A5112258238- Sleep and related disorders
- Cancer, Hypoxia, and Metabolism
- Sleep and Wakefulness Research
- Cancer, Lipids, and Metabolism
- Acute Myeloid Leukemia Research
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- RNA modifications and cancer
- Sleep and Work-Related Fatigue
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Bipolar Disorder and Treatment
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Histone Deacetylase Inhibitors Research
- Bioinformatics and Genomic Networks
- T-cell and B-cell Immunology
- Cancer-related gene regulation
- Peroxisome Proliferator-Activated Receptors
- Gene Regulatory Network Analysis
- Epigenetics and DNA Methylation
- Effects of Radiation Exposure
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Fondation FondaMental
2024-2025
Hôpital Albert-Chenevier
2025
Nihon University
2018-2024
Assistance Publique – Hôpitaux de Paris
2024
Institut Mondor de Recherche Biomédicale
2024
Inserm
2024
Université Paris-Est Créteil
2024
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2024
Keio University
2017-2023
Osaka University
2023
Significance Metabolic reprogramming is one of the hallmarks cancer. However, underlying mechanisms that regulate cancer metabolism are poorly understood. Here we performed multiomics-based analysis paired normal–tumor tissues from patients with colorectal cancer, which revealed protooncogene protein MYC regulated global metabolic by modulating 215 reactions. Importantly, this occurred in a manner not associated specific gene mutations carcinogenesis. For many years, small-molecule or...
Leukemia cells in the bone marrow must meet biochemical demands of increased cell proliferation and also survive by continually adapting to fluctuations nutrient oxygen availability. Thus, targeting metabolic abnormalities leukemia located is a novel therapeutic approach. In this study, we investigated role adipocytes supporting growth leukemic blasts. Prevention starvation-induced apoptosis adipocytes, as well molecular mechanisms involved process, was using various analytic techniques....
Tumor recurrence is attributable to cancer stem-like cells (CSCs), the metabolic mechanisms of which currently remain obscure. Here, we uncovered critical role folate-mediated one-carbon (1C) metabolism involving mitochondrial methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) and its downstream purine synthesis pathway. MTHFD2 knockdown greatly reduced tumorigenesis properties, were associated with nucleotide deficiency, caused marked accumulation 5-aminoimidazole carboxamide ribonucleotide...
This study aimed to determine whether both subjective sleep quality and duration are directly associated with of life (QOL), as well indirectly QOL through insomnia symptoms. Individuals aged 20–69 years without mental illness (n = 9305) were enrolled in this web-based cross-sectional survey. The Short Form-8 was used assess physical QOL. We the Pittsburgh Sleep Quality Index (PSQI) extracted items related duration. Insomnia symptoms also from PSQI. hypothesized models tested using...
We explored the role of Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 pancreatic β cells (Fh1βKO mice) appear normal for 6-8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression mitochondrial or cytosolic FH not deletion Hif1α Nrf2. Progressive hyperglycemia Fh1βKO mice led to dysregulated metabolism cells, a decrease glucose-induced ATP production, electrical activity,...
Abstract Adipocytes are the prevalent stromal cell type in adult bone marrow (BM), and leukemia cells continuously adapt to deficiency of nutrients acquiring chemoresistant profiles BM microenvironment. We have previously shown that fatty acid metabolism is a key energy pathway for survival acute myeloid (AML) adipocyte-abundant The novel β-oxidation (FAO) inhibitor avocatin B, an odd-numbered carbon lipid derived from avocado fruit, induced apoptosis growth inhibition mono-cultured AML...
Adiponectin is a cytokine secreted from adipocytes and regulates metabolism. Although serum adiponectin levels show diurnal variations, it not clear if the effects of are time-dependent. Therefore, this study conducted locomotor activity analyses various metabolic studies using knockout (APN (-/-)) APN (+/+) mice to understand whether circadian rhythm glucose lipid We observed that gene deficiency does affect rhythmicity core clock genes expression in several peripheral tissues. In contrast,...
Abstract Associations of sleep duration with human health could differ depending on whether is restorative. Using data from 5804 participants the Sleep Heart Health Study, we examined longitudinal association restfulness combined polysomnography-measured total time (TST) or in bed (TIB), representing different sleeping behaviors, all-cause mortality. Among middle-aged adults, compared restful intermediate TST quartile, lowest quartile feeling unrested was associated higher mortality (hazard...
Introduction Preventing depression among nurses is a critical issue from the perspective of occupational welfare, but associations between depressive symptoms in and stress-coping strategies remain unclear. Methods In present study, an epidemiological study was conducted based on cross-sectional questionnaire survey. Data obtained 2,534 female working at three general hospitals Tokyo, Japan, were analyzed. Participants completed comprising 42 items, including strategies, addition to...
The concentrations of insulin selectively regulate multiple cellular functions. To understand how are interpreted by cells, we constructed a trans-omic network action in FAO hepatoma cells using transcriptomic data, western blotting analysis signaling proteins, and metabolomic data. By integrating sensitivity into the network, identified selective networks stimulated high low doses insulin, denoted as induced basal signals, respectively. signal was transmitted through pathway involving Erk...
