A5078105320- Mycobacterium research and diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Pleural and Pulmonary Diseases
- Influenza Virus Research Studies
- Diabetes and associated disorders
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- interferon and immune responses
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Infectious Diseases and Mycology
- Drug-Induced Adverse Reactions
- Tracheal and airway disorders
- Helicobacter pylori-related gastroenterology studies
- Dysphagia Assessment and Management
- Single-cell and spatial transcriptomics
- COVID-19 and Mental Health
- Lung Cancer Research Studies
Tachikawa Hospital
2018-2025
Keio University
2012-2024
Tokyo Medical Center
2015-2018
National Hospital Organization
2015-2018
Pulmonary Associates
2010-2015
Background Multiple prolonged symptoms observed in patients who recovered from COVID-19 are defined as long COVID. Although diverse phenotypic combinations possible, they remain unclear. This study aimed to perform a cluster analysis of COVID Japan and clarify the association between its characteristics background factors quality life (QOL). Methods multicentre prospective cohort collected various QOL after January 2020 February 2021. included 935 aged ≥18 years with at 26 participating...
In multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [AMK]) is recommended for difficult-to-treat non-tuberculous mycobacterial (NTM) lung diseases. We aimed to evaluate the efficacy, safety, and feasibility of inhaled AMK therapy in patients with NTM diseases a retrospective chart review. The study population consisted who received combination therapy, at Keio University Hospital (Tokyo, Japan), from January 2014 through May 2016. A total 26 cases, consisting 23...
We describe two patients who experienced serious multiple immune‐related adverse events (irAEs), treatment interruption, and steroid administration. Despite these challenges, they achieved a remarkable antitumor effect beyond the expected. Various carcinomas demonstrated possible correlation between of immune checkpoint inhibitors intensity irAEs, but few studies report on malignant pleural mesothelioma (MPM). Our cases exhibited much stronger irAEs than usual. These still complete response...
Although arachidonic acid cascade has been shown to be involved in sepsis, little is known about the role of PGD(2) and its newly found receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), septic response. Severe sepsis associated with failure neutrophil migration. To investigate whether CRTH2 influences recruitment lethality during was induced by cecal ligation puncture (CLP) surgery mice. knockout (CRTH2(-/-)) mice were highly resistant CLP-induced which...
Increasing evidence suggests that mesenchymal stem cells (MSCs) play anti-inflammatory roles during innate immune responses. However, little is known about the effect of MSCs or their secretions on ligand response Toll-like receptor (TLR) 7 and TLR8, receptors recognize viral single-stranded RNA (ssRNA). Macrophages a critical role in to ssRNA virus infection; therefore, we investigated MSC-conditioned medium cytokine expression macrophages following stimulation with TLR7/8 ligands. After...
Mycobacterium avium complex (MAC) lung diseases generally cause chronic disease in immunocompetent hosts. Although a few studies have examined health-related quality of life (HRQL) patients with MAC disease, there been no large studies. This study aimed to evaluate HRQL and its correlation clinical outcomes disease.A cross-sectional was conducted at Keio University Hospital investigate the factors associated pulmonary nontuberculous mycobacterial diseases. were diagnosed according 2007...
ABSTRACT Background and objective: Combined pulmonary fibrosis emphysema (CPFE) is characterized by upper lobe together with lower fibrosis. The aim of this study was to examine whether cytokine levels in the alveolar space are associated emphysematous changes superimposed on Methods: Consecutive patients ( n = 102), diagnosed were retrospectively evaluated. Cytokine differential cell counts bronchoalveolar lavage (BAL) fluid, function, computed tomography (CT) scores serum markers compared...
Prognostic understanding in advanced cancer patients and their caregivers may have an impact on the delivery of effective care. The aims this study were to explore prognostic at diagnosis both with lung investigate correlates understanding.A total 193 newly diagnosed 167 enrolled 16 hospitals Japan. We assessed perceptions prognosis goals therapy examined associations sociodemographic characteristics, clinical status, quality life, mood symptoms, status disclosure information by treating...
Abstract Background and objective Osteoporosis is an important systemic comorbidity of chronic obstructive pulmonary disease ( COPD ). However, neither its mechanisms nor risk factors have been fully elucidated. With regard to genetic factors, low‐density lipoprotein receptor‐related protein 5 LRP ) A 1330 V known be associated with osteoporosis in the general population, but influence this polymorphism unknown. The aim study was investigate potential ‐related bone loss fracture. Methods...
In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact PA MACLD patients. cross-sectional was conducted using Registry Prospective Cohort Study including The 36-item Short-Form health survey (SF-36) St. George’s Respiratory Questionnaire (SGRQ)...
