A5030814868- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Hungarian Social, Economic and Educational Studies
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Hypothalamic control of reproductive hormones
- Herpesvirus Infections and Treatments
- Global Energy Security and Policy
- Oral and Maxillofacial Pathology
- Neural dynamics and brain function
- Machine Learning in Healthcare
- Functional Brain Connectivity Studies
- Diagnosis and treatment of tuberculosis
- Risk Perception and Management
- Artificial Intelligence in Healthcare and Education
- Growth Hormone and Insulin-like Growth Factors
- Cytomegalovirus and herpesvirus research
- linguistics and terminology studies
- Platelet Disorders and Treatments
- Language, Metaphor, and Cognition
HUN-REN Institute of Experimental Medicine
2011-2024
University of Szeged
2018-2024
Neuroscience Institute
2024
Hungarian Research Network
2024
Semmelweis University
2024
Czech Academy of Sciences, Institute of Experimental Medicine
2023
BlackRock (United States)
2022
Imperial College London
2022
Hungarian Academy of Sciences
2005-2020
University of California, San Diego
2013-2020
Disturbed social relations during childhood (e.g., neglect) often lead to aggression-related psychopathologies in adulthood. Social isolation also increased aggressiveness laboratory animals. Here the authors show rats, that from weaning not only increases level of aggressiveness, but results abnormal attack patterns and deficits communication. In socially deprived share attacks aimed at vulnerable body parts opponents (head, throat, belly) dramatically attack/threat ratio was shifted toward...
An important question in behavioral neurobiology is how particular neuron populations and pathways mediate the overall roles of brain structures. Here we investigated this issue by studying medial prefrontal cortex (mPFC), an established locus inhibitory control aggression. We male rats that dominantly distinct mPFC project to produce dense fiber networks with glutamate release sites mediobasal hypothalamus (MBH) lateral (LH; i.e., two executory centers species-specific violent bites,...
Molar MOD (mesial-occlusal-distal) cavity preparation weakens relative cuspal stiffness by up to 63%, often resulting in fracture. This investigation inspects fracture resistance of cavities restored using direct composite restoration.120 extracted, intact mandibular molars were selected. with different depth/wall thickness prepared 9 groups (n = 12): A: 3 mm/3.5 mm, B: mm/2.5 C: mm/1.5 D: 5 E: F: G: 7 H: I: mm. Specimens mm deep received root canal treatment. The teeth dental composite....
Abstract Callous‐unemotional violence associated with antisocial personality disorder is often called ‘predatory’ because it involves restricted intention signaling and low emotional/physiological arousal, including decreased glucocorticoid production. This epithet may be a mere metaphor, but also cover structural similarity at the level of hypothalamus where control affective predatory aggression diverges. We investigated this hypothesis in laboratory model production chronically limited by...
As previously shown, rats isolated from weaning develop abnormal social and aggressive behavior characterized by biting attacks targeting vulnerable body parts of opponents, reduced attack signaling, increased defensive despite counts. Here we studied whether this form violent aggression could be reversed resocialization in adulthood. During the first weak resocialization, isolation-reared showed multiple deficits including defensiveness decreased huddling during sleep. Deficits were...
Excessive fear learning and generalized, extinction-resistant memories are core symptoms of anxiety trauma-related disorders. Despite significant evidence from clinical studies reporting hyperactivity the bed nucleus stria terminalis (BNST) under these conditions, role BNST in expression is still not clarified. Here, we tested how modulates male mice using a chemogenetic approach. Activation GABAergic neurons during conditioning or memory consolidation resulted enhanced cue-related recall....
Background: In recent months, ChatGPT, a general artificial intelligence, has become cultural phenomenon in the scientific community and audience as well. A widely increasing number of papers discussed ChatGPT powerful tool writing programming but its use medical is largely overlooked. Here we show that can be used valuable innovative augmentation modern medicine, especially diagnostic tool. Methods: We synthetic data generated by neurological experts to represent descriptive anamneses...
Anxiety and trauma-related disorders are characterized by significant alterations in threat detection, resulting inadequate fear responses evoked weak threats or safety stimuli. Recent research pointed out the important role of bed nucleus stria terminalis (BNST) anticipation modulation under ambiguous threats, hence, exaggerated may be traced back to altered BNST function. To test this hypothesis, we chemogenetically inhibited specific neuronal populations (corticotropin-releasing hormone -...
The human cytomegalovirus U,SO protease was expressed in Escherichia coli and purified by metalchelate chromatography using a histidine tag engineered at the amino terminus.Cleavage of 30-kDa an internal site, resulted recovery 16-plus 14-kDa two-chain protease.The amino-terminal 16-kDa chain carboxyl-terminal remained associated as active enzyme that modified specifically Seri3' on [3H]diisopropyl fluorophosphate.Disruption cleavage site mutation from VENA to AEAIA facilitated one-chain...