A5103137198- Medical Imaging Techniques and Applications
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Muscle activation and electromyography studies
- Sports Performance and Training
- Balance, Gait, and Falls Prevention
- Folate and B Vitamins Research
- Nutrition and Health in Aging
- Asthma and respiratory diseases
- Cerebral Palsy and Movement Disorders
- HIV Research and Treatment
- Phagocytosis and Immune Regulation
- Sports injuries and prevention
- Health and Wellbeing Research
- Spine and Intervertebral Disc Pathology
- Advanced MRI Techniques and Applications
- Anesthesia and Pain Management
- Eosinophilic Esophagitis
- Viral Infections and Vectors
- Pelvic floor disorders treatments
- Genomics, phytochemicals, and oxidative stress
- Heart Rate Variability and Autonomic Control
- Hepatitis B Virus Studies
- Microbial Metabolism and Applications
- Alcohol Consumption and Health Effects
Shukutoku University
2025
National Institute of Infectious Diseases
2008-2024
Teikyo University
2024
University of Fukui
2015-2024
Brown University
2024
National Center For Child Health and Development
2019-2023
Yokohama City University
2015-2023
Sakakibara Hospital
2020
Koshigaya Municipal Hospital
2019
Takasago (Japan)
2017
Objectives To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass strength community‐dwelling elderly sarcopenic women. Design Randomized controlled trial. Setting Urban community T okyo, J apan. Participants One hundred fifty‐five women aged 75 older were defined as randomly assigned to one four groups: (exercise + AAS ; n = 38), (n 39), ( or health education HE 39). Intervention The group attended a 60‐minute comprehensive training program twice...
In this study, we establish that cholesterol and sphingolipid associated with hepatitis C virus (HCV) particles are important for virion maturation infectivity. a recently developed culture system enabling study of the complete life cycle HCV, mature virions were enriched as assessed by molar ratio to phospholipid in cell membranes. Depletion from or hydrolysis virion-associated sphingomyelin almost completely abolished HCV Supplementation cholesterol-depleted exogenous enhanced infectivity...
Aim: To investigate the effects of exercise and/or tea catechin supplementation on muscle mass, strength and walking ability in elderly Japanese women with sarcopenia. Methods: A total 128 aged over 75 years were defined as sarcopenic randomly assigned into four groups: ( n = 32), 32) or health education 32). The group attended a 60‐min comprehensive training program twice week ingested 350 mL beverage fortified daily for 3 months. Body composition was determined by bioelectrical impedance...
Epidemiological studies demonstrated that cleaning work and frequent use of products are risk factors for asthma. Laundry detergents have been reported to epithelial barrier-opening effects. However, whether laundry directly induce airway inflammation its mechanisms in vivo remain be elucidated.Two commercial two commonly used surfactants cosmetics (sodium lauryl sulfate sodium dodecyl benzene sulfonate) were intranasally administered mice. Lungs analyzed using flow cytometry, histology,...
Background. An ecological analysis found that the docosahexaenoic acid content in mother's milk and seafood intake were inversely correlated with postpartum depression. This prospective study investigated relationship of consumption selected high-fat foods specific types fatty acids risk Method. The subjects 865 Japanese women. Dietary data obtained from a self-administered diet history questionnaire during pregnancy. Edinburgh Postnatal Depression Scale (EPDS) was used for evaluation...
Phosphatidylserine (PS) has many important biological roles, but little is known about its role in plants, partly because of low abundance. We show here that PS enriched Arabidopsis floral tissues and genetic disruption biosynthesis decreased heterozygote fertility due to inhibition pollen maturation. At1g15110, designated PSS1, encodes a base-exchange-type synthase. Escherichia coli cells expressing PSS1 accumulated the presence l-serine at 23°C. Promoter-GUS assays showed expression...
Recombinant adenovirus (Adv)-mediated gene transduction is a powerful technology for cancer therapy. In this article, we report the generation of fiber-mutant Adv vector, using genomic DNA–terminal protein complex (DNA–TPC) cotransfection method. First, construct in plasmid carrying right-side two-thirds human type 5 (Ad5) genome (pTR) was cotransfected with Ad5 DNA–TPC, yielding recombinant desired fiber mutation. The DNA–TPC from mutant then utilized to produce second-step an expression...
The human hepatoma-derived HuH-7 cell line and its derivatives (Huh7.5 Huh7.5.1) have been widely used as a convenient experimental substitute for primary hepatocytes. In particular, these lines represent host cells suitable propagating the hepatitis C virus (HCV) in vitro. Huh7.5.1-8 line, subline of Huh7.5.1, can propagate HCV more efficiently than parental cells. To provide genomic information cells' quality control, we performed whole-genome sequencing identified their characteristic...
