A5003243052- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neonatal and fetal brain pathology
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Erythropoietin and Anemia Treatment
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Anesthesia and Neurotoxicity Research
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Blood transfusion and management
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Attention Deficit Hyperactivity Disorder
- interferon and immune responses
- Mental Health Research Topics
- Zebrafish Biomedical Research Applications
- Functional Brain Connectivity Studies
Leibniz Institute for Resilience Research
2020-2024
Loyola University Chicago
2022
University Medical Center of the Johannes Gutenberg University Mainz
2015-2021
Johannes Gutenberg University Mainz
2015-2021
École Polytechnique Fédérale de Lausanne
2011-2018
Focus (Germany)
2015
University Medical Center Utrecht
2007-2012
Wilhelmina Children's Hospital
2009-2012
Utrecht University
1977-2011
Significance Within a dominance hierarchy, low social status strongly reduces individual well-being. In socially living species, rank in hierarchy is determined through competitive encounters. Despite the numerous health consequences, ability of personality traits to predispose individuals particular remains largely unclear. Our work identifies trait anxiety as predisposing factor subordinate rank. We demonstrate that mitochondrial function nucleus accumbens, brain region relevant for...
Abstract Chronic stress is a risk factor for the development of psychopathologies characterized by cognitive dysfunction and deregulated social behaviours. Emerging evidence suggests role cell adhesion molecules, including nectin-3, in mechanisms that underlie behavioural effects stress. We tested hypothesis proteolytic processing nectins matrix metalloproteinases (MMPs), an enzyme family degrades numerous substrates, involved hippocampal induced chronic restraint A reduction nectin-3...
Benzodiazepines can ameliorate social disturbances and increase competition, particularly in high-anxious individuals. However, the neural circuits mechanisms underlying benzodiazepines' effects competition are not understood. Converging evidence points to mesolimbic system as a potential site of action for at least some benzodiazepine-mediated effects. Furthermore, mitochondrial function nucleus accumbens (NAc) has been causally implicated link between anxiety competitiveness. Here, we show...
To investigate whether inhibition of mitochondrial p53 association using pifithrin-μ (PFT-μ) represents a potential novel neuroprotective strategy to combat perinatal hypoxic-ischemic (HI) brain damage.Seven-day-old rats were subjected unilateral carotid artery occlusion and hypoxia followed by intraperitoneal treatment with PFT-μ, an inhibitor or PFT-α transcriptional activity. Cerebral damage, sensorimotor cognitive function, apoptotic pathways (cytosolic cytochrome c, Smac/DIABLO, active...
Stringent glucose demands render the brain susceptible to disturbances in supply of this main source energy, and chronic stress may constitute such a disruption. However, whether stress-associated cognitive impairments arise from disturbed regulation remains unclear. Here we show that social defeat (CSD) adult male mice induces hyperglycemia directly affects spatial memory performance. Stressed developed impaired metabolism peripherally as well (demonstrated by PET induced metabolic...