A5102837519- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Cardiovascular Function and Risk Factors
- Ovarian cancer diagnosis and treatment
- Toxic Organic Pollutants Impact
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Cardiac Imaging and Diagnostics
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Animal testing and alternatives
- Per- and polyfluoroalkyl substances research
- Chemical Synthesis and Characterization
- Cardiomyopathy and Myosin Studies
- Neonatal Respiratory Health Research
- Endometrial and Cervical Cancer Treatments
- Reproductive Biology and Fertility
- Hair Growth and Disorders
- Congenital Anomalies and Fetal Surgery
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- Veterinary Pharmacology and Anesthesia
- Aluminum toxicity and tolerance in plants and animals
- Inorganic Chemistry and Materials
State Research Institute for Chemistry and Technology of Organoelement Compounds
2003-2021
Obihiro University of Agriculture and Veterinary Medicine
2019
Hiroshima University
2018
Chiba University
2011-2015
Osaka University
2014
Adult Congenital Heart Association
2014
Osaka City University
2014
Shimane University
2014
Kyoto University
1988-2012
Chemicals Evaluation and Research Institute
2012
BACKGROUND: There are few effective approaches to infertile patients with repeated failure in IVF–embryo transfer therapy. Since recent evidence suggests that some populations of maternal immune cells positively support embryo implantation, we have developed a new approach using peripheral blood mononuclear (PBMCs). METHODS: Patients who had not experienced successful pregnancy despite four or more sessions were enrolled this study (n = 35, 35 cycles). PBMCs obtained from on the day oocyte...
Human luteal cells have been reported to express human leukocyte antigen-DR and lymphocyte functional antigen-3 on the cell surface, suggesting physiological interaction between T-lymphocytes through menstrual cycle into early pregnancy. To elucidate role of peripheral lymphocytes corpus luteum differentiation, effect blood mononuclear (PBMC) steroidogenesis by was investigated. The production Th-2 cytokines such as interleukin (IL)-4 IL-10 co-cultured also examined, effects these...
Mast cells (MCs) are widely distributed in most human tissues. Those that contain only tryptase designated as T-MCs, while those also chymase referred to TC-MCs. This study uses immunohistochemical staining for and assess the distribution heterogeneity of these two types MCs uterus. The greatest number was found inner (i.e. luminal) half myometrium, with this area containing approximately equal proportions T-MCs There were fewer outer myometrium cervix, but proportion TC-MCs both areas...
Perfluoroalkyl carboxylic acids (PFCAs) are a series of environmental contaminants that have received attention because their possible adverse effects on wildlife and human health. Although many toxicological studies been performed perfluorooctanoic acid with carbon chain length C8, available toxicity data PFCAs longer chains still insufficient to evaluate hazard. A combined repeated dose reproductive/developmental screening study for perfluorododecanoic (PFDoA; C12) was conducted in...
Recently we reported that CD9 is involved in the invasion of a trophoblast-like choriocarcinoma cell line, BeWo, probably through regulation integrin functions. Integrins have also been to be expressed human endometrium and it has suggested they play important roles blastocyst implantation. This study used immunohistochemistry investigate expression during menstrual cycle. was found intensely on surface glandular epithelium throughout cycle without any apparent differences staining...
A two-generation reproductive toxicity study was performed to evaluate the effects of diethyl phthalate on parental performance, including features endocrine system and development growth offspring at dietary dose levels 0, 600, 3000 15000 ppm. In F0 F1 parents, no treatment-related adverse were observed in clinical findings, body weights, food consumption, parameters, gross or histopathological findings any treated group. Increased liver weights enhanced activities metabolic enzymes males...
Background: Quantitative assessment of left ventricular ejection fraction (LVEF) is technically difficult in patients with poor image quality (IQ). Mitral annulus velocity assessed by pulsed tissue Doppler imaging (TDI) and mitral motion M‐mode echocardiography has been shown to correlate LVEF. Furthermore, sites are easy identify even IQ. The purpose this study was determine whether these methods useful for estimating LVEF Methods: One hundred ten underwent TDI simultaneously. were obtained...
Low-dose oral contraceptives (OC) have been reported to control primary dysmenorrhea. Furthermore, a close relationship between dysmenorrhea and uterine contractions has visualized with magnetic resonance imaging (MRI). This study aimed use cine MR demonstrate the effects of OC on myometrial contractility during menstruation associate findings dysmenorrhea.MR studies were obtained 21 healthy female volunteers (22-47 years old) taking OC, 20 women (24-39 not OC. Cine- static images 1.5 T...
Maternal food restriction is known to cause developmental hypertension in offspring. We have previously shown that maternal high-protein diet can reverse fetal programming of and branched-chain amino acid (BCAA) concentrations plasma were increased by intake. Then, we hypothesized isocaloric supplementation with BCAA a the adverse outcome. Pregnant rats divided into four groups at 7.5 days postcoitum: normally nourished (NN) 70% undernourished (UN) without (NN–standard (SD), NN–BCAA, UN–SD...
Male and female rats were given perfluorooctadecanoic acid (PFOdA) by gavage at 40, 200 or 1,000 mg/kg/day, each was mated with a male in the same dose group after 14-day administration. Males dosed for 42 days females throughout gestation period until day 5 of lactation. One mg/kg/day euthanized on 18 due to moribund condition; however, no other treatment-related clinical signs toxicity observed. Body weights fell from 28 through administration males lactation females. Red blood cell count,...
Abstract Historical control data on rodent developmental toxicity studies, performed between 1994 and 2010, were obtained from 19 laboratories in J apan, including 10 pharmaceutical chemical companies nine contract research organizations. Rats, mice, hamsters used for studies. Data included maternal reproductive findings at terminal cesarean sections fetal the spontaneous incidences of external, visceral, skeletal anomalies. No noticeable differences observed laboratories. Inter‐laboratory...
Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies nine contract in Japan. In this paper, incorporated a laboratory if the information was based 10 studies or more. Japanese White rabbits New Zealand used for studies. The included maternal reproductive findings at terminal cesarean sections fetal spontaneous incidences of morphological alterations. No...
Perfluoroalkyl carboxylic acids (PFCAs) are global environmental contaminants that the cause of concern due to their possible effects on wildlife and human health. Since few studies have investigated toxicity long-chain PFCAs, we performed combined repeated dose with reproduction/developmental screening tests. We previously examined perfluoroundecanoic acid (C11), perfluorododecanoic (C12), perfluorooctadecanoic (C18). herein reported our results for perfluorotetradecanoic (PFTeDA; C14)...