A5016729649- Mental Health Research Topics
- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Neurodegenerative Diseases
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Fatty Acid Research and Health
- Cardiac Health and Mental Health
- Diet and metabolism studies
- Mental Health Treatment and Access
- Optimism, Hope, and Well-being
- Electroconvulsive Therapy Studies
- Neurological disorders and treatments
- Health disparities and outcomes
- Maternal Mental Health During Pregnancy and Postpartum
- Child Abuse and Trauma
- Psychosomatic Disorders and Their Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Resilience and Mental Health
- Hypothalamic control of reproductive hormones
Leiden University Medical Center
2016-2025
University of Antwerp
2018-2025
The Hague University of Applied Sciences
2023-2024
Leiden University
2012-2024
Loyola University Medical Center
2022-2023
University of Groningen
2019-2023
GGZ inGeest
2023
Health and Human Development (2HD) Research Network
2021
University Medical Center Groningen
2019
Brigham and Women's Hospital
2019
Results from prospective cohort studies and randomized, controlled trials have provided evidence of a protective effect n-3 fatty acids against cardiovascular diseases. We examined the marine eicosapentaenoic acid (EPA) docosahexaenoic (DHA) plant-derived alpha-linolenic (ALA) on rate events among patients who had myocardial infarction.In multicenter, double-blind, placebo-controlled trial, we randomly assigned 4837 patients, 60 through 80 years age (78% men), infarction were receiving...
Significance As complex systems such as the climate or ecosystems approach a tipping point, their dynamics tend to become dominated by phenomenon known critical slowing down. Using time series of autorecorded mood, we show that indicators down are also predictive future transitions in depression. Specifically, persons who more likely have transition, mood slower and different aspects correlated. This supports view system may points where reinforcing feedbacks among web symptoms can propagate...
Adverse effects of long-term cross-sex hormone administration to transsexuals are not well documented. We assessed mortality rates in transsexual subjects receiving hormones.A cohort study with a median follow-up 18.5 years at university gender clinic. Methods Mortality data and the standardized rate were compared general population 966 male-to-female (MtF) 365 female-to-male (FtM) transsexuals, who started hormones before July 1, 1997. Follow-up was least 1 year. MtF received treatment...
In this paper, we characterize major depression (MD) as a complex dynamic system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another network structure. We hypothesize that individuals can be characterized by their own with unique architecture resulting dynamics. With respect architecture, show vulnerable developing MD those strong connections between symptoms: e.g., only night of poor sleep suffices make particular person feel tired. Such networks, when...
Hovens JGFM, Wiersma JE, Giltay EJ, van Oppen P, Spinhoven Penninx BWJH, Zitman FG. Childhood life events and childhood trauma in adult patients with depressive, anxiety comorbid disorders vs. controls. Objective: To investigate the association between events, presence of anxiety, depressive or adulthood. Method: Data are from 1931 participants Netherlands Study Depression Anxiety (NESDA). included divorce parents, early parental loss ‘placed care’, whereas was assessed as experienced...
Background: Major depression is known to be related higher cardiovascular mortality.However, epidemiological data regarding dispositional optimism in relation mortality are scanty.Objective: To test whether subjects who optimistic live longer than those pessimistic.Design: Our analysis formed part of a prospective population-based cohort study the Netherlands (Arnhem Elderly Study).Setting: General community.Participants: aged 65 85 years (999 men and women) completed 30-item validated Dutch...
Article Abstract Background: Childhood trauma is linked to adult depression and might be a risk factor for more chronic course of depression. However, the link between childhood chronicity has not been investigated using large representative sample in which other characteristics, such as severity, age at onset, comorbid psychopathology, were taken into account. Method: Baseline data, collected during 2004 through 2007, drawn from Netherlands Study Depression Anxiety (NESDA). Participants had...
