A5057007339- Breast Cancer Treatment Studies
- Cancer-related gene regulation
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Biomarkers in Disease Mechanisms
- Cerebrovascular and genetic disorders
- Glioma Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Income, Poverty, and Inequality
- Fiscal Policy and Economic Growth
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- Economic Growth and Productivity
- Bone health and treatments
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Mass Spectrometry Techniques and Applications
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
Chuo University
2015-2023
Dokkyo Medical University
2007-2022
Kumamoto University
2011-2021
Breast Center
2021
Tochigi Cancer Center
2021
National Cancer Center
2019-2021
Kumamoto City Hospital
2009-2020
Yotsuya Medical Cube
2020
National Cancer Centre Japan
2019
National Cancer Research Institute
2017
The choice of adjuvant systemic therapy is based on targeted in line with the St. Gallen Consensus meeting. In addition to traditional parameters, panel recommended use proliferation markers and multigene assays. purpose present study was evaluate clinical significance proliferative activity using Ki-67 index as a prognostic marker predictor recurrence time breast cancer patients. measured 3,652 cases primary from 1987 2009. Out these patients, 2,638 were evaluated simultaneously for...
Abstract Tumor-associated macrophages (TAMs) have recently been reported as an important factor in tumor growth and the progression of cancer. The prognostic significance localizations densities TAMs triple negative cancer (TNC) breast is not well understood. aim this study was to assess subtype TNC examine their clinicopathological features. based on 107 cases operated at Dokkyo Medical University Hospital using pan-macrophage marker CD68 M2 macrophage CD163 stroma (TS) nest (TN),...
Abstract Glioblastoma is one of the most devastating human malignancies for which a novel efficient treatment urgently required. This pre–clinical study shows that eribulin, specific inhibitor telomerase reverse transcriptase ( TERT )‐RNA‐dependent RNA polymerase, an effective anticancer agent against glioblastoma. Eribulin inhibited growth 4 promoter mutation‐harboring glioblastoma cell lines in vitro at subnanomolar concentrations. In addition, it suppressed cells transplanted...
Abstract Analyzing the cytotoxic functions of effector cells, such as NK cells against target cancer is thought to be necessary for predicting clinical efficacy antibody-dependent cellular cytotoxicity (ADCC) -dependent antibody therapy. The 51 Cr release assay has long been most widely used method quantification ADCC activity. However, reproducibilities these assays are not adequate and they do allow evaluation lysis susceptibilities distinct cell types within population. In this study, we...
Recently, research into the development of new targeted therapies has focused on specific genetic alterations to create advanced, more personalized treatment. One target genes, fibroblast growth factor receptor‐1 ( FGFR 1 ), been reported be amplified in estrogen receptor ER )‐positive subtype breast cancer, and is considered one possible mechanism endocrine resistance through cross‐talk between signaling. We performed a comprehensive analysis at levels gene copy number, transcript protein...
Abstract In the development of anticancer drugs, drug concentration measurements in target tissue have been thought to be crucial for predicting efficacy and safety. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is commonly used determination average concentrations; however, complete loss spatial information occurs. Mass imaging (MSI) has recently applied as an innovative tool detection molecular distribution pharmacological agents heterogeneous targets. This study examined...
Tolerance to severe tumor microenvironments, including hypoxia and nutrient starvation, is a common feature of aggressive cancer cells can be targeted. However, metabolic alterations that support upon starvation are not well understood. Here, by comprehensive metabolome analyses, we show glutamine deprivation leads phosphoethanolamine (PEtn) accumulation in via the downregulation PEtn cytidylyltransferase (PCYT2), rate-limiting enzyme phosphatidylethanolamine biosynthesis. correlated with...
Cylindromatosis (CYLD) is a tumor suppressor that regulates signaling pathways by acting as deubiquitinating enzyme. CYLDdown-regulation occurred in several malignancies, with tumor-promoting effects. Although we found loss of CYLD expression hypoxic regions human glioblastoma multiforme (GBM), the most aggressive brain tumor, biological roles GBM remain unknown. This study aimed to determine significance down-regulation progression and therapy. mRNA transcription was dramatically...
Abstract Background Tumor-infiltrating lymphocytes (TILs) have recently been reported as an important factor in the tumor microenvironment and influence growth progression of cancer. However, relationship between immune cell subpopulations, such CD4+, CD8+, FOXP3+, breast cancer, especially triple negative carcinoma (TNC), remains unclear. Methods The subjects were 107 patients with TNC that surgically resected at Dokkyo Medical University Hospital 2006 2018. expression FOXP3+ was evaluated...
The phosphoinositide-3-kinase (PI3K) pathway is commonly deregulated in breast cancer through several mechanisms, including PIK3CA mutation and loss of phosphatase tensin homolog (PTEN) inositol polyphosphate 4-phosphatase-II (INPP4B). We aimed to evaluate the predictive relevance these biomarkers trastuzumab efficacy HER2-positive disease. evaluated effect 43 patients with HER2-overexpression who received neoadjuvant treatment. was examined by direct sequencing digital PCR assay, copy...
// Takuya Nakamura 1,* , Satoru Shinriki 2,* Hirofumi Jono 3 Jianying Guo 4 Mitsuharu Ueda Mitsuhiro Hayashi 5 Satoshi Yamashita Andries Zijlstra 6 Hideki Nakayama 1 Akimitsu Hiraki Masanori Shinohara and Yukio Ando Department of Oral Maxillofacial Surgery, Graduate School Medical Sciences, Kumamoto University, Kumamoto, Japan 2 Laboratory Medicine, Clinical Pharmaceutical University Pharmacy, Hospital, Neurology, Breast Endocrine Pathology, Microbiology, Immunology, Vanderbilt Center,...
Although drug distribution in tumor tissues has a significant impact on efficacy, conventional pharmacokinetic analysis some limitations with regard to its ability provide comprehensive assessment of tissue distribution. Erlotinib is tyrosine kinase inhibitor that acts the epidermal growth factor receptor; however, it unclear how this histologically distributed lung cancer. We used matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and liquid...
// Saori Fujiwara 1,* , Mutsuko Yamamoto-Ibusuki Yutaka Yamamoto 1,2 Satoko 1 Mai Tomiguchi Takashi Takeshita Mitsuhiro Hayashi Aiko Sueta and Hirotaka Iwase Department of Breast Endocrine Surgery, Graduate School Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Japan 2 Molecular Targeting Therapy for Cancer, * These Authors are equally contributed to this work Correspondence: Iwase, email: Keywords : HER4, 4ICD, Splicing variants, cancer, therapy, Prognosis Received...
Based on the 2008–2010 S usenas panel data, this study examines expenditure inequality from spatial perspectives in I ndonesia, using three decomposition methods: (i) a conventional Theil index decomposition; (ii) an alternative T heil proposed by E lbers et al . (2008); and (iii) B linder− O axaca decomposition. Our results show that overall per capita increases between 2008 2010, which coincides with rising trend official G ini coefficient. The contribution of within urban rural areas to...