The clinical features of PCP differ according to the factors responsible for predisposing immunosuppression. Although diagnosis often requires BAL, profiles inflammatory mediators in BAL fluid are not thoroughly documented. aim current study was characterize during patients with underlying autoimmune diseases, malignancies, or AIDS. medical records 14 10 and 8 AIDS, all whom had been diagnosed by microscopic examination fluid, were reviewed. concentrations TNF-alpha, MCP-1, HMGB1, IL-8,...
Pneumonia is the fourth-leading cause of death globally, and Streptococcus pneumoniae most important causative pathogen. Because incidence pneumococcal diseases likely to increase with aging society, we should determine an optimal strategy for vaccination. While consensus indicates that 23-valent polysaccharide vaccine prevents invasive (IPD), its effects on community-acquired pneumonia (CAP) remain controversial. Recently, a 13-valent conjugate (PCV13) was released. The latest clinical...
Intimal sarcoma is a rare disease with poor prognosis. We herein report the case of 71-year-old man intimal pulmonary artery treated pazopanib. The tumor showed regression after 1 month treatment. Hand-foot syndrome led to cessation pazopanib, which triggered flare. Pazopanib should be considered in patients that unresectable or recurrent surgery cytotoxic chemotherapy. must careful about drug cessation, as it can lead
Introduction The rapid spread of COVID-19 posed a global burden. Substantial number people died the disease in acute phase infection. In addition, significant proportion patients have been reported to suffer from post-acute symptoms, sequelae COVID-19, which may negatively influence quality daily living and/or socioeconomic circumstances patients. However, no previous study has comprehensively and objectively assessed life by using existing international scales. Further, evidence...
Little is known about the clinical characteristics and health-related quality of life (HQOL) elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease.To evaluate HQOL using 36-Item Short-Form Health Survey St George's Respiratory Questionnaire (SGRQ) to investigate predictors changes among pMAC disease.This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 July 2015 included 84 disease aged 75 years who had completed...
Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine association six-minute walk test (6MWT) parameters with pulmonary function and health-related quality life (HRQL) in patients pMAC This cross-sectional included adult conducted at Keio University Hospital. We investigated relationship 6MWT clinical parameters, including function, HRQL, which assessed using 36-Item Short Form Health Survey (SF-36) St....
Mycobacterium lentiflavum is a slow-growing non-tuberculous that often associated with an immunocompromised state and cervical lymphadenitis in young children. However, little known about the clinical importance of pulmonary infection M. adults.The medical records all adults who met diagnostic criteria disease at Keio University Hospital Fukujuji from 2001 to 2015 were reviewed. In addition, PubMed database was searched identify further reported cases non-HIV adults.Five identified search 11...
Background There is no proven management for mild cases of Mycobacterium avium complex (MAC) pulmonary disease, who do not immediately receive treatment and are managed with observation alone, because its long term-natural course, factors predictive deterioration, the effect treating disease remain unclear. Thus, we sought to investigate natural course MAC disease. Methods We conducted a multicenter retrospective study. Sixty-five patients in whom was withheld at least 6 months after...
An open-labeled randomized study was conducted to compare the immunogenicity and safety of polysaccharide (PPV23) or protein-conjugated pneumococcal vaccine (PCV7) among elderly aged 80 years older. A total 105 nursing home residents were enrolled in this study. We analyzed geometric mean concentration (GMC) serotype-specific immunoglobulin G (IgG) titer (GMT) opsonization index (OI) for serotypes 4, 6B, 9V, 14, 18C, 19F, 23F. The GMCs IgG GMTs OI significantly increased one month after...
背景.ドライバー遺伝子変異/転座陰性のIV期非小細胞肺癌における免疫チェックポイント阻害薬(immune checkpoint inhibitor:ICI)の有効性が知られている一方で様々な免疫関連有害事象(immune-related adverse events:irAEs)が報告されており,その一つに硬化性胆管炎が存在する.しかし報告は少なく,その臨床経過や治療については明らかではない.症例.当院で硬化性胆管炎を発症した3例の臨床経過について検討した.3例はICI投与中ないし投与後に胆道系酵素優位の肝機能障害を認めた.Magnetic resonance cholangiopancreatography(MRCP)で肝内胆管に病変が限局していた1例はステロイドにより改善したが,肝内胆管及び肝外胆管に病変を認めた2例はステロイド反応性が良好と不良に分かれた.結論.irAE硬化性胆管炎のステロイド反応性の予測因子について,当院の3例の臨床経過に論文的考察を加えて検討した.肝内胆管に病変が限局する場合はステロイド反応性が良好である可能性が示唆された.