A5021279453- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Advanced Chemical Sensor Technologies
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Photochromic and Fluorescence Chemistry
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
Yale University
2018-2025
Universitat de València
2010-2015
Parkinson's disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathologic changes in the pathway of transgenic (Tg) mice both sexes expressing human A30P mutant α-synuclein (α-syn; α-syn-Tg mice) at 6–7 and 12–14 months age, representing early late-stages motor progression, respectively. α-Syn-Tg late stages exhibited behavioral deficits, which correlated with severe α-syn pathology projection...
Excitatory neurons undergo dendritic spine remodeling in response to different stimuli. However, there is scarce information about this type of plasticity interneurons. The polysialylated form the neural cell adhesion molecule (PSA-NCAM) a good candidate mediate as it participates neuronal and expressed by some mature cortical interneurons, which have reduced arborization, density, synaptic input. To study connectivity spines interneurons influence PSA-NCAM on their dynamics, we analyzed...
The formation of the olfactory nerve and bulb (OB) glomeruli begins embryonically in mice. However, development system continues throughout life with addition new sensory neurons (OSNs) epithelium (OE). Much attention has been given to perinatal innervation OB by OSN axons, but young adult process maturation axon targeting remains controversial. To address this gap understanding, we used BrdU label late-born OSNs mice at postnatal day 25 (P25-born OSNs) timed their molecular following basal...
The olfactory nerve constitutes the first cranial pair. Compared with other nerves, it depicts some atypical features. First, does not form a unique bundle. axons join and several small bundles or fascicles: fila olfactoria. These fascicles leave nasal cavity, pass through lamina cribrosa of ethmoid bone enter brain. whole these is what known as nerve. Second, sensory neurons, whose integrate nerve, connect cavity brain without any relay. Third, composed by unmyelinated axons. Fourth,...
ABSTRACT In the olfactory bulb (OB), odorant receptor‐specific input converges into glomeruli. Subsequently, coding of odor information is fine‐tuned by local synaptic circuits within glomeruli and deeper external plexiform layer (EPL) in OB. Deciphering organization inhibitory granule cells (GCs) EPL relative to secondary dendrites projection neurons pivotal for understanding processing. We conducted a detailed investigation GCs, focusing on timing neurogenesis, laminar distribution,...
New neurons are continually generated in the subependymal layer of lateral ventricles and subgranular zone dentate gyrus during adulthood. In subventricular zone, neuroblasts migrate a long distance to olfactory bulb where they differentiate into granule or periglomerular interneurons. hippocampus, short from cell become neurons. addition short-distance inputs, bulbar interneurons receive long-distance centrifugal afferents olfactory-recipient structures. Similarly, cells differential inputs...
Microglia invade the neuroblast migratory corridor of rostral stream (RMS) early in development. The postnatal RMS does not yet have dense astrocyte and vascular scaffold that helps propel forward migrating neuroblasts, which led us to consider whether microglia help regulate conditions permissive migration RMS. GFP-labeled CX3CR-1GFP/+ mice assemble primarily along outer borders during first week, where they exhibit predominantly an ameboid morphology associate with neuroblasts. ablation...
ABSTRACT In the olfactory bulb odorant receptor specific input converges into glomeruli. Deep to glomeruli coding of odor information is tuned by local synaptic circuits. Deciphering dendritic organization granule cells relative secondary dendrites projection neurons a pivotal for understanding processing. We carried out detailed interrogation including timing neurogenesis, laminar distribution and synaptogenesis between neurons. brief, develop following outside in maturation pattern from...
The olfactory bulb (OB) of mammals receives cholinergic afferents from the horizontal limb diagonal band Broca (HDB). At present, synaptic connectivity axons on circuits OB has only been investigated in rat. In this report, we analyze cynomolgus monkey (Macaca fascicularis). Our aim is to investigate whether innervation bulbar phylogenetically conserved between macrosmatic and microsmatic mammals. results demonstrate that form contacts interneurons. glomerular layer, their main targets are...
ABSTRACT Microglia invade the neuroblast migratory corridor of rostral stream (RMS) early in development. This work examines how microglia maintain homeostatic conditions permissive to migration RMS during postnatal period. GFP labeled CX3CR-1 GFP/+ mice assemble primarily along outer borders first week, where they exhibit predominantly an ameboid morphology and associate with migrating neuroblasts. ablation for 3 days postnatally does not impact density pulse BrdU+ neuroblasts nor distance...
Abstract Parkinson’s Disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathological changes in the pathway of transgenic (Tg) mice expressing human A30P mutant α-synuclein (α-syn) (α-syn-Tg mice) at 6-7 and 12-14 months age, representing early late-stages motor progression, respectively. α-Syn-Tg late stages exhibited behavioral deficits, which correlated with severe α-syn pathology projection...