A5014009386- Food composition and properties
- Diet and metabolism studies
- Microbial Metabolites in Food Biotechnology
- Digestive system and related health
- Nutritional Studies and Diet
- Protein Hydrolysis and Bioactive Peptides
- Diet, Metabolism, and Disease
- Infant Nutrition and Health
- Gut microbiota and health
- Polysaccharides Composition and Applications
- Bone health and osteoporosis research
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Phytase and its Applications
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Probiotics and Fermented Foods
- Polysaccharides and Plant Cell Walls
- Regulation of Appetite and Obesity
- Bone and Dental Protein Studies
- Birth, Development, and Health
- Phytoestrogen effects and research
- Nutrition, Genetics, and Disease
- Food Quality and Safety Studies
Otsuma Women's University
2015-2024
Showa Ika Kogyo (Japan)
2014
New York University Press
2011
Cambridge University Press
2011
Chitose Institute of Science and Technology
2011
Kyoto Medical Center
2007
Clinical Research Institute
2007
Kumamoto University
2007
Mochida Pharmaceutical (Japan)
2007
The University of Tokyo
2006
Previous studies demonstrated that obese adipose tissue is characterized by increased infiltration of macrophages, suggesting they might represent an important source inflammation. Using in vitro coculture system composed 3T3-L1 adipocytes and RAW264 we previously saturated fatty acids (FAs) tumor necrosis factor (TNF)-alpha derived from respectively, play a major role the coculture-induced inflammatory changes.Coculture macrophages resulted activation nuclear factor-kappaB (NF-kappaB),...
Objectives— Fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) or PUFAs have been shown to reduce the incidence of coronary heart disease. Here we investigated effect highly purified eicosapentaenoic acid (EPA) on production adiponectin, only established antiatherogenic and antiinflammatory adipocytokine, rodent models obesity human obese subjects. Methods Results— We demonstrated that EPA increases adiponectin secretion genetically ob/ob mice high-fat diet–induced mice. In vitro...
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they involved in disease progression from simple steatosis non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report unique histological structure termed “hepatic crown-like structures (hCLS)” mouse model human NASH; melanocortin-4 receptor deficient mice fed a Western diet. In hCLS, CD11c-positive aggregate surround hepatocytes with large lipid droplets, which similar...
Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) a key step. Although this process known to be cell cycle modulators, the precise mechanism remains unclear. N6-Methyladenosine (m6A) posttranscriptional RNA modification, whose methylation and demethylation are performed respective enzyme molecules, has recently been suggested involved in regulation adipogenesis. Here, we show that an N6-adenosine methyltransferase complex consisting Wilms'...
Accumulating evidence indicates that cell death triggers sterile inflammation and impaired clearance of dead cells causes nonresolving inflammation; however, the underlying mechanisms are still unclear. Here, we show macrophage-inducible C-type lectin (Mincle) senses renal tubular to induce sustained after acute kidney injury in mice. Mincle-deficient mice were protected against tissue damage subsequent atrophy ischemia-reperfusion injury. Using lipophilic extract from injured kidney,...
We investigated the effect of low molecular weight barley β-glucan (LMW-BG) on cecal fermentation, glucose, and lipid metabolism through comparisons to high (HMW-BG). C57BL/6J male mice were fed a moderate-fat diet for 61 days. LMW-BG or HMW-BG was added corresponding 4% β-glucan. measured apparent absorption fat, serum biomarkers, expression levels genes involved in glucose liver ileum, bacterial counts major microbiota groups using real time PCR. The concentration short-chain fatty acids...
Milk contains several components effective for bone health. In the previous in vitro and vivo studies, we have shown that milk whey protein, especially its basic protein fraction (milk [MBP]), promoted formation suppressed resorption. This present study examines effect of MBP on biochemical markers metabolism healthy adult men. Experimental beverages containing (300 mg a day) were given to 30 normal men 16 days. The serum osteocalcin concentration had increased significantly after days...
Abstract White rice is a dominant grain-based food in Japan, but excess intake of polished may cause obesity. Barley food, similar to white rice, it has the potential control appetite and reduce energy intake. We investigated effect cooked with high β-glucan barley on The study was conducted as randomized crossover design twenty-one healthy Japanese women [mean ± standard deviation body mass index (BMI) 23.3 0.7 kg/m 2 ]. Subjects consumed breakfast (BAR) or (WR), followed by an ad libitum...
Wheat bran (WB) is rich in insoluble arabinoxylan, while BARLEYmax (BM) a barley line that fructan, resistant starch, and β-glucan. In the present study, we investigated which of these two fiber sources would produce more favorable changes fecal variables healthy subjects. Sixty subjects were randomly divided into four groups (n = 15 per group) fed twice daily for 4 weeks with baked cereal bars containing neither WB nor BM (WB-BM-), without (WB+BM-), (WB-BM+), or (WB+BM+). At baseline after...
The aim of this study was to investigate the underlying mechanism for improvement glucose tolerance following intake high β-glucan barley (HGB) in terms intestinal metabolism. C57BL/6J male mice were fed a fatty diet supplemented with HGB corresponding 5% dietary fiber 83 days. An oral test performed at end experimental period. concentration short-chain acids (SCFAs) cecum analyzed by GC–MS (gas chromatography–mass spectrometry). mRNA expression levels related L cell function ileum measured...
Sphingomyelin (SPM) is the dominant phospholipid, comprising 38% of total human milk phospholipids. Although little known about nutritional importance SPM during neonatal period, may affect growth and development tissues in newborn infant through mechanisms regulating cell proliferation differentiation. We evaluated effect sphingomyelin artificially reared rats as a suitable model gut maturation suckling infant.Seven-day-old Sprague-Dawley rat pups were cannulated intragastrically on...
We evaluated whether intake of β-glucan-rich barley flour affects expression levels genes related to glucose and lipid metabolism in the ileum, liver, adipose tissues mice fed a high-fat diet. C57BL/6J male were diet supplemented with high β-glucan barley, for 92 days. measured involved using DNA microarray q-PCR. The concentration short-chain fatty acids (SCFAs) cecum was analyzed by GC/MS. metabolic syndrome indices improved intake. Microarray analysis showed that steroid synthesis...
Barley is rich in soluble dietary fiber including β-glucan and arabinoxylan. fermented by gut bacteria and, thereby contributes to an effect on intestinal bacterial composition short-chain fatty acids (SCFAs). It also increases GLP-1 secretion via SCFAs receptor. However, few studies have focused barley Therefore, we investigated the effects of arabinoxylan from fermentability secretion. C57BL/6J mice were fed a high-fat diet containing arabinoxylan-dominant flour without (bgl) high...