A5043351415- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Surgical Oncology
- Fetal and Pediatric Neurological Disorders
- Lung Cancer Research Studies
- Spinal Dysraphism and Malformations
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Anatomy and Medical Technology
- Bone Tumor Diagnosis and Treatments
- Pituitary Gland Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Cancer Immunotherapy and Biomarkers
- Moyamoya disease diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Cancer Mechanisms and Therapy
Shizuoka Cancer Center
2015-2024
Shizuoka Medical Center
2019-2020
University of Toyama
2006-2013
Toyama University Hospital
2008-2012
Tohoku Medical and Pharmaceutical University
1999-2008
Aomori Prefectural Central Hospital
2006-2007
Teikyo University
2007
Akita University
2007
The University of Tokyo
2007
University of Yamanashi
2007
The authors attempted to determine independent predictors that contribute the recurrence of chronic subdural hematoma (CSDH).A total 105 consecutive patients who underwent surgery for CSDH were included in this study. Eleven a repeated operation because recurred. Univariate and multivariate analyses performed assess relationships among various variables recurrence. Finally, four found be independently associated with CSDH: 1) absence multiplicity cavities on CT scans; 2) presence history...
The goal of this study was to report on the surgical management skull base chordomas and evaluate both short- long-term treatment outcomes.The authors retrospectively studied data from 49 patients who had undergone consecutive surgeries at a single institution. They also analyzed patterns chordoma extension. Complications surgery-related morbidity were recorded. A Kaplan-Meier analysis performed determine survival rates in 5 10 years after their first surgery. Operative approaches selected...
Abstract Purpose: Humanized mouse models using NOD/Shi-scid-IL2rγnull (NOG) and NOD/LtSz-scid IL2rγnull (NSG) are associated with several limitations, such as long incubation time for stem cell engraftment the development of xenograft versus host disease in mice injected peripheral blood mononuclear cells (PBMCs). To solve problems, we used humanized major histocompatibility class I- II-deficient NOG (referred to NOG-dKO) evaluate antitumor effect anti-programmed death-1 (PD-1) antibody....
Carotid endarterectomy (CEA) is the main treatment for atherosclerotic plaque of cervical internal carotid artery. The surgical anatomy arteries was studied in triangle 49 cadavers. bifurcation located at level lower third C-3. superior thyroid artery arose from anterior wall external 70% specimens and distal portion common 30%. lingual as a separate trunk between origins facial 81% specimens, with 18%, 1%. occipital posterior aspect above origin 57% 32%, below 11%. positioned low crossed by...
This study aimed to establish the Japanese Cancer Genome Atlas (JCGA) using data from fresh frozen tumor tissues obtained 5143 cancer patients, including those with colorectal (31.6%), lung (16.5%), gastric (10.8%) and other cancers (41.1%). The results are part of a single-center called "High-tech Omics-based Patient Evaluation" or "Project HOPE" conducted at Shizuoka Center, Japan. All DNA samples most RNA were analyzed whole-exome sequencing, gene panel fusion sequencing microarray...
OBJECTIVE The median postoperative survival duration of patients with brain metastases who undergo tumor resection is 12 months. Most these die systemic or the progression primary cancer but not metastases. criteria for indicating are still controversial. Systemic assessment restricted, especially in need emergent management their large-size life-threatening neutrophil-to-lymphocyte ratio (NLR) reported to correlate time progression-free various cancers. However, NLR has been assessed impact...
Abstract Purpose: The B7 homolog 4 (B7-H4, VTCN1) is an immune checkpoint molecule that negatively regulates responses and known to be overexpressed in many human cancers. Previously, we generated a mouse anti-human B7-H4 mAb did not have significant antitumor effect vivo probably because of instability. In this study, designed B7-H4/CD3-bispecific antibody (BsAb) investigated its activity vitro using humanized model. Experimental Design: cDNAs the antibody-binding fragment...
The authors report their investigation on the current status of neuroendoscopic biopsy for ventricular and paraventricular tumors as well treatment associated hydrocephalus in Japan.Patients who had undergone therapeutic neuroendoscopy between 2005 2009 were included this study. main items examined age; sex; localization tumor; pathological diagnosis using biopsy; presence, treatment, efficacy hydrocephalus; perioperative complications; activities daily living (ADL) before after...
