A5048296639- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genetic Associations and Epidemiology
- Digital Mental Health Interventions
- Behavioral Health and Interventions
- Sleep and related disorders
- Non-Invasive Vital Sign Monitoring
- Cognitive Abilities and Testing
- Personality Disorders and Psychopathology
- Mental Health and Psychiatry
- Personality Traits and Psychology
- Hormonal Regulation and Hypertension
- Circadian rhythm and melatonin
- Schizophrenia research and treatment
- Workplace Health and Well-being
- Cardiovascular and exercise physiology
- Birth, Development, and Health
- Treatment of Major Depression
- Blood Pressure and Hypertension Studies
- Resilience and Mental Health
- Psychosomatic Disorders and Their Treatments
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
University of Cambridge
2024
Erasmus University Rotterdam
2007-2023
University of Amsterdam
2019
Netherlands Institute for Advanced Study in the Humanities and Social Sciences
2019
Harvard University
2019
Johns Hopkins University
2018
University Medical Center Utrecht
2007
Vrije Universiteit Amsterdam
2000-2004
Recent literature has introduced (a) the network perspective to psychology and (b) collection of time series data capture symptom fluctuations other varying factors in daily life. Combining these trends allows for estimation intraindividual structures. We argue that networks can be directly applied clinical research practice as hypothesis generating Two computed: a temporal network, which one investigates if symptoms (or relevant variables) predict another over time, contemporaneous same...
Objectives In order to investigate the applicability of routine 10s electrocardiogram (ECG) recordings for time-domain heart rate variability (HRV) calculation we explored what extent these (ultra-)short capture “actual” HRV. Methods The standard deviation normal-to-normal intervals (SDNN) and root mean square successive differences (RMSSD) were measured in 3,387 adults. SDNN RMSSD assessed from (ultra)short 10s(3x), 30s, 120s compared 240s–300s (gold standard) measurements. Pearson’s...
High neuroticism predicts psychopathology and physical health problems. Nongenetic factors, including major life events experiences, explain approximately half of the variance in neuroticism. Conversely, also these experiences. In this study, we aimed to quantify reciprocal causation between experiences gauge magnitude persistence associations. This longitudinal cohort study included 5 assessment waves over 16 years a random sample 296 Dutch participants (47% women) with mean age 34 (SD =...
Background Actigraphy may provide a more valid assessment of sleep, circadian rhythm (CR), and physical activity (PA) than self-reported questionnaires, but has not been used widely to study the association with depression/anxiety their clinical characteristics. Methods Fourteen-day actigraphy data 359 participants current (n = 93), remitted 176), or no 90) composite international diagnostic interview diagnoses were obtained from Netherlands Study Depression Anxiety. Objective estimates...
Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology that comorbidity arises due to interplay symptoms shared by both disorders, with overlapping acting as so-called bridges, funneling symptom activation clusters each disorder. This study investigated this testing whether (i) two mental states "worrying" "feeling irritated" functioned bridges in dynamic state networks individuals depression compared either disorder alone,...
Abstract Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals ( P < 5 × 10 −8 ) from the largest single-stage blood pressure (BP) genome-wide association study to date n = 1,028,980 European individuals). These associations explain 60% single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles polygenic risk scores (PRSs) reveals clinically meaningful differences...
In 1986 we began The Netherlands Twin Register (NTR) by recruiting young twins and multiples a few weeks or months after birth. Currently register around 50% of all newborn in Netherlands. Their parents receive questionnaire at registration afterwards when the children are 2, 3, 5, 7, 10 12 years age. Teachers asked to rate behavior ages years. Adolescent young-adult were recruited through City Councils early 1990s. These twins, their siblings participate longitudinal survey studies that...
The present study estimated the genetic influences on ambulatory systolic and diastolic blood pressure, hypertensive status derived from levels, in a family sample of 535 twins 257 singleton siblings. This "extended twin design" was used to explicitly test possibility that results obtained siblings are different those twins. To examine effects excluding (medicated) subjects, analyses were first performed under strict exclusion (medication and/or pressure >135/85 mm Hg), then without...
Stress early in life is a known risk factor for the development of affective disorders later life. Epigenetic mechanisms, such as DNA methylation, may have an important role mediating that risk. Recent epigenetic research reported on long-term relationship between traumatic stress childhood and methylation adulthood. In this study, we examined impact various types (perinatal stress, stressful events (SLEs) youth experiences) glucocorticoid receptor gene (NR3C1) blood population sample 468...
Altered cortisol response is a vulnerability marker for variety of stress-related diseases and psychiatric disorders. Childhood adversity has been shown to modify this response, but evidence inconsistent. Effects may differ depending on the timing exposure, or due interplay between pre/postnatal later adversities. The present study examined influence during different timeframes (pre/postnatal, ages 0–5, 6–11, 12–13, 14–15 years), interaction adolescents' stress response. Four salivary...
Background High neuroticism is prospectively associated with psychopathology and physical health. However, within-subject changes in due to life experiences (LEs) or state effects of current are largely unexplored. In this 2-year follow-up study, four hypotheses were tested: (1) positive LEs (PLEs) decrease negative (NLEs) increase neuroticism; (2) LE-driven change partly long-lasting; (3) independent anxiety/depression; (4) childhood adversity (before age 16 years) moderates the influence...
Neuroticism and extraversion are affected by depressive disorder state. Less is known about state effects on conscientiousness, agreeableness openness. Furthermore, of anxiety disorders personality have been far less studied than those disorder. Here, we aim to determine the extent change in all five traits associated with occurrence or recovery from disorders. Using Composite International Diagnostic Interview (CIDI) at baseline two-year follow-up, respondents Netherlands Study Depression...
One of the promises experience sampling methodology (ESM) is that a statistical analysis an individual's emotions, cognitions and behaviors in everyday-life could be used to identify relevant treatment targets. A requisite for clinical implementation outcomes such person-specific time-series analyses are not wholly contingent on researcher performing them. To evaluate this, we crowdsourced one individual patient's ESM data 12 prominent research teams, asking them what symptom(s) they would...
Neuroticism is a predictor of many health problems. To study the determinants within–subject change in neuroticism, three hypotheses were tested: (i) subjects who experienced stressful life events (SLEs) show an increase neuroticism; (ii) high baseline neuroticism moderated this effect; and (iii) recent SLEs had greater impact on than distant SLEs. Data came from Finnish Twin Cohort. data collected 1975 1981 (n = 21 085). By entering as for at follow–up, outcome measure was neuroticism....
Abstract Background There is increasing interest in day-to-day affect fluctuations of patients with depressive and anxiety disorders. Few studies have compared repeated assessments positive (PA) negative (NA) across diagnostic groups, fluctuation patterns were not uniformly defined. The aim this study to compare a current episode or disorder, remitted controls, using instability as core concept but also describing other measures variability adjusting for possible confounders. Methods...
In the proposed symptom network approach to psychopathology, psychiatric disorders are assumed result from (causal) interplay between symptoms. By implementing this we explored whether individual feedback on dynamics complements current categorical classification and treatment. The aim of proof-of-principle case-study was explore feasibility, acceptability usability transdiagnostic approach.A female patient, aged 67, suffering treatment resistant anxious depressive symptoms treated in our...
The past decades of research have seen an increase in statistical tools to explore the complex dynamics mental health from patient data, yet application these clinical practice remains uncommon. This is surprising, given that reasoning, e.g., case conceptualizations, largely coincides with dynamical system approach. We argue gap between and can partly be explained by fact current estimation techniques disregard theoretical practical considerations relevant psychotherapy. To address this...