A5084163212- Hearing Impairment and Communication
- Neuropeptides and Animal Physiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience and Neuropharmacology Research
- Protease and Inhibitor Mechanisms
- Memory and Neural Mechanisms
- Signaling Pathways in Disease
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Peptidase Inhibition and Analysis
- Language Development and Disorders
- Neurobiology of Language and Bilingualism
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Effects of Exercise
- Receptor Mechanisms and Signaling
- Mechanisms of cancer metastasis
- Muscle Physiology and Disorders
- Biomarkers in Disease Mechanisms
- Proteoglycans and glycosaminoglycans research
- Cardiomyopathy and Myosin Studies
- Infant Development and Preterm Care
- Nuclear Receptors and Signaling
- Cerebral Palsy and Movement Disorders
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2015-2024
Polish Academy of Sciences
2013-2024
Warsaw University of Life Sciences
2011
Local, synaptic synthesis of new proteins in response to neuronal stimulation plays a key role the regulation morphogenesis. Recent studies indicate that matrix metalloproteinase-9 (MMP-9), an endopeptidase regulates pericellular environment through cleavage its protein components, critical spine morphology and plasticity. Here, we sought determine whether MMP-9 mRNA is transported dendrites for local translation release. First, dendritic transport was seen primary hippocampal cultures...
Abstract Chronic stress is a risk factor for the development of psychopathologies characterized by cognitive dysfunction and deregulated social behaviours. Emerging evidence suggests role cell adhesion molecules, including nectin-3, in mechanisms that underlie behavioural effects stress. We tested hypothesis proteolytic processing nectins matrix metalloproteinases (MMPs), an enzyme family degrades numerous substrates, involved hippocampal induced chronic restraint A reduction nectin-3...
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the regulation of transcription genes that encode proplasticity proteins. In present study, we provide evidence stimulation rat primary cortical neurons with BDNF upregulates matrix metalloproteinase 9 (MMP-9) mRNA and protein levels increases enzymatic activity. The BDNF-induced MMP-9 was dependent on extracellular signal-regulated kinase 1/2 (ERK1/2) pathway c-Fos expression. Overexpression AP-1 dimers led to promoter...
Synaptic cell adhesion molecules regulate signal transduction, synaptic function, and plasticity. However, their role in neuronal interactions with the extracellular matrix (ECM) is not well understood. Here we report that CD44, a transmembrane receptor for hyaluronan, modulates High-resolution ultrastructural analysis showed CD44 was localized at mature synapses adult brain. The reduced expression of affected excitatory transmission primary hippocampal neurons, simultaneously modifying...
Abstract An intra-hippocampus injection of kainic acid serves as a model status epilepticus and the subsequent development temporal lobe epilepsy. Matrix metalloproteinase-9 (MMP-9) is an enzyme that controls remodeling extracellular milieu under physiological pathological conditions. In response to brain insult, MMP-9 contributes synaptic plasticity may play role in progression epileptic condition. Marimastat metalloproteinase inhibitor was tested clinical trials cancer. The present study...
Growth factor and cytokine interactions in myogenesis. Part II. Expression of IGF binding proteins protein kinases essential for myogenesis mouse C2C12 myogenic cells exposed to TNF-α IFN-γ The aim the study was examine potential among IGF-I proinflammatory cytokines, IFN-γ, regulation local bioavailability cellular mediating signals. We investigated levels IGFBP-4, -5, -6, kinase Czeta (PKCζ), p38 extracellular signal-regulated (ERK1/2) differentiating myoblasts. significantly stimulated...
Because of vast variability cochlear implantation outcomes in prelingual deafness treatment, identification good and poor performers remains a challenging task. To address this issue, we investigated genetic variants matrix metalloproteinase 9 (MMP9) brain-derived neurotrophic factor (BDNF) plasma levels MMP-9, BDNF, pro-BDNF that have all been implicated neuroplasticity after sensory deprivation the auditory pathway. We recruited cohort prelingually deaf children, implanted before age 2,...
Desmin expression depends on desmin messenger RNA (mRNA) and ubiquitin proteasome system. This process is poorly understood in dilated cardiomyopathy. The aim of the study was to investigate whether changes mRNA correlate with types cardiomyocytes. Endomyocardial biopsy performed 60 patients (85% men, mean age 46±14 years) heart failure (HF; left ventricular ejection fraction <45%). were analysed histological sections by immunohistochemistry Western blot. determined fluorescent situ...
The retrosplenial cortex (RSC) belongs to the spatial memory circuit, but precise timeline of its involvement and relation hippocampal activation have not been sufficiently described. We trained rats in a modified version T maze with transparent walls distant visual cues induce formation allocentric memory. used two distinct salient contexts associated opposite sequences turns. Switching between allowed us test ability animals utilize information. then applied CatFISH approach probe directed...
Abstract Purpose If before cochlear implantation it was possible to assay biomarkers of neuroplasticity, we might be able identify those children with congenital deafness who, later on, were at risk poor speech and language rehabilitation outcomes. Methods A group 40 aged up 2 years DFNB1-related observed in this prospective cohort study over three follow-up intervals (0, 8, 18 months) after implant (CI) activation. Children assessed for auditory development using the LittlEARS Questionnaire...
Congenitally deaf children who undergo cochlear implantation before 1 year of age develop their auditory skills faster than are implanted later. In this longitudinal study, a cohort 59 were divided into two subgroups according to ages at implantation-below or above old-and the plasma levels matrix metalloproteinase-9 (MMP-9), brain-derived neurotrophic factor (BDNF), and pro-BDNF measured 0, 8, 18 months after implant activation, while development was simultaneously evaluated using LittlEARs...
Matrix Metalloproteinase (MMP) 9 Transcription in Mouse Brain Induced by Fear LearningJournal of Biological ChemistryVol. 288Issue 29PreviewMemory formation requires learning-based molecular and structural changes neurons, whereas matrix metalloproteinase is involved the synaptic plasticity cleaving extracellular proteins and, thus, associated with learning processes mammalian brain. Because mechanisms MMP-9 transcription brain are poorly understood, this study aimed to elucidate regulation...
Abstract Objective: If before cochlear implantation it was possible to assay biomarkers of neuroplasticity, might identify those children with congenital deafness who were at risk poor speech and language rehabilitation outcomes later on. Study Design: a prospective cohort study Methods: group 40 aged up 2 years old DFNB1-reated observed over three follow-up intervals 18 months after implant (CI) activation. Children assessed for auditory development by using the LittlEARS Questionnaire...
Abstract The formation of memories is a complex, multi-scale phenomenon, especially when it involves integration information from various brain systems. We have investigated the differences between novel and consolidated association spatial cues amphetamine administration, using an in-situ hybridisation method to track short-term dynamics during recall testing. found that remote group smaller, but more groups neurons, which consistent with their specialisation. By employing machine learning...
Background If it was possible to assay biomarkers of neuroplasticity might facilitate clinical management deaf implanted children by identifying those among them who are at risk speech and language rehabilitation failure. <i>MMP9</i> is a proteinase involved in underlying different conditions human. Material methods This longitudinal, prospective cohort study 61 congenitally underwent cochlear implantation. We investigated the genetic variants matrix metalloproteinase 9...
Abstract Because of vast variability cochlear implantation outcomes in prelingual deafness treatment, identification good and poor performers remains a challenging task. To address this issue, we investigated genetic variants matrix metalloproteinase 9 ( MMP9 ) brain derived neurotrophic factor BDNF plasma levels MMP-9, BDNF, pro-BDNF that have all been implicated neuroplasticity after sensory deprivation the auditory pathway. We recruited cohort prelingually deaf children, implanted before...