A5101746296- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Cardiovascular and exercise physiology
- Cardiac Valve Diseases and Treatments
- Pelvic floor disorders treatments
- Cardiac Health and Mental Health
- Congenital Heart Disease Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Structural Anomalies and Repair
- Infectious Diseases and Mycology
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Pleural and Pulmonary Diseases
- Congenital Diaphragmatic Hernia Studies
- Nutrition and Health in Aging
- Anorectal Disease Treatments and Outcomes
- COVID-19 Clinical Research Studies
- Cardiovascular Effects of Exercise
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- Infective Endocarditis Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
Saitama Municipal Hospital
2021-2025
City Hospital
2025
University of Yamanashi
2010-2024
Tokyo Medical University
2008-2024
RIKEN Center for Integrative Medical Sciences
2024
Keio University
2014-2023
National Hospital Organization
2016-2023
Japanese Red Cross Nagoya Daiichi Hospital
2019-2023
Kasumigaura Medical Center
2016-2023
Japanese Red Cross Nagoya Daini Hospital
2018-2021
Abstract Aims The objective of the study was to evaluate whether geriatric nutritional risk index (GNRI) at discharge may be helpful in predicting long‐term prognosis patients hospitalized with heart failure (HF) preserved ejection fraction (HFpEF, left ventricular ≥50%), a common HF phenotype elderly. Methods and results Overall, 110 elderly HFpEF (≥65 years) from Ibaraki Cardiovascular Assessment Study‐HF ( n = 838) were enrolled. mean age 78.5 ± 7.2 years, male accounted for 53.6% 59)....
In 24 median nerves from 12 healthy subjects, antidromic digital sensory potentials progressively diminished in size, averaging 40.4,37.0, 30.7, and 23.9 μV × msec with stimulation at the palm, wrist, elbow, axilla, respectively. contrast, compound muscle action changed minimally, measuring 19.4, 19.8,19.0, 18.2 mV msec, Similar studies of ulnar radial showed identical trends. Physiologic temporal dispersion can mimic conduction block by summating peaks opposite polarity generated fast-...
Introduction: Increased abdominal visceral fat has been shown to be a cardiovascular risk factor. Preliminary studies indicate that pericardiac (PF) may provide similar information. We aimed develop new software (QFAT) for automatic quantitation of PF from noncontrast cardiac CT and compare measures other factors. Methods: QFAT accepts user-defined range transverse slices, automatically segments the heart, determines volume (PFV) as contiguous pericardial voxels. PFV normalized defines ratio...
In multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [AMK]) is recommended for difficult-to-treat non-tuberculous mycobacterial (NTM) lung diseases. We aimed to evaluate the efficacy, safety, and feasibility of inhaled AMK therapy in patients with NTM diseases a retrospective chart review. The study population consisted who received combination therapy, at Keio University Hospital (Tokyo, Japan), from January 2014 through May 2016. A total 26 cases, consisting 23...
Empiric therapy of pneumonia is currently based on the site acquisition (community or hospital), but could be chosen, risk factors for multidrug-resistant (MDR) pathogens, independent acquisition. We prospectively applied a therapeutic algorithm MDR risks, in multicenter cohort study 1089 patients with 656 community-acquired (CAP), 238 healthcare-associated (HCAP), 140 hospital-acquired (HAP), 55 ventilator-associated (VAP). Approximately 83% were treated according to algorithm, 4.3%...
Coronary artery calcification (CAC) detected through chest computed tomography (CT) strongly predicts cardiovascular events in asymptomatic individuals undergoing primary prevention. Few studies with limited sample sizes have investigated the predictive value of CAC for complications COVID-19. This study examined impact on using a large-scale COVID-19 database. multicenter retrospective cohort used data from Japan Task Force After exclusion based missing information, 1,109 patients were...
