Junko Tanaka
A5032472868- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Temporomandibular Joint Disorders
- Viral gastroenteritis research and epidemiology
- Glaucoma and retinal disorders
- T-cell and B-cell Immunology
- Liver Diseases and Immunity
- SARS-CoV-2 detection and testing
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- COVID-19 epidemiological studies
- Oral microbiology and periodontitis research
- Vaccine Coverage and Hesitancy
- Corneal surgery and disorders
- Dental Research and COVID-19
Hiroshima University
2016-2025
Osaka Dental University
2012-2024
Prevention Institute
2013-2024
UNSW Sydney
2024
Japanese Society for Dialysis Therapy
2022-2023
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2022
Hiroshima Prefectural Hospital
2004-2022
Hiroshima University Hospital
2022
Genesis Research Institute
2022
Center for Disease Analysis
2022
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis hepatocellular carcinoma globally. This burden is expected to increase as epidemics obesity, diabetes metabolic syndrome continue grow. The goal this analysis was use Markov model forecast NAFLD using currently available data.A used estimate NASH progression in eight countries based on data for adult prevalence obesity type 2 mellitus (DM). Published estimates expert...
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found about 10% patients with critical COVID-19 pneumonia, but not subjects asymptomatic infections. We detect auto-Abs 100-fold lower, more physiological, (100 pg/mL, 1/10 dilutions plasma) 13.6% 3,595 COVID-19, including 21% 374 > 80 years, and 6.5% 522 severe COVID-19. These antibodies also detected 18% the 1,124 deceased (aged 20 days-99 years; mean: 70...
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It important to estimate their quantitative impact on mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence these risk death increase with higher in men. Using an unvaccinated sample 1,261 deceased patients 34,159 individuals from general population, we found against IFNs strongly increased...
Abstract This cross-sectional study aimed to investigate the post-acute consequences of COVID-19. We conducted a self-administered questionnaire survey on sequelae, psychological distress (K6), impairments in work performance (WFun), and COVID-19–related experiences stigma discrimination two designated COVID-19 hospitals Hiroshima Prefecture, Japan, between August 2020 March 2021. The prevalence sequelae was calculated by age severity. Factors independently associated with or were identified...
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only three, plus IFN-ω five, and IFN-α2, IFN-β two; nine patients). Seven (3.8%) Abs at least ng/ml one IFN, whereas the other 12 (6.6%) 100 pg/ml. The auto-Abs neutralized both unglycosylated glycosylated IFNs. also detected pg/ml 4 2,267 uninfected (0.2%) 45 (2%). odds ratios (ORs) life-threatening were, therefore,...
<i>Objective:</i> Carriers of hepatitis B virus (HBV) and C (HCV) in Japan were estimated on a national basis. <i>Methods:</i> Sera from the first-time blood donors aged 16–64 years eight jurisdictions Japanese Red Cross Blood Center during 1995–2000 tested for surface antigen (HBsAg) antibody to HCV (anti-HCV). Viremia with was be present 70% anti-HCV. <i>Results:</i> HBsAg detected 22,018 3,485,648 (0.63%) including 12,990 1,780,149 (0.73%) men 9,028...
Background miRNAs circulating in the blood a cell-free form have been acknowledged for their potential as readily accessible disease markers. Presently, histological examination is golden standard diagnosing and grading liver disease, therefore non-invasive options are desirable. Here, we investigated if miRNA expression profile exosome rich fractionated serum could be useful determining parameters patients with chronic hepatitis C (CHC). Methodology Exosome RNA was extracted from of 64 CHC...
<i>Objective:</i> To estimate total numbers of undiagnosed carriers hepatitis C virus (HCV) and B (HBV) in Japan. <i>Methods:</i> Area- age-specific prevalence HCV as well HBV was determined the first-time blood donors [20–39 years (n = 2,429,364)] examinees periodical health check-ups [40–74 (6,204,968 for 6,228,967 HBV)] Prevalence adolescents [5–19 (79,256 68,792 a single prefecture, that elderly (≧75 years) estimated by exponential model. infection detection...
