A5005296918- Reproductive System and Pregnancy
- CAR-T cell therapy research
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Immune Cell Function and Interaction
- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Peptidase Inhibition and Analysis
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Semiconductor materials and devices
- Monoclonal and Polyclonal Antibodies Research
- Advancements in Semiconductor Devices and Circuit Design
- Viral Infectious Diseases and Gene Expression in Insects
- Cytokine Signaling Pathways and Interactions
- Silicon Carbide Semiconductor Technologies
- Angiogenesis and VEGF in Cancer
- Circadian rhythm and melatonin
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cervical Cancer and HPV Research
- Maternal and fetal healthcare
Kanazawa University
2016-2025
Azabu University
2025
Kyoto University
2007-2024
Meiji University of Integrative Medicine
2024
Ehime University
2010-2023
Kanazawa Medical University
2020-2023
Mie University
2019-2023
Shinshu University
2021
Toyota Motor Corporation (Japan)
2012-2020
National Center for Infectious Diseases
2009-2017
gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic and cardiotrophin 1. To investigate physiological roles of to examine pathological consequences lack gp130, mice deficient for have been prepared. Embryos homozygous the mutation progressively die between 12.5 days postcoitum term. On 16.5 later, they show hypoplastic ventricular myocardium without septal trabecular defect. The...
Mix and match: A tungsten–tin mixed hydroxide (W–Sn hydroxide), prepared by the simple coprecipitation method, acts as a reusable heterogeneous catalyst for dehydration of various aldoximes to corresponding nitriles (see scheme, top). Furthermore, W–Sn could be applied direct one-pot synthesis from hydroxylamine aldehydes bottom).
Dehydration/Rehydration in Water: Supported rhodium hydroxide (Rh(OH)x/Al2O3) is an effective heterogeneous catalyst for the synthesis of primary amides from aldoximes and aldehydes water a reaction that entirely free hazardous carcinogenic organic solvents (see scheme).
The CD23 antigen, a low-affinity receptor for IgE (Fc epsilon RII), is type II membrane-bound glycoprotein expressed on various cells, particularly mature B cells. A number of functions have been ascribed to CD23, including specific regulation production, IgE-mediated cytotoxicity and release mediators, IgE-dependent antigen focusing, promotion B-cell growth, prevention germinal center cells from apoptosis, proliferation myeloid precursors, maturation early thymocytes. It not clear whether...
The density, shape and structure of in-grown stacking faults in 4H–SiC (0001) epitaxial layers have been characterized by cathodeluminescence, photoluminescence high-resolution transmission electron microscopy. These analyses indicate that are 8H structure, generated mostly near the epilayer/substrate interface during chemical vapor deposition. impact on performance Schottky barrier diodes has investigated. It is revealed cause lowering height as well decrease breakdown voltage.
Journal Article Immunohistochemical localization of androgen receptor in the human ovary throughout menstrual cycle relation to oestrogen and progesterone expression Get access Kiyoshige Horie, Horie 1 1To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenji Takakura, Takakura Hiroshi Fujiwara, Fujiwara Suginami, Suginami Shutsung Liao, Liao 2Ben May Institute, University ChicagoIL, USA Takahide Mori Human Reproduction,...
BACKGROUND: There are few effective approaches to infertile patients with repeated failure in IVF–embryo transfer therapy. Since recent evidence suggests that some populations of maternal immune cells positively support embryo implantation, we have developed a new approach using peripheral blood mononuclear (PBMCs). METHODS: Patients who had not experienced successful pregnancy despite four or more sessions were enrolled this study (n = 35, 35 cycles). PBMCs obtained from on the day oocyte...
Human luteal cells have been reported to express human leukocyte antigen-DR and lymphocyte functional antigen-3 on the cell surface, suggesting physiological interaction between T-lymphocytes through menstrual cycle into early pregnancy. To elucidate role of peripheral lymphocytes corpus luteum differentiation, effect blood mononuclear (PBMC) steroidogenesis by was investigated. The production Th-2 cytokines such as interleukin (IL)-4 IL-10 co-cultured also examined, effects these...
To elucidate the pathophysiology of pulmonary fibrosis, we investigated involvement p38 mitogen-activated protein kinase (MAPK), which is one major signal transduction pathways proinflammatory cytokines, in a murine model bleomycin-induced lung fibrosis. MAPK and its substrate, activating transcription factor (ATF)-2, bronchoalveolar lavage fluid cells were phosphorylated by intratracheal exposure bleomycin, phosphorylation ATF-2 was inhibited subcutaneous administration specific inhibitor...
At the human feto-maternal interface, trophoblasts differentiate towards extravillous (EVTs) and form cell column. EVTs acquire invasive activity in distal part of column begin to migrate into maternal tissue. We previously reported that dipeptidyl peptidase IV(DPPIV) is expressed on proximal involved inhibition their migration. Because DPPIV has been shown degrade several chemokines, we examined possible roles chemokines EVT Immunohistochemistry demonstrated C-C chemokine receptor 1 (CCR1)...
Abstract The primary granule proteins (PGP) of myeloid cells are a source multiple antigens with immunotherapeutic potential for leukemias. Therefore, we developed method to induce T-cell responses PGP protein sequences. We found that gene-transfected antigen-presenting efficiently expand functionally competent PGP-specific CD4 and CD8 T cells. system was optimized using autologous CD40-activated B (CD40-B) transfected cytomegalovirus pp65-encoding expression vector. To generate...
In health, pulmonary alveoli are maintained free of inflammatory responses to inhaled foreign antigens. The specific role alveolar macrophages (AM) in modulating the local cellular immune response antigens is controversial. Immunoregulatory function and properties AM blood monocytes (MN) were compared. obtained by bronchoalveolar lavage healthy volunteers, MN adherence peripheral mononuclear cells plastic. These accessory added increasing ratios a responder population rendered rigorously...
Abstract We examined stimulation of monocyte (MN) release interleukin 1 (IL 1) by soluble microbial products. MN from tuberculin skin test nonreactive donors incubated with PPD (100 micrograms/ml) released IL activity 80.5 +/- 33.9 U/ml (mean SD, n = 6), similar to that induced optimal concentrations LPS (76.4 U/ml). OKT3-reactive cells were not required for this process. PPD-stimulated did appear be due endotoxin contamination, as contained 0.01% endotoxin, 2) in (0.1 produced 19.5 13.9...
Interleukin-1 (IL-1) production by blood monocytes and blastogenesis produced tuberculin purified protein derivative (PPD) in T lymphocytes were examined patients with pulmonary tuberculosis. Monocytes isolated from mononuclear cells plastic adherence, IL−1 activity was determined the mouse thymocyte proliferation assay. tuberculosis significantly higher activities of than did those healthy reactors when stimulated lipopolysaccharide (LPS) (patients, 56.1 ± 20.0 U/ml; control subjects, 7.3...