A5003766256- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Phagocytosis and Immune Regulation
- Acute Kidney Injury Research
Nagoya University
2020
Nonalcoholic steatohepatitis (NASH) is a hepatic phenotype of the metabolic syndrome, and increases risk cirrhosis hepatocellular carcinoma (HCC). Although increasing evidence points to therapeutic implications certain types anti-diabetic agents in NASH, it remains be elucidated whether their effects on NASH are independent diabetes. Genetically obese melanocortin 4 receptor-deficient (MC4R-KO) mice fed Western diet murine model that sequentially develops steatosis, HCC presence obesity...
Accumulating evidence indicates that cell death triggers sterile inflammation and impaired clearance of dead cells causes nonresolving inflammation; however, the underlying mechanisms are still unclear. Here, we show macrophage-inducible C-type lectin (Mincle) senses renal tubular to induce sustained after acute kidney injury in mice. Mincle-deficient mice were protected against tissue damage subsequent atrophy ischemia-reperfusion injury. Using lipophilic extract from injured kidney,...