A5086665187- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Smoking Behavior and Cessation
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Obesity, Physical Activity, Diet
- COVID-19 and healthcare impacts
- Respiratory and Cough-Related Research
- Lung Cancer Treatments and Mutations
- Behavioral Health and Interventions
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Mobile Health and mHealth Applications
- Antifungal resistance and susceptibility
- COVID-19 and Mental Health
- Pediatric health and respiratory diseases
- Single-cell and spatial transcriptomics
- Allergic Rhinitis and Sensitization
- Infectious Diseases and Mycology
- Thermal Regulation in Medicine
- Fibromyalgia and Chronic Fatigue Syndrome Research
Saitama Municipal Hospital
2017-2025
City Hospital
2019-2025
Keio University
2008-2024
Pulmonary Associates
2021
Saitama Medical University
2017
The University of Tokyo
2015
Miyagi Prefectural Hospital Organization
2010
Brigham and Women's Hospital
2004
Harvard University
2004
United States Army
2004
Evidence of the long-term efficacy digital therapies for smoking cessation that include a smartphone application (app) is limited. In this multi-center randomized controlled trial, we tested novel therapy cessation: "CureApp Smoking Cessation (CASC)" system, including CASC app, web-based patient management PC software primary physicians, and mobile exhaled carbon monoxide (CO) checker. A total 584 participants with nicotine dependence were recruited from October 2017 to January 2018,...
To evaluate the ability of high-resolution computed tomography (HRCT) to detect longitudinal changes in structural abnormalities caused by smoking, HRCT and pulmonary function tests were used examine nonsmokers, current smokers, past smokers annually for 5 yr. Inspiratory was taken upper, middle, lower lung fields, while expiratory images obtained upper fields only. We estimated three quantitative CT parameters including MLD (mean value), HIST (CT value with most frequent appearance), %LAA...
Besides lowering cholesterol, statins exert multiple effects, such as anti-inflammatory activity and improvement of endothelial cell function. We examined whether simvastatin (SS) protects against the development elastase-induced pulmonary emphysema in mice by using mean linear intercepts alveoli (Lm) a morphometric parameter emphysema. After injection intratracheal elastase on day 0, C57BL/6 were treated daily with SS (SS+ group) or PBS (SS- for 2 wk. A 21% decrease Lm 7 was observed SS+...
Mobile apps have been considered to provide active and continuous support for smoking cessation. However, it is yet be known whether a cessation smartphone app improves long-term abstinence rates in nicotine-dependent patients.This study aimed evaluate the effect of novel app, CureApp Smoking Cessation (CASC), patients with nicotine dependence.In this prospective, interventional, multicenter, single-arm study, we provided CASC all participants, who used daily 24 weeks. The includes features...
Multiple prolonged symptoms are observed in patients who recover from an acute COVID-19 infection, which is defined as long COVID. General fatigue frequently with COVID during and post-acute phases. This study aimed to identify the specific risk factors for general
Coronary artery calcification (CAC) detected through chest computed tomography (CT) strongly predicts cardiovascular events in asymptomatic individuals undergoing primary prevention. Few studies with limited sample sizes have investigated the predictive value of CAC for complications COVID-19. This study examined impact on using a large-scale COVID-19 database. multicenter retrospective cohort used data from Japan Task Force After exclusion based missing information, 1,109 patients were...
ABSTRACT Background Chest computed tomography (CT) is a valuable tool for diagnosing and predicting the severity of coronavirus disease 2019 (COVID‐19) assessing extrapulmonary organs. Reduced muscle mass visceral fat accumulation are important features body composition phenotype in which obesity loss coexist, but their relationship with COVID‐19 outcomes remains unclear. In this study, we aimed to investigate association between erector spinae (ESM) epicardial adipose tissue (EAT) ratio...
Allergen exposure induces the airway epithelium to produce chemoattractants, proallergic interleukins, matrix-modifying proteins, and proteins that influence growth activation state of structural cells. These in turn, contribute influx inflammatory cells changes structure characterize asthmatic airway. To use response allergen identify genes not previously associated with allergic responses, we compared gene expression cytokeratin-positive before after segmental challenge. After challenge...
Purpose . This study aimed to examine whether plasma levels of cathepsin S or its inhibitor, cystatin C, may serve as biomarkers for COPD. Patients and Methods We measured anthropometrics performed pulmonary function tests chest CT scans on 94 patients with COPD 31 subjects productive cough but no airflow obstruction (“at risk”; AR). In these in 52 healthy nonsmokers (NS) 66 smokers (HS) we concentrations C using an ELISA. Data were analyzed simple logistic regression receiver operating...
ABSTRACT Background and Objective Administration of oral corticosteroids and/or azole antifungals for 4–6 months remains the standard treatment allergic bronchopulmonary aspergillosis (ABPA). This study investigated clinical characteristics patients with difficult‐to‐treat ABPA who failed to achieve remission within 6 months. Methods Among participants a nationwide survey conducted in Japan 2020, treatment‐naïve satisfied Asano's criteria were enrolled this study. Clinical was defined as...
Collagenous colitis is a distinct clinicopathologic entity characterized by chronic watery diarrhea and, histologically, the subepithelial deposition of collagen [1] [2]. Some luminal antigens, including nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs), particularly lansoprazole, are thought to contribute development collagenous colitis. On endoscopy, usually shows no or minimal nonspecific abnormalities. However, recent report showed that "linear mucosal...
Efferocytosis is believed to be a key regulator for lung inflammation in chronic obstructive pulmonary disease. In this study we pharmacologically inhibited efferocytosis with annexin V and attempted determine its impact on the progression of emphysema mouse. We first demonstrated vitro vivo experiments using V, an inhibitor phosphatidylserine-mediated efferocytosis. then porcine pancreatic elastase (PPE)-treated mice. PPE-treated mice were instilled intranasally starting from day 8 until...
Introduction The rapid spread of COVID-19 posed a global burden. Substantial number people died the disease in acute phase infection. In addition, significant proportion patients have been reported to suffer from post-acute symptoms, sequelae COVID-19, which may negatively influence quality daily living and/or socioeconomic circumstances patients. However, no previous study has comprehensively and objectively assessed life by using existing international scales. Further, evidence...
Chronic eosinophilic pneumonia (CEP) is characterized by chronic or recurrent pulmonary infiltrates with eosinophils, but the precise mechanism of eosinophil accumulation has not been fully elucidated. Eotaxin one CC chemokines that selectively recruits eosinophils and contributes to pathogenesis allergic airway diseases including asthma, its roles in CEP have The authors measured concentrations eotaxin other chemokines, monocyte chemoattractant protein-1 (MCP-1), regulated on activation,...
Smoking cessation treatment programs have been widely available for patients with nicotine dependence. Despite intensive programs, the continuous abstinence rate (CAR) from weeks 9-12 is still about 50%. Recently, a smartphone app emerged as novel tool therapeutic interventions, including In this study, we developed "CureApp Cessation" (CASC), which consists of and Web-based patient management software doctors mobile carbon monoxide (CO) checking device to improve efficacy smoking...
Rationale: The clinical features and prognosis of nontuberculous mycobacterial (NTM) pleuritis pleural effusion combined with NTM lung disease remain unclear. Objectives: To investigate the pleuritis. Methods: This retrospective observational study included patients from January 2001 to June 2018 across eight hospitals in Japan. was defined by a positive culture samples. We matched Mycobacterium avium complex (MAC) (MAC-LD) without sex age obtain comparative data investigated association...