A5052553271- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Phagocytosis and Immune Regulation
- Electrochemical sensors and biosensors
- Pancreatitis Pathology and Treatment
- Diabetes Management and Research
- Biomedical Research and Pathophysiology
- Multiple and Secondary Primary Cancers
- Lipid metabolism and biosynthesis
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Liver physiology and pathology
- Lung Cancer Treatments and Mutations
- Liver Diseases and Immunity
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Apelin-related biomedical research
- Diabetes Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
Nagoya University
2016-2025
Tokyo Medical and Dental University
1985-2014
Tokyo Metropolitan Institute of Gerontology
1995
University of Michigan
1995
Jikei University School of Medicine
1994
Katsushika Medical Center
1994
Kyoto University
1969
Kyoto University Hospital
1967
Although previous studies have attempted to create "electronics-free" insulin delivery systems using glucose oxidase and sugar-binding lectins as a glucose-sensing mechanism, no successful clinical translation has hitherto been made. These protein-based materials are intolerant of long-term use storage because their denaturing and/or cytotoxic properties. We provide solution by designing protein-free totally synthetic material-based approach. Capitalizing on the sugar-responsive properties...
Nonalcoholic steatohepatitis (NASH) is a hepatic phenotype of the metabolic syndrome, and increases risk cirrhosis hepatocellular carcinoma (HCC). Although increasing evidence points to therapeutic implications certain types anti-diabetic agents in NASH, it remains be elucidated whether their effects on NASH are independent diabetes. Genetically obese melanocortin 4 receptor-deficient (MC4R-KO) mice fed Western diet murine model that sequentially develops steatosis, HCC presence obesity...
Nutritional deprivation or malnutrition suppresses immune function in humans and animals, thereby conferring higher susceptibility to infectious diseases. Indeed, nutritional induces atrophy of lymphoid tissues such as thymus spleen decreases the number circulating lymphocytes. Leptin, a major adipocytokine, is exclusively produced adipose tissue response status acts on hypothalamus, regulating energy homeostasis. Although leptin plays critical role starvation-induced T-cell-mediated...
Abstract Non-alcoholic steatohepatitis (NASH) is characterized by steatosis with lobular inflammation and hepatocyte injury. Pirfenidone (PFD) an orally bioavailable pyridone derivative that has been clinically used for the treatment of idiopathic pulmonary fibrosis. However, it remains unknown whether PFD improves liver fibrosis in a mouse model human NASH-like phenotypes. In this study, we employed melanocortin 4 receptor-deficient (MC4R-KO) mice as phenotypes to elucidate effect action...
Accumulating evidence indicates that cell death triggers sterile inflammation and impaired clearance of dead cells causes nonresolving inflammation; however, the underlying mechanisms are still unclear. Here, we show macrophage-inducible C-type lectin (Mincle) senses renal tubular to induce sustained after acute kidney injury in mice. Mincle-deficient mice were protected against tissue damage subsequent atrophy ischemia-reperfusion injury. Using lipophilic extract from injured kidney,...
The molecular pathogenesis of nonalcoholic steatohepatitis (NASH) includes a complex interaction metabolic stress and inflammatory stimuli. Considering the therapeutic goals NASH, it is important to determine whether treatment can prevent progression from NASH hepatocellular carcinoma. Taxifolin, also known as dihydroquercetin, natural bioactive flavonoid with antioxidant anti-inflammatory properties commonly found in various foods health supplement products. In this study, we demonstrated...
<p dir="ltr">Recent evidence has shown that adipose tissue eventually develops fibrosis through complex cellular crosstalk. Although advances in single-cell transcriptomics have provided new insights into cell diversity during this process, little is known about the interactions among distinct types. In study, we employed analytical approaches to investigate cell-to-cell communications between macrophages and fibroblasts of diet-induced obese mice. Spatial was used understand local...
<p dir="ltr">Recent evidence has shown that adipose tissue eventually develops fibrosis through complex cellular crosstalk. Although advances in single-cell transcriptomics have provided new insights into cell diversity during this process, little is known about the interactions among distinct types. In study, we employed analytical approaches to investigate cell-to-cell communications between macrophages and fibroblasts of diet-induced obese mice. Spatial was used understand local...
Recent evidence has shown that adipose tissue eventually develops fibrosis through complex cellular crosstalk. Although advances in single-cell transcriptomics have provided new insights into cell diversity during this process, little is known about the interactions among distinct types. In study, we employed analytical approaches to investigate cell-tocell communications between macrophages and fibroblasts of diet-induced obese mice. Spatial was used understand local interaction within...
Abstract Proinflammatory cytokine production in macrophages involves multiple regulatory mechanisms, which are affected by environmental and intrinsic stress. In particular, accumulating evidence has suggested epigenetic control of macrophage differentiation function mainly vitro . SET domain, bifurcated 1 (Setdb1, also known as Eset) is a histone 3 lysine 9 (H3K9)-specific methyltransferase essential for early development embryos. Here we demonstrate that Setdb1 potently suppresses...
Although recent evidence suggests the involvement of iron accumulation in pathogenesis nonalcoholic steatohepatitis (NASH), underlying mechanisms remain poorly understood. Previously, we reported a unique histological structure termed "crown-like (CLS)," where liver-resident macrophages (Kupffer cells) surround dead hepatocytes, scavenge their debris, and induce inflammation fibrosis NASH. In this study, using magnetic column separation, show that iron-rich Kupffer cells exhibit...
Diabetes and obesity contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH) hepatocellular carcinoma (HCC). However, how diabetes accelerate liver tumorigenesis remains be fully understood. Moreover, verify therapeutic potential anti-diabetic drugs, there exists a strong need for appropriate animal models that recapitulate human pathophysiology NASH HCC. We established novel murine model NASH-associated tumors using genetically obese melanocortin 4 receptor-deficient mice fed...
Accumulating evidence demonstrates that not only sustained elevation of blood glucose levels but also the fluctuation represents key determinants for diabetic complications and mortality. Current closed-loop insulin therapy option is limited to use electronics-based systems, although it poses some technical issues with high cost. Here we demonstrate an electronics-free, synthetic boronate gel-based insulin-diffusion-control device technology can cope fluctuations potentially address...
Diabetes mellitus is the sixth leading cause of death. Traditional insulin injection not only involves pain, inconvenience, infection and nerve damage, but also difficult to achieve persistent glycemic control. Current “closed-loop” delivery systems are either electronics-derived or protein-based, concerns electrical failure immunetoxicity. Phenylboronic acid (PBA), which can reversibly bind with glucose, an attractive candidate for glucose sensing self-regulated as it does have denaturing...
The inhibitory effect of calcitonin on human pancreatic secretion was evaluated to examine whether the different results reported earlier between humans, cats and dogs can be ascribed sensitivity these species calcitonin, as suggested by some investigators. Pancreatic juice obtained endoscopic cannulation duct from 11 patients with relapsing pancreatitis during intravenous infusion secretin (1 U/kg/h) plus caerulein (0.04 microgram/kg/h). After steady attained 20 min after beginning...