ABSTRACT Background Chest computed tomography (CT) is a valuable tool for diagnosing and predicting the severity of coronavirus disease 2019 (COVID‐19) assessing extrapulmonary organs. Reduced muscle mass visceral fat accumulation are important features body composition phenotype in which obesity loss coexist, but their relationship with COVID‐19 outcomes remains unclear. In this study, we aimed to investigate association between erector spinae (ESM) epicardial adipose tissue (EAT) ratio...
Although vasospastic angina usually responds well to treatment with calcium antagonists and/or nitrates, there have been anecdotal case reports of refractory resistant intensive high doses and nitrates.Four patients angina, which was were completely controlled after administration corticosteroids. none the 4 showed eosinophilia, all had bronchial asthma or chronic thyroiditis, in 2 cases, activity corresponded that asthma.These findings suggest these patients, coronary spasm may induced by...
Mycobacterium avium complex (MAC) lung diseases generally cause chronic disease in immunocompetent hosts. Although a few studies have examined health-related quality of life (HRQL) patients with MAC disease, there been no large studies. This study aimed to evaluate HRQL and its correlation clinical outcomes disease.A cross-sectional was conducted at Keio University Hospital investigate the factors associated pulmonary nontuberculous mycobacterial diseases. were diagnosed according 2007...
In the Berlin definition, acute respiratory distress syndrome (ARDS) is stratified into three stages according to oxygenation severity at onset. The relevance between ARDS and prognosis varies among published reports has not been verified, especially in Asian patients. this study, we examined associations definition criteria clinical parameters, including high-resolution computed tomography (HRCT) scores of fibroproliferative changes lungs. One hundred fifty-three patients (45 females; mean...
Nontuberculous mycobacteria (NTM) are environmental that can cause a chronic progressive lung disease. Although epidemiological data indicate potential genetic predisposition, its nature remains unclear.We aimed to identify host susceptibility loci for Mycobacterium avium complex (MAC), the most common NTM pathogen.This genome-wide association study (GWAS) was conducted in Japanese patients with pulmonary MAC and healthy controls, followed by genotyping of candidate single-nucleotide...
Background: Recently, the number of Helicobacter pylori isolates showing antibiotic resistance has been increasing. Rifabutin (RFB) is one possible candidates for H. eradication. In present study, RFB minimum inhibitory concentrations (MICs) and resistance-determining genes to (rpoB) were examined clarify relationship between drug MICs, rpoB mutations, past history rifampicin (RFP) treatment. Methods: The MICs mutations 48 strains with failure eradication in University Hospital 46 isolated...
Pulmonary resection along with multiple antimicrobial therapy has produced favorable outcomes at a few centers. However, little is known regarding the risk factors for long-term survival and microbiological recurrence after pulmonary nontuberculous mycobacterial disease (NTMPD). We evaluated of resection, including survival.This retrospective cohort study included 125 patients (median age, 60 years) NTMPD treated by two referral centers between January 1994 August 2015.Postoperative...
Macrolides are used to treat various inflammatory diseases owing their immunomodulatory properties; however, little is known about precise mechanism of action. In this study, we investigated the functional significance expansion myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response macrolide antibiotic clarithromycin (CAM) mouse models shock and post-influenza pneumococcal pneumonia as well humans. Intraperitoneal administration CAM markedly expanded splenic lung...
Multiple prolonged symptoms are observed in patients who recover from an acute COVID-19 infection, which is defined as long COVID. General fatigue frequently with COVID during and post-acute phases. This study aimed to identify the specific risk factors for general
Controlling nutritional status (CONUT) uses 2 biochemical parameters (serum albumin and cholesterol level), 1 immune parameter (total lymphocyte count) to assess status. This study examined if CONUT could predict the short-term prognosis of heart failure (HF) patients.
In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact PA MACLD patients. cross-sectional was conducted using Registry Prospective Cohort Study including The 36-item Short-Form health survey (SF-36) St. George’s Respiratory Questionnaire (SGRQ)...