Objective: The aim of the study was to evaluate survival benefits liver resection (LR) compared with transarterial chemoembolization (TACE) for patients multiple hepatocellular carcinomas (HCCs). Background: Despite significant improvements in diagnostic imaging and widespread application screening programs, some HCC continue present tumors. surgical indications HCCs remain controversial. Methods: Among 77,268 reported a Japanese nationwide survey, 27,164 had HCCs. exclusion criteria were...
Background & AimsUltrasound-guided attenuation parameter (UGAP) is recently developed for noninvasive evaluation of steatosis. However, reports on its usefulness in clinical practice are limited. This prospective multicenter study analyzed the diagnostic accuracy grading steatosis with reference to magnetic resonance imaging–based proton density fat fraction (MRI-PDFF), a method high accuracy, large cohort.MethodsAltogether, 1010 patients chronic liver disease who underwent MRI-PDFF and UGAP...
The BNT162b2 and mRNA-1273 COVID-19 vaccines are the main that have been used for mass vaccination in Japan. Information on adverse reactions to Japanese population is limited.We conducted an online survey self-reported individuals who had received two doses of or vaccine. incidence events after each dose vaccine was investigated. Propensity score matching compare second vaccines.After first vaccine, 890, 853, 6401, 3965 individuals, respectively, provided complete responses. Systemic...
Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, mortality compared to (HBV) monoinfection. Reliable estimates prevalence HDV disease burden are essential formulate strategies find coinfected individuals more effectively efficiently. The global HBV infections was estimated be 262,240,000 in 2021. Only 1,994,000 were newly diagnosed 2021, than half new diagnoses made China. Our initial...
Abstract More than 200 million COVID-19 survivors have lasting symptoms after recovering, but the duration and related risk factors remain uncertain. This study focused on all 6551 patients diagnosed with at a medical institution in Hiroshima from March 2020 to July 2022. In November 2022, questionnaire survey was conducted regarding post-COVID their duration. The prevalence of were illustrated using Kaplan–Meier method. Risk for over 3 months interfering daily life assessed via multivariate...
Abstract: Recently, erythropoietin (EPO) receptors and synthesis of EPO have been identified in the brain. To clarify effects on neuronal cells, we investigated Ca 2+ uptake, intracellular concentration, membrane potential, cell survival, release biosynthesis dopamine, nitric oxide (NO) production differentiated PC12 which possess receptors. (10 ‐12 ‐10 M ) increased 45 uptake concentration cells a dose‐related manner; these increases were inhibited by nicardipine (1 μ or anti‐EPO antibody...
The purpose of the present study was to evaluate effectiveness Er:YAG laser scaling and morphological histological changes laser‐scaled root surface in comparison with produced by conventional ultrasonic scaling. Fifty‐three periodontally involved human extracted teeth a band subgingival calculus were used. divided randomly into 2 groups for Laser irradiation performed at an energy output 40 mJ/pulse 10 pulses/s under water spray, probe tip contacted obliquely surface. Ultrasonic clinically...
ABSTRACT Hepatitis B virus (HBV) infection is a leading cause of death in sub-Saharan Africa (SSA). Point-of-care tests for hepatitis surface antigen (HBsAg) could be an ideal tool large-scale HBV screening/treatment program SSA. Using data from the PROLIFICA (Prevention Liver Fibrosis and Cancer Africa) program, we conducted cross-sectional study to assess diagnostic accuracy three point-of-care (Determine, Vikia, Espline) detection HBsAg field or laboratory setting Gambia. In field, used...
Abstract Background Chronic spontaneous urticaria ( CSU ) is a common skin disorder, but its clinical course reported so far largely variable, probably due to the heterogeneity of background patients and pathogenesis this disease. Methods To reveal prognosis refractory , we retrospectively studied who suffered from for six weeks or longer at their first visit our outpatient clinic, were insufficiently controlled by standard dose antihistamine, revisited 2003 2009. Results Among 223 with 117...