Tolerance to severe tumor microenvironments, including hypoxia and nutrient starvation, is a common feature of aggressive cancer cells can be targeted. However, metabolic alterations that support upon starvation are not well understood. Here, by comprehensive metabolome analyses, we show glutamine deprivation leads phosphoethanolamine (PEtn) accumulation in via the downregulation PEtn cytidylyltransferase (PCYT2), rate-limiting enzyme phosphatidylethanolamine biosynthesis. correlated with...
Individual dimensions of sleep health, including satisfaction, sleepiness/alertness, timing, efficiency, and duration, are associated with depression. We investigated whether a composite health score is symptoms depression among Japanese female hospital nurses.
Abstract A discrepancy in subjective and objective estimations of sleep duration, which often diverge, could have long-term adverse effects on health outcomes older adults. Using data from 2674 adult men (≥ 65 years age) the Osteoporotic Fractures Men Sleep Study, we assessed longitudinal association between misperception index (MI), calculated as MI = (objective duration – duration)/objective all-cause mortality. During follow-up with a mean (standard deviation) 10.8 (4.2) years, 1596...
Decitabine (DAC) is clinically used to treat myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Our genome-wide CRISPR-dCas9 activation screen using MDS-derived AML cells indicates that mitotic regulation critical for DAC resistance. strongly induces abnormal mitosis (abscission failure or tripolar mitosis) in human tumors at clinical concentrations, especially those with TP53 mutations antecedent hematological disorders. This DAC-induced disruption apoptosis are significantly...
Nonrestorative sleep (NRS), defined as insufficiently rested or refreshed sleep, is considered to play an important role in the development of depression. The aim this study investigate predictive ability insomnia-related symptoms, including NRS, for incident depressive symptoms (DEPs) a longitudinal manner.We used data 1196 samples aged 18-64 years who participated both Hispanic Community Health Study/Study Latinos conducted 2008-2010 and follow-up (Sueño Ancillary Study) 2010-2013. DEPs...
Immune dysregulation is an important aspect of schizophrenia (SZ) and bipolar disorders (BD) pathophysiology, including not only inflammatory but also autoimmune process reflective abnormal humoral immune responses. Given that B cell-activating factor (BAFF) integral lymphocyte regulation, the current study investigated BAFF in SZ BD. 255 patients, 407 BD patients 185 healthy controls (HC) were across three aspects soluble (sBAFF) by (i) comparing sBAFF circulatory levels SZ, HC, (ii)...
In psychiatric disorders, comorbid depressive symptoms are associated with clinically important issues such as reduced quality of life, a poor prognosis, and increased suicide risk. Previous studies have found close relationship between insomnia in major disorder (MDD), that actively improving heightens the improvement symptoms. This study aimed to investigate whether association is also other disorders besides MDD. The subjects were 144 patients MDD (n = 71), schizophrenia 25), bipolar 22),...
Growth regulation by estrogen in breast cancer 1 (GREB1) is involved hormone-dependent and -independent tumor development (e.g., hepatoblastoma). In this study, we found that a GREB1 splicing variant, isoform 4 (Is4), which encodes C-terminal half of full-length GREB1, specifically expressed via microphthalmia-associated transcription factor (MITF) melanocytic melanoma, two MITF-binding E-box CANNTG motifs at the 5'-upstream region exon 19 are necessary for Is4 transcription. MITF were...
Background Brain-derived neurotrophic factor (BDNF) is widely expressed in the brain and plays an important role neuronal maintenance, plasticity, neurogenesis. Prior studies have found that decreased serum BDNF levels are associated with perceived stress, depression, or sleep disturbances humans. Study objectives To elucidate whether genotype were pattern healthy young adults. Methods The study group consisted of 79 paid volunteers (45 men, 34 women) aged 20 to 29 years. Serum measured...
Mantle cell lymphoma (MCL) is an aggressive B-cell with poor prognosis, characterized by aberrant expression of growth-regulating and oncogenic effectors requiring novel anticancer strategies. The nuclear transporter exportin-1 (XPO1) highly expressed in MCL associated its pathogenesis. mTOR signaling, a central regulator metabolism, frequently activated also important therapeutic target this cancer. This study investigated the antitumor effects molecular/metabolic changes induced...
The effects of the high-dose ionizing radiation used in radiotherapy have been thoroughly demonstrated vitro and vivo. However, low-dose (LDIR) such as computed tomography-guided biopsies X-ray fluoroscopy on skin cells remain controversial. This study investigated molecular LDIR human primary keratinocytes (HPKs) U937 cells, monocytes-like cell lines. These were exposed to 0.1 Gray (Gy) LDIR. modulation transcription was assessed using a cDNA array, protein expression after exposure...
Abstract Background Insomnia is known to be a major risk factor for incident hypertension. Nonrestorative sleep (NRS), which refers insufficiently rested sleep, has reported associate with various diseases. This study aimed investigate the longitudinal association between insomnia-related symptoms including NRS and hypertension 1 – 2 years later by age group (young, 18–39 middle-age, 40–64 years) using existing cohort data involving Hispanics/Latinos. Methods included 1100 subjects who had...