A5003642501- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Anesthesia and Neurotoxicity Research
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Axon Guidance and Neuronal Signaling
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Apelin-related biomedical research
- Cell Image Analysis Techniques
- Cannabis and Cannabinoid Research
- Attention Deficit Hyperactivity Disorder
- Neurobiology and Insect Physiology Research
- Neural and Behavioral Psychology Studies
- Adipose Tissue and Metabolism
- Proteoglycans and glycosaminoglycans research
- Nicotinic Acetylcholine Receptors Study
- Wnt/β-catenin signaling in development and cancer
Universitat Jaume I
2024
Universitat de València
2012-2023
INCLIVA Health Research Institute
2011-2021
Gobierno de Aragón
2020-2021
University of Helsinki
2013-2020
Centro de Investigación Biomédica en Red de Salud Mental
2020
Hospital Clínico Universitario de Valencia
2012
Novel hypotheses suggest that antidepressants, such as the selective serotonin reuptake inhibitor fluoxetine, induce neuronal structural plasticity, resembling of juvenile brain, although underlying mechanisms this reopening critical periods still remain unclear. However, recent studies inhibitory networks play an important role in plasticity induced by fluoxetine. For reason we have analysed effects a chronic fluoxetine treatment hippocampus and medial prefrontal cortex (mPFC) transgenic...
Parvalbumin-expressing (PV+) interneurons play a key role in the maturation and synchronization of cortical circuitry alterations these inhibitory neurons, especially medial prefrontal cortex (mPFC), have been found different psychiatric disorders. The formation perineuronal nets (PNNs) around many at end critical periods reduces their plasticity sets connectivity. Consequently, presence PNNs must an important impact on synaptic input physiology PV+ cells. In present study, we that adult...
Abstract Background Social cognition has been associated with functional outcome in patients first episode psychosis (FEP). also neurocognition and cognitive reserve. Although reserve, neurocognitive functioning, social cognition, are related, the direction of their associations is not clear. Therefore, main aim this study was to analyze influence as a mediator between reserve domains on functioning FEP both at baseline 2 years. Methods The sample composed 282 followed up for To whether...
New neurons in the adult brain transiently express molecules related to neuronal development, such as polysialylated form of neural cell adhesion molecule, or doublecortin (DCX). These are also expressed by a population rat paleocortex layer II, whose origin, phenotype, and function not clearly understood. We have classified most these cells new type termed tangled cell. Some with morphology semilunar–pyramidal transitional were found among this population, well some scarce resembling...
Principal neurons in the adult cerebral cortex undergo synaptic, dendritic, and spine remodeling response to different stimuli, several reports have demonstrated that polysialylated form of neural cell adhesion molecule (PSA-NCAM) participates these plastic processes. However, there is only limited information on expression this interneurons its role structural plasticity cells. We found PSA-NCAM expressed mature widely distributed all extension excluded most principal Although generally...
A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset patients, but the neurobiological basis these observations remains obscure. We show that single produces antidepressant-like behavioural effects learned helplessness paradigm and regulates molecular events implicated mechanism action rapid-acting antidepressant ketamine: activation brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation mammalian target...
Abstract Background Antidepressants promote neuronal structural plasticity in young-adult rodents, but little is known of their effects on older animals. The polysialylated form the neural cell adhesion molecule (PSA-NCAM) may mediate these changes through its anti-adhesive properties. PSA-NCAM expressed immature neurons and a subpopulation mature interneurons expression modulated by antidepressants telencephalon rodents. Results We have analyzed 14 days fluoxetine treatment density puncta...
Excitatory neurons undergo dendritic spine remodeling in response to different stimuli. However, there is scarce information about this type of plasticity interneurons. The polysialylated form the neural cell adhesion molecule (PSA-NCAM) a good candidate mediate as it participates neuronal and expressed by some mature cortical interneurons, which have reduced arborization, density, synaptic input. To study connectivity spines interneurons influence PSA-NCAM on their dynamics, we analyzed...
The quantification of the expression different molecules is a key question in both basic and applied sciences. While protein through molecular techniques leads to loss spatial information resolution, immunohistochemistry usually associated with time-consuming image analysis human bias. In addition, scarce automatic software often proprietary expensive relies on fixed threshold binarization. Here we describe share set macros ready for automated fluorescence large batches tissue samples using...
Chronic stress has an important impact on the adult brain. However, most of knowledge its effects is focused principal neurons and less inhibitory neurons. Consequently, recent reports have begun to describe stress-induced alterations in structure, connectivity neurochemistry interneurons. Some these changes appear be mediated by certain molecules particularly associated interneurons, such as polysialylated form neural cell adhesion molecule (PSA-NCAM) components perineuronal nets (PNN),...
Alterations in the structure and physiology of interneurons prefrontal cortex (PFC) are important factors etiopathology different psychiatric disorders. Among interneuronal subpopulations, parvalbumin (PV) expressing cells appear to be specially affected. Interestingly, during development adulthood connectivity these is regulated by presence perineuronal nets (PNNs), specialized regions extracellular matrix, which frequently surrounding PV neurons. Previous reports have found anomalies...
This manuscript is dedicated to the memory of Bruce S. McEwen, commemorate impact he had on how we understand stress and neuronal plasticity, profound influence exerted our scientific careers. The focus this review stressors inhibitory circuits, particularly those limbic system, but also consider other regions affected by these adverse experiences. We revise effects acute chronic during different stages development lifespan, taking into account sex animals. first physiology neurons...
Abstract Critical period-like plasticity (iPlasticity) can be reinstated in the adult brain by several interventions, including drugs and optogenetic modifications. We have demonstrated that a combination of iPlasticity with optimal training improves behaviors related to neuropsychiatric disorders. In this context, activation TrkB, receptor for BDNF, Parvalbumin-positive (PV + ) interneurons has pivotal role cortical network changes. However, it is unknown if TrkB PV important other...
N-methyl-D-aspartate receptors (NMDARs) are present in both pyramidal neurons and interneurons of the hippocampus. These play an important role adult structural plasticity excitatory neurons, but their impact on remodeling is unknown. Among hippocampal interneurons, somatostatin-expressing cells located stratum oriens special interest because functional importance characteristics: they display dendritic spines, which change density response to different stimuli. In order understand NMDARs...