruct one $B$ meson in semileptonic decay require single but nothing else on signal side. observe no significant set upper limits branching fractions. K^0_{\mathrm{S}}\nu\overline{\nu}$,...
We present a determination of the magnitude Cabibbo-Kobayashi-Maskawa matrix element $|V_{cb}|$ using decay $B\to D\ell\nu_\ell$ ($\ell=e,\mu$) based on 711 fb$^{-1}$ $e^+e^-\to \Upsilon(4S)$ data recorded by Belle detector and containing $772 \times 10^6$ $B\bar{B}$ pairs. One $B$ meson in event is fully reconstructed hadronic mode while other, signal side, partially from charged lepton either $D^+$ or $D^0$ total 23 modes. The isospin-averaged branching fraction found to be...
We report measurement of the cross section $e^+e^-\to \pi^+\pi^-\psi(2S)$ between 4.0 and $5.5 {\rm GeV}$, based on an analysis initial state radiation events in a $980 \rm fb^{-1}$ data sample recorded with Belle detector. The properties $Y(4360)$ $Y(4660)$ states are determined. Fitting mass spectrum $\pi^+\pi^-\psi(2S)$ two coherent Breit-Wigner functions, we find solutions identical width but different couplings to electron-positron pairs: $M_{Y(4360)} = (4347\pm 6\pm 3) MeV}/c^2$,...
We present a measurement of angular observables and test lepton flavor universality in the $B\to K^\ast \ell^+\ell^-$ decay, where $\ell$ is either $e$ or $μ$. The analysis performed on data sample corresponding to an integrated luminosity $711~\mathrm{fb}^{-1}$ containing $772\times 10^{6}$ $B\bar B$ pairs, collected at $Υ(4S)$ resonance with Belle detector asymmetric-energy $e^+e^-$ collider KEKB. result consistent Standard Model (SM) expectations, largest discrepancy from SM prediction...
We present a measurement of angular observables, $P_4'$, $P_5'$, $P_6'$, $P_8'$, in the decay $B^0 \to K^\ast(892)^0 \ell^+ \ell^-$, where $\ell^+\ell^-$ is either $e^+e^-$ or $\mu^+\mu^-$. The analysis performed on data sample corresponding to an integrated luminosity $711~\mathrm{fb}^{-1}$ containing $772\times 10^{6}$ $B\bar B$ pairs, collected at $\Upsilon(4S)$ resonance with Belle detector asymmetric-energy collider KEKB. Four $P_{4,5,6,8}'$ are extracted five bins invariant mass...
Abstract Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with novel line reporter mice that cognitive challenge induces local/endogenous hypoxia hippocampal pyramidal neurons, hence enhancing expression and receptor (EPOR). High-dose administration, amplifying auto/paracrine EPO/EPOR...
We present a new measurement of the Cabibbo-Kobayashi-Maskawa matrix element $|{V}_{cb}|$ from ${B}^{0}\ensuremath{\rightarrow}{D}^{*\ensuremath{-}}{\ensuremath{\ell}}^{+}{\ensuremath{\nu}}_{\ensuremath{\ell}}$ decays, reconstructed with full Belle data set $711\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ integrated luminosity. Two form factor parametrizations, originally conceived by Caprini-Lellouch-Neubert (CLN) and Boyd, Grinstein Lebed (BGL) groups, are used to extract product...
In patients with Charcot-Marie-Tooth disease 1A (CMT1A), peripheral nerves display aberrant myelination during postnatal development, followed by slowly progressive demyelination and axonal loss adult life. Here, we show that myelinating Schwann cells in a rat model of CMT1A exhibit developmental defect includes reduced transcription genes required for myelin lipid biosynthesis. Consequently, incorporation into is reduced, leading to an overall distorted stoichiometry proteins lipids...
Using the entire Belle data sample of 980 ${\rm fb}^{-1}$ $e^+e^-$ collisions, we present results a study excited $\Omega_c$ charmed baryons in decay mode $\Xi_c^+K^-$. We show confirmation four five narrow states reported by LHCb Collaboration: $\Omega_c(3000)$ , $\Omega_c(3050)$, $\Omega_c(3066)$, and $\Omega_c(3090)$.
Higher educational attainment (EA) is negatively associated with schizophrenia (SZ). However, recent studies found a positive genetic correlation between EA and SZ. We investigate possible causes of this counterintuitive finding using genome-wide association study results for SZ (N = 443,581) replication cohort (1169 controls; 1067 cases) deeply phenotyped patients. find strong dependence that cannot be explained by chance, linkage disequilibrium, or assortative mating. Instead, several...
Abstract Aggregates of medin amyloid (a fragment the protein MFG-E8, also known as lactadherin) are found in vasculature almost all humans over 50 years age 1,2 , making it most common currently known. We recently reported that aggregates blood vessels ageing wild-type mice, causing cerebrovascular dysfunction 3 . Here we demonstrate amyloid-β precursor (APP) transgenic mice and patients with Alzheimer’s disease co-localizes vascular deposits, deficiency reduces deposition by half. Moreover,...
The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an international collaboration producing fundamental resources disease (PD). FOUNDIN-PD generated a multi-layered molecular dataset in cohort of induced pluripotent stem cell (iPSC) lines differentiated to dopaminergic (DA) neurons, major affected type PD. were derived from the Parkinson's Progression Markers study, which included participants with PD carrying monogenic variants, variants intermediate effects, and...
We perform a full amplitude analysis of the process ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}J/\ensuremath{\psi}D\overline{D}$, where $D$ refers to either ${D}^{0}$ or ${D}^{+}$. A new charmoniumlike state ${X}^{*}(3860)$ that decays $D\overline{D}$ is observed with significance $6.5\ensuremath{\sigma}$. Its mass $({3862}_{\ensuremath{-}32}^{+26}{\text{ }}_{\ensuremath{-}13}^{+40})\text{ }\text{ }\mathrm{MeV}/{c}^{2}$, and its width $({201}_{\ensuremath{-}67}^{+154}{\text{...
Received 25 April 2018DOI:https://doi.org/10.1103/PhysRevD.97.099902© 2018 American Physical SocietyPhysics Subject Headings (PhySH)Research AreasFlavor changing neutral currentsParticle decaysParticle interactionsParticles & Fields
Objective To provide insights into the nature, risk factors, impact and existing measures for reporting preventing violence in healthcare system. The under-reporting of against workers (HCWs) globally highlights need increased public awareness education. Methods Violence Study Healthcare Workers Systems study used a survey questionnaire created using Research Electronic Data Capture (REDCap) forms distributed from 6 June to 9 August 2022. Logistic regression analysis evaluated predictors,...