Wearable devices have the potential to promote a healthy lifestyle; however, studies on use of wearable in monitoring health older adults are limited. We aimed investigate relationship sleep and activity data with status among adults. Fifty-five community-dwelling were asked wear wristwatch-type device (the Pulsense [PS]) measure home blood pressure (HBP) over period 5-7 consecutive days. Deep-sleep duration, physical mental body-movement duration obtained from PS using special software....
An epidural injection of physiological saline solution after spinal anesthesia may produce a higher level analgesia than alone because volume effect.The purpose this study was to clarify the effect caused by anesthesia. Twenty patients undergoing combined and for elective surgery whose analgesic levels did not reach surgical regions 10 min at L4-5 interspace were randomly assigned two groups. The control group (n = 10) received no injection. mL through an catheter L2-3 or L3-4 In group, 15...
QSAR analysis has been used to identify the essential structural requirements for increasing inhibitory activities of selected bufadienolides from Chinese drug Ch'an Su (and other sources) against primary liver carcinoma cell line PLC/PRF/5 (PLC) and derived colchicine-resistant (COL). The variable substituent domain proposed pharmacophore was investigated using a Comparative Molecular Field Analysis (CoMFA) approach. A model with considerable predictive ability obtained. In addition, CoMFA...
An epidural injection of physiological saline solution after spinal anesthesia may produce a higher level analgesia than alone because volume effect.The purpose this study was to clarify the effect caused by anesthesia. Twenty patients undergoing combined and for elective surgery whose analgesic levels did not reach surgical regions 10 min at L4-5 interspace were randomly assigned two groups. The control group (n = 10) received no injection. mL through an catheter L2-3 or L3-4 In group, 15...
Atopic eczema is most commonly diagnosed in children under the age of 5 yr. Environmental factors during pregnancy or early life may confer risk for childhood atopic eczema. The present prospective study examined relationship perinatal home environment and suspected among Japanese infants 1. Study subjects were 865 parent–child pairs. term ‘suspected eczema’ was used to define an outcome based on our questionnaire at 2–9 months postpartum. Adjustment made maternal age, gestation, family...
Background.Maintenance of physical performance could improve the quality life in old age. Recent studies suggested a beneficial relationship between antioxidant vitamin (eg, C) intake and elderly people. The purpose this study was to examine plasma C concentration among Japanese community-dwelling women.
Aims Urinary incontinence (UI) and musculoskeletal conditions, particularly low back pain (LBP), osteoarthritis (OA), are common problems that have been associated with mobility limitations future dependence in activities of daily living the elderly. The purpose this study was to explore relationship between UI, UI types, conditions elderly community-dwelling women. Methods A cross-sectional performed on 1,399 Japanese women aged 75–84 years. Face-to-face interviews, body composition,...
Tolerance to severe tumor microenvironments, including hypoxia and nutrient starvation, is a common feature of aggressive cancer cells can be targeted. However, metabolic alterations that support upon starvation are not well understood. Here, by comprehensive metabolome analyses, we show glutamine deprivation leads phosphoethanolamine (PEtn) accumulation in via the downregulation PEtn cytidylyltransferase (PCYT2), rate-limiting enzyme phosphatidylethanolamine biosynthesis. correlated with...
Phosphatidylserine (PtdSer) in mammalian cells is synthesized through the exchange of free l-serine for polar head group (base) preexisting phospholipid. We previously showed presence two different enzymes catalyzing serine base Chinese hamster ovary (CHO) and isolated cDNA one enzymes, PtdSer synthase (PSS) I, which also catalyzes moiety phospholipid(s) ethanolamine choline. In this study, we cloned a CHO cDNA, designated aspssB, encodes protein exhibiting 32% amino acid sequence identity...
[Purpose] The aim of this study was to identify the age-associated changes in gait speed, stride length, cadence and step width, examine relationship between these variables with a history falls life-space experience among elderly people. [Subjects] participants were 848 healthy adults (mean age 80 years, range 73-91, 76.8% women) living independently at home. [Methods] Gait width measured normal pace using WalkWay, device for measuring distribution foot pressure during walking. Any previous...
Aim To determine the long‐term effects of interventions carried out for improvement muscle mass, strength, walking ability and fall rate, 4 years after completion intervention. Methods Out 304 elderly sarcopenic women aged over 75 years, 155 participated in an intervention 149 were excluded from Those considered as non‐participants included analysis. Follow‐up data available 259 (135 participants; 124 non‐participants). Muscle mass was determined by bioelectrical impedance Physical fitness...