Hovens JGFM, Giltay EJ, Wiersma JE, Spinhoven P, Penninx BWJH, Zitman FG. Impact of childhood life events and trauma on the course depressive anxiety disorders. Objective: Data impact clinical disorders are limited. Method: Longitudinal data were collected from 1209 adult participants in Netherlands Study Depression Anxiety (NESDA). Childhood at baseline assessed with a semi‐structured interview after 2 years DSM‐IV‐based diagnostic Life Chart Interview. Results: At baseline, 18.4% reported...
The majority of Huntington's disease (HD) mutation carriers experience some psychopathology during their lifetime, varying from irritability to psychosis, but prevalences particular symptoms vary widely due diverse study populations in different stages HD and the use assessment methods.The population consisted 1993 15 European countries, all participating observational REGISTRY study. behavioural section Unified Rating Scale was used examine prevalence correlates five neuropsychiatric...
In Volume 73, Issue 5 of Clinical Endocrinology, there was an error in tables 1 and 4 the article by Kalinchenko et al.The CRP values (given mg/l) were reported as 10-fold too high should be divided 10 to yield correct results.
Abstract Background Literature has shown that obesity, metabolic syndrome and inflammation are associated with depression, however, evidence suggests these associations specific to atypical depression. Which of the symptoms driving obesity-related outcomes is unknown. We evaluated between individual depression (both non-atypical) body mass index (BMI), components inflammatory markers. Methods included 808 persons a current diagnosis participating in Netherlands Study Depression Anxiety (67%...
Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology that comorbidity arises due to interplay symptoms shared by both disorders, with overlapping acting as so-called bridges, funneling symptom activation clusters each disorder. This study investigated this testing whether (i) two mental states "worrying" "feeling irritated" functioned bridges in dynamic state networks individuals depression compared either disorder alone,...
Summary objective Sex differences are found in most components of the insulin resistance syndrome and associated cardiovascular risk profile. These attributed to sex‐specific sex steroid profiles, but effects steroids on individual remain incompletely understood. design Prospective, intervention study. subjects In 37 young (age range 16–36 years), nonobese [body mass index (BMI) < 29], transsexual subjects, ethinyl oestradiol (100 µg/day) + cyproterone acetate mg/day) administration were...
Stress is suggested to lead metabolic dysregulations as clustered in the syndrome, but underlying biological mechanisms are not yet well understood.We examined relationship between two main str systems, autonomic nervous system and hypothalamic-pituitary-adrenal (HPA) axis, with syndrome its components.The design was baseline data (yr 2004-2007) of a prospective cohort: Netherlands Study Depression Anxiety (NESDA).The study comprised general community, primary care, specialized mental health...
To investigate androgen effects on the skin pilosebaceous unit, we studied 21 male-to-female transsexuals and 17 female-to-male receiving cross-sex hormones. At baseline after 4, 8, 12 months, hair growth was evaluated by Ferriman-Gallwey score; acne Leeds classification; rate, density, shaft diameter image analysis; sebum production Sebutape. In males, estrogens antiandrogens reduced plasma testosterone to below 1.0 nmol/L. Though all parameters of declined, facial continued. After 4...
<h3>Background:</h3> Dispositional optimism, defined in terms of life engagement and generalized positive outcome expectancies for one's future, may be related to lower cardiovascular mortality. We aimed determine whether dispositional optimism is a stable trait over time it independently mortality elderly men. <h3>Methods:</h3> In cohort study with follow-up 15 years, we included 545 (61.4%) 887 men, aged 64 84 who were free preexisting disease cancer had complete data on risk factors...
Abstract Routine outcome monitoring (ROM) is a method devised to systematically collect data on the effectiveness of treatments in everyday clinical practice. ROM involves documenting through repeated assessments. Assistants are employed who perform baseline assessment comprising standardized diagnostic interview, administration rating scales and completion several self‐report measures by patient. At fixed time intervals, assessments repeated. Dedicated Web‐based software has been developed...