A5007170741- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Mental Health Research Topics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Sexuality, Behavior, and Technology
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Neuroscience and Music Perception
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- LGBTQ Health, Identity, and Policy
- Diet and metabolism studies
- Action Observation and Synchronization
- Sexual function and dysfunction studies
- Obsessive-Compulsive Spectrum Disorders
- Nicotinic Acetylcholine Receptors Study
University of Antwerp
2016-2025
University Psychiatric Hospital
2016-2025
Antwerp University Hospital
2017-2021
Province of Antwerp
2020
Evanston Hospital
2020
Johnson & Johnson (Sweden)
2015
AstraZeneca (United Kingdom)
2015
University of Chile
2015
Lifespan
2015
Ziekenhuisnetwerk Antwerpen Stuivenberg
2013-2014
The 18-kDa translocator protein (TSPO) is increasingly recognized as a molecular target for PET imaging of inflammatory responses in various central nervous system (CNS) disorders. However, the reported sensitivity and specificity TSPO to identify brain processes appears vary greatly across disorders, disease stages, applied quantification methods. To advance potential biomarker evaluate inflammation anti-inflammatory therapies, better understanding its applicability disorders needed. We...
Schizophrenia (SCZ) and bipolar disorder (BD) are associated with immunological dysfunctions that have been hypothesized to lead clinical symptomatology in particular through kynurenine pathway abnormalities. The aim of this study was thus investigate the impact serum metabolite levels on diagnosis, state, symptom severity course a large French transdiagnostic cohort SCZ BD patients. Four patient groups (total n = 507) were included cross-sectional observational study: 1) hospitalized acute...
Docx L, Morrens M, Bervoets C, Hulstijn W, Fransen E, De Hert Baeken Audenaert K, Sabbe B. Parsing the components of psychomotor syndrome in schizophrenia. Objective: Catatonia, extrapyramidal signs, slowing, and (motoric) neurological soft signs are well‐known symptoms This study aims at investigating interrelations between these symptoms. In addition, associations symptoms, clinical cognitive functioning will be studied. Method: An extensive test battery containing (Bush Francis Catatonia...
In this exploratory open label study, we investigated the prevalence of catatonia in an acute psychiatric inpatient population. addition, differences symptom presentation depending on underlying illness were investigated.One hundred thirty patients assessed with Bush-Francis Catatonia Rating Scale (BFCRS), Positive and Negative Syndrome Scale, Young Mania Simpson-Angus Scale. A factor analysis was conducted order to generate six catatonic clusters. Composite scores based principal component...
Introduction. Deficits in the initiation and persistence of goal-directed behaviour are key aspects schizophrenia. In this study, association between these motivational deficits discounting reward value function increasing physical effort costs was investigated.Methods. Effort-based decision-making investigated 40 patients with a DSM-IV diagnosis schizophrenia 30 age- sex-matched healthy control subjects by means an task. To assess negative symptom severity, we made use Scale for Assessment...
Major depressive disorder (MDD) shows large heterogeneity of symptoms between patients, but within particular symptom clusters may show similar trajectories. While and networks have mostly been studied using cross-sectional designs, temporal dynamics patients yield information that facilitates personalized medicine. Here, we aim to cluster through dynamic time warping (DTW) analysis.The 17-item Hamilton Rating Scale for Depression (HRSD-17) was administered every 2 weeks a median 11 in 255...
Schizophrenia and bipolar disorder frequently face significant delay in diagnosis, leading to being missed or misdiagnosed early stages. Both disorders have also been associated with trait state immune abnormalities. Recent machine learning-based studies shown encouraging results using diagnostic biomarkers predictive models, but few focused on immune-based markers. Our main objective was develop supervised learning models predict diagnosis illness schizophrenia only a panel of peripheral...
Activated microglia express the translocator protein (TSPO) on outer mitochondrial membrane. <sup>18</sup>F-PBR111 is a second-generation PET ligand that specifically binds TSPO, allowing in vivo visualization and quantification of neuroinflammation. The aim this study was to evaluate whether test–retest variability healthy controls acceptable detect psychosis-associated neuroinflammatory signal schizophrenia. <b>Methods:</b> Dynamic 90-min scans were obtained 17 male (HCs) 11 schizophrenia...
BDSM is an omnibus term covering a spectrum of activities within bondage/discipline, dominance/submission, and sadism/masochism relationships. To date, practitioners experience stigma due to general unfamiliarity with the practice marginalization this type sexual behavior. Destigmatization occurs partly through knowledge expansion identification stigmatized group. In study Belgian population, we aimed characterize certain aspects socioeconomic status specific preferences individuals...