Neuronavigation has become an effective therapeutic modality and is used routinely for intra-axial tumor removal. This retrospective study was conducted to evaluate the clinical impact of neuronavigation image-guided extensive resection adult patients with supratentorial malignant astrocytomas. Between 1990 2002, 76 pathologically confirmed astrocytomas underwent craniotomy removal tumors at Toyama Medical Pharmaceutical University Hospital. Of these patients, 42 were treated using...
The intracranial internal carotid artery (ICA) is a muscular and lacks external elastic lamina (EEL). Stenosis of the ICA relatively uncommon, but most common site cavernous portion. characteristics arterial wall structures were examined using serial 3-mm sections 32 ICAs obtained from 50 cadavers to identify where EEL disappeared. portions intima exhibited thickening also determined. Both (IEL) observed in all specimens petrous portion ICA. Only IEL was intradural had disappeared 31...
<b>Objectives</b> Cerebrospinal fluid (CSF) leakage is an undesirable complication of skull base surgery. We used dried human amniotic membrane (AM) as a patch graft for dural repair to determine its efficacy in preventing CSF leakage. <b>Design</b> Frontoparietal craniotomy and removal dura were performed 20 Wistar rats. A AM was placed cover the defect without suturing 16 animals. In four animals, expanded polytetrafluoroethylene implanted. At 2 weeks 1, 3, 6 months, histological...
Background/Aim: Glioblastoma multiforme (GBM) is an intractable tumor that has a very poor prognosis despite intensive treatment with temozolomide plus radiotherapy. Patients and Methods: Sixteen newly diagnosed patients high-grade gliomas were enrolled in phase II study of the α-type-1 DC vaccine. Briefly, DCs obtained from culture enriched monocytes presence cytokine cocktail, pulsed cocktail 5 synthetic peptides cryopreserved until injection into patients. Results: The amount IL-12...
The intrinsic radioresistance of certain cancer cells may be closely associated with the constitutive activation nuclear factor-kappa B (NF-kappaB) activity, which lead to protection from apoptosis. Recently, nonapoptotic cell death, or autophagy, has been revealed as a novel response ionizing radiation. In present study, authors analyzed effect pitavastatin potential inhibitor NF-kappaB on radiosensitivity A172, U87, and U251 human glioma lines.The pharmacological inhibition was achieved...
Glioblastoma multiforme (GBM) is one of the most malignant and aggressive tumors has a very poor prognosis, with median survival time less than 2 years. Once recurrence develops, there are few therapeutic approaches to control growth glioblastoma. In particular, temozolomide (TMZ)-resistant (TMZ-R) GBM difficult treat, novel approach overcome resistance eagerly awaited. Previously, we reported small molecule inhibitor STAT3 dimerization, STX-0119, as cancer therapeutic. current study,...
Temozolomide-resistant (TMZ-R) glioblastoma is very difficult to treat, and a novel approach overcome resistance needed.The efficacy of combination treatment STAT3 inhibitor, STX-0119, with rapamycin was investigated against our established TMZ-resistant U87 cell line.The growth-inhibitory effect the significant TMZ-R line (IC50: 78 μM for 30.5 11.3 two). Western blotting analysis demonstrated that inhibitory STX-0119 on S6 4E-BP1 activation through regulation YKL-40 expression occurred in...
<b>Objectives</b> Perifascial areolar tissue (PAT), a layer of loose connective on the deep fascias with rich vascular plexus, serves as vital cover over defects scarce vascularity. We report usefulness PAT nonvascularized alternative to flaps for reconstruction dural in skull base surgery and transsphenoidal while evaluating its effect control cerebrospinal fluid (CSF) leakage. <b>Design</b> A retrospective chart analysis was performed patients who had undergone repair defect during or...
We determined independent variables contributing to the development of late hydrocephalus after subarachnoid hemorrhage (SAH).A total 114 consecutive patients who underwent surgery for aneurysms within 72 h SAH were studied. Thirty-nine ventriculoperitoneal shunt (VPS) placement (14 30 days and 25 more than onset). Univariate multivariate analyses performed assess relationships among various placement.Three found be independently associated with VPS patients: (1) rate clearance; (2) duration...
Objective: The neuroendoscope is playing an increasing role in the diagnosis and treatment of several types lesions, particular ventricular system. Hydrocephalus associated with intraventricular hemorrhage (IVH) a good indication for neuroendoscopic surgery. We describe herein our experiences 17 cases IVH combined hydrocephalus treated using neuroendoscope.