A5042882487- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hematological disorders and diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Glioma Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Lung Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Infectious Diseases and Mycology
- Bone and Joint Diseases
- Glycosylation and Glycoproteins Research
- Parasitic Diseases Research and Treatment
- Peptidase Inhibition and Analysis
- Kawasaki Disease and Coronary Complications
- Viral-associated cancers and disorders
- Single-cell and spatial transcriptomics
- Fungal Infections and Studies
University of Tsukuba
1995-2024
University of Tsukuba Hospital
2023-2024
National Blood Transfusion Service
2021
Kameda Medical Center
2016-2020
Shizuoka Cancer Center
2012-2020
Zero to Three
2019
Seirei Social Welfare Community
2017
Tohoku University
2011
Toranomon Hospital
2002-2003
Oita Prefectural Hospital
2002
Summary This study aimed to clarify the comprehensive clinical, laboratory, pathological and imaging features of intravascular large B‐cell lymphoma (IVLBCL) using data on 42 IVLBCL patients diagnosed at our hospital over past 20 years. The majority were via random skin biopsy (29/42, 69·0%) followed by bone marrow alone (8/42, 19·0%). Characteristic included persistent fever (41/42, 97·6%), decreased performance status (≥2) (100%), hypoxaemia (32/40, 80·0%), impaired consciousness (19/42,...
Abstract The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal and endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our understanding lymphoma NHCs has been hampered by unexplained NHC heterogeneity, even normal human lymph nodes (LNs). Here we constructed a single-cell transcriptome atlas more than 100,000 collected from 27 samples, LNs various nodal lymphomas, it revealed 30 distinct subclusters, some that were previously...
High-grade gliomas including glioblastoma multiforme (GBM) are among the most malignant and aggressive of tumors, have a very poor prognosis despite temozolomide-based intensive treatment. Therefore, novel therapeutic approach to controlling recurrence is needed. In present study, we investigated effect activated dendritic cell (DC) (α-type-1 polarized DC)-based immunotherapy on high-grade glioma patients with HLA-A2 or A24 genotype. Nine recurrent 7 GBMs who fulfilled eligibility criteria...
Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells mutations promotes development of T follicular helper (TFH)-like tumor cells. Here, we investigated mechanism which TET2-mutant immune enable AITL using mouse models and human samples. Among 2 models, mice lacking Tet2 all blood (Mx-Cre × Tet2flox/flox transgenic mice) spontaneously developed for approximately up...
Abstract Peripheral T-cell lymphoma (PTCL) exhibits a diverse clinical spectrum, necessitating methods to categorize patients based on genomic abnormalities or tumor microenvironment (TME) profiles. We conducted an integrative multiomics study in 129 PTCL patients, performing whole-exome sequencing and identifying three genetic subtypes: C1, C2, C3. C2 was characterized by loss of suppressor genes chromosomal instability, while C1 C3 shared T follicular helper (TFH)-related alterations, with...
ABSTRACT In Japan, more than 10% of streptococcal toxic shock-like syndrome (TSLS) cases have been caused by Streptococcus pyogenes M3/T3 isolates since the first reported TSLS case in 1992. Most from or severe invasive infection during 1992 to 2001 and those noninvasive this period are indistinguishable pulsed-field gel electropherograms. The longest fragments these recent were 300 kb size, whereas recovered before 1973 260 size. These 260- 300-kb hybridized each other, suggesting...
Background/Aim: Glioblastoma multiforme (GBM) is an intractable tumor that has a very poor prognosis despite intensive treatment with temozolomide plus radiotherapy. Patients and Methods: Sixteen newly diagnosed patients high-grade gliomas were enrolled in phase II study of the α-type-1 DC vaccine. Briefly, DCs obtained from culture enriched monocytes presence cytokine cocktail, pulsed cocktail 5 synthetic peptides cryopreserved until injection into patients. Results: The amount IL-12...
Immune cells harboring somatic mutations reportedly infiltrate cancer tissues in patients with solid cancers and accompanying clonal hematopoiesis. Loss-of-function TET2 are frequently observed hematopoiesis cancers. Here, using a mouse lung model, we evaluated the activity of Tet2-deficient immune tumor tissues. Myeloid-specific Tet2 deficiency enhanced growth mice relative to that seen controls. Single-cell sequencing analysis infiltrating tumors showed relatively high expression...
Pulmonary resection along with multiple antimicrobial therapy has produced favorable outcomes at a few centers. However, little is known regarding the risk factors for long-term survival and microbiological recurrence after pulmonary nontuberculous mycobacterial disease (NTMPD). We evaluated of resection, including survival.This retrospective cohort study included 125 patients (median age, 60 years) NTMPD treated by two referral centers between January 1994 August 2015.Postoperative...
Purpose No study has analyzed a sizeable cohort that comprised solely peripheral T-cell lymphoma (PTCL) patients for the diagnostic and prognostic performance of 18 F-FDG PET/CT bone marrow (BM) involvement. This aimed to investigate utility identification BM involvement explore its relevance in with PTCL. Methods Eighty-three consecutive newly diagnosed PTCL were enrolled this retrospective study. The diagnosis was confirmed on basis positive histology or disappearance abnormalities...
MCP-1 and MIP-1alpha exhibit chemotactic activity toward macrophages/monocytes induce the production of inflammatory cytokines affecting granuloma formation. Up-regulated expression in affected organ sarcoidosis has been shown; however, relationship between their plasma levels clinical course this disease not determined. In present study we measured 26 patients with active by ELISA order to assess state disease. Most (21/26) had evidence extrathoracic addition pulmonary involvement....
Key Points Bone marrow abnormalities were detected in the AS of 196 consecutive symptomatic patients with MM. Medullary associated a poor prognosis, independent other clinical parameters.
Despite the development of novel Bruton tyrosine kinase inhibitor ibrutinib, mantle cell lymphoma (MCL) remains an incurable B-cell non-Hodgkin lymphoma. BMI-1 is required for self-renewal and maintenance MCL-initiating stem cells. Upregulation has been reported in MCL patients, especially those with refractory/relapsed disease. We studied effects a small-molecule selective BMI1 expression, PTC596, Eight lines patient-derived samples were exposed to PTC596. PTC596 induced mitochondrial...
Abstract T follicular helper (T FH ) cell lymphomas (TFHLs) are characterized by -like properties and accompanied substantial immune-cell infiltration into tumor tissues. Nevertheless, the comprehensive understanding of tumor-cell heterogeneity immune profiles TFHL remains elusive. To address this, we conducted single-cell transcriptomic analysis on 9 lymph node (LN) 16 peripheral blood (PB) samples from patients. Tumor cells were divided 5 distinct subclusters, with significant observed in...
OBJECTIVE. The prognostic value of medullary abnormalities in the appendicular skeleton (AS) patients with multiple myeloma (MM) has recently been suggested. However, functional evaluation these using PET/CT not investigated to date. This study aimed explore prevalence and relevance AS depicted by MM. MATERIALS AND METHODS. retrospective included 228 consecutive newly diagnosed, symptomatic MM who were treated novel agents. All underwent pretreatment 18F-FDG PET/CT. RESULTS. There 157...
Abstract Subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is a rare peripheral characterized by cutaneous lesions and immunologic manifestations. The five‐year survival rate of SPTCL has been reported to be over 80%, indicating favorable prognosis. Recent studies have uncovered recurrent germline variants in HAVCR2 , encoding an immunomodulator. In this study, we integrated whole‐exome sequencing data from 60 samples collected 36 patients, encompassing six patients our cohort 30...