A5020695380- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Liver Disease and Transplantation
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Genetic and phenotypic traits in livestock
- Global Public Health Policies and Epidemiology
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Molecular Biology Techniques and Applications
- Liver Diseases and Immunity
- Meat and Animal Product Quality
- Ferroelectric and Piezoelectric Materials
- Animal Genetics and Reproduction
- Diabetes Management and Research
- Health Promotion and Cardiovascular Prevention
- Bariatric Surgery and Outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- HIV, Drug Use, Sexual Risk
Hiroshima University
2017-2025
University of Medicine 2 Yangon
2012-2023
North Okkalapa General Hospital
2012-2023
University Of Medicine 1 Yangon
2011-2021
Ministry of Health
2020
Ministry of Health and Sports
2020
University of Dental Medicine
2020
University of Oslo
2017
Chungnam National University
2000-2012
CHA University
2008
Abstract More than 200 million COVID-19 survivors have lasting symptoms after recovering, but the duration and related risk factors remain uncertain. This study focused on all 6551 patients diagnosed with at a medical institution in Hiroshima from March 2020 to July 2022. In November 2022, questionnaire survey was conducted regarding post-COVID their duration. The prevalence of were illustrated using Kaplan–Meier method. Risk for over 3 months interfering daily life assessed via multivariate...
Abstract Background Fatty liver is frequently found in a general population, and it critical to detect advanced fibrosis. FIB-4 index considered useful marker for evaluating fibrosis but the distribution of population remains unknown. Methods This cross-sectional study included residents who underwent ultrasonography at health checkups Hiroshima or Iwate prefectures. The total (N = 75,666) as well non-alcoholic fatty disease (NAFLD) populations 17,968) non-drinkers without 47,222) was...
In this study, we performed molecular characterization of SARS-CoV-2 strains in Hiroshima and its mutation pattern between the first second waves outbreak.A total 55 nasal swab samples from wave 13 were examined quantitatively by RT-qPCR qualitatively nested PCR using specific primers. Four each underwent next-generation sequencing phylogenetic tree analysis including controls all sequences retrieved Japan GISAID GenBank. Subsequently, mutations examined.Viral load ranged 7.85 × 101-1.42 108...
Abstract Aim To estimate the weighted prevalence of hepatitis E virus (HEV) antibodies and risk factors among pregnant women in Burkina Faso to evaluate efficiency dried blood spots (DBS) detecting HEV antibodies. Methods We first evaluated DBS by comparing 62 with matched serum samples using recomWell IgG IgM kits (Mikrogen Diagnostik). Anti‐HEV immunoglobulin G (IgG) M (IgM) were identified 491 collected from kits. RNA was tested nested polymerase chain reaction HEV‐antibodies positive....
Myanmar adopted the World Health Organization (WHO) Package for Essential Non-Communicable Disease Interventions (PEN) in 20 pilot townships 2017. This study was conducted to assess implementation of PEN, its effectiveness and understand facilitators barriers implementation.Mixed methods design involving a quantitative component (retrospective analysing both aggregate individual patient data from PEN project records; cross-sectional facility survey using structured checklist) descriptive...
We estimated the total number of undiagnosed HBV and HCV carriers patients with hepatitis virus-related disease in Japan according to 6 different groups classified by their natural histories during 2011. In 2011, infected or was using government reports from epidemiology research group The Ministry Health, Labor Welfare Japan. virus be 2 090 128-2 840 128 which 776 826 (HBV: 481 470; HCV: 295 356). treated patients, as either inpatients outpatients, 811588 303 366; 520 600) It is presumed...
Abstract Although hepatitis B (HBV) and C (HCV) virus infections are still global health issues, measuring sero-markers by standard venipuncture is challenging in areas limited with the adequate human resources basic infrastructure. This study aimed to inform usefulness of dried blood spot (DBS) sampling technique for epidemiological HBV HCV areas. We compared specimen recovery rate expressed as analytical sensitivity ratio HBsAg, HBcAb anti-HCV between serum specimens DBS samples (HemaSpot...
In countries with intermediate or high hepatitis B virus (HBV) endemicity, mother-to-child transmission (MTCT) represents the main route of chronic HBV infection. There is a paucity information on MTCT in Cambodia. This study aimed to investigate prevalence infection among pregnant women and its rate Siem Reap, Cambodia.This longitudinal included two parts, study-1 screen HBsAg study-2 follow up babies all HBsAg-positive one-fourth HBsAg-negative mothers at their delivery six-month...
Abstract In highly endemic countries for hepatitis B virus (HBV) infection, childhood including mother-to-child transmission (MTCT), represents the primary route. High maternal DNA level (viral load ≥ 200,000 IU/mL) is a significant factor MTCT. We investigated prevalence of HBsAg, HBeAg, and high HBV among pregnant women in three hospitals Burkina Faso assessed performance HBeAg to predict viral load. Consenting were interviewed on their sociodemographic characteristics tested HBsAg by...
Abstract The burden of hepatitis E in Southeast Asia is substantial, influenced by its distinct socio-economic and environmental factors, as well variations healthcare systems. aim this study was to assess the pooled seroprevalence across countries within Asian region UN division. analyzed 66 papers PubMed, Web Science, Scopus databases, encompassing data from 44,850 individuals focusing on anti-HEV seroprevalence. investigation spanned nine countries, excluding Brunei East Timor due lack...
This study aimed to develop the feasible and effective universal screening strategy of notable SARS-CoV-2 variants by Sanger Sequencing Strategy then practically applied it for mass in Hiroshima, Japan. A total 734 samples from COVID-19 confirmed cases Hiroshima were screened (B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.1, C.37, B.1.1.529, etc.). The targeted spike region is amplified nested RT-PCR using in-house designed primer set hCoV-Spike-A standard amplification protocol. Additionally,...
Background: Myanmar, a low-income Southeast Asia country with an estimated population of 53.9 million, is currently facing increasing burden noncommunicable diseases. Research that systematically measures and reports the national prevalence diabetes prediabetes within Myanmar represents gap in literature. This study, survey, was conducted objectives 1) measuring diabetic population, 2) prediabetic 3) finding out risk factors leading to Myanmar. Method: Multistage sampling applied...
Background: Hepatitis B virus (HBV) infection is highly endemic in most low income countries including Cambodia. This nationwide serosurvey was conducted to assess the impact of hepatitis vaccination and determine whether Cambodia met WHO regional 2017 target surface antigen (HBsAg) seroprevalence less than 1% five-year-old children. Methods: A cross-sectional multi-stage cluster survey among children born during 2010–2012 their mothers HBsAg prevalence estimated by rapid point-of-care...
Abstract Background This study sought to provide up-to-date hepatitis B (HBV) and C (HCV) seroprevalence in rural Burkina Faso decade after vaccine was introduced the national immunization scheduled for children. Methods In 2018, a community-based, random sampling strategy with probability proportional population size conducted Nanoro investigate prevalence of viral children their mothers. Sociodemographic, vaccination history risk factors were assessed by interview health books. HBsAg rapid...
Hepatitis E virus (HEV) is a major global health issue, with an estimated 20 million infections annually. Although polymerase chain reaction (PCR) the diagnostic gold standard due to its precision, it expensive and technically demanding. Antibody tests offer more practical cost-effective alternative, although their accuracy can vary factors, such as test manufacturer, antigen composition, HEV genotype, host immune status.
Abstract Since the early 21 st century, almost all developed countries have had a very low hepatitis A virus antibody (anti-HAV) sero-prevalence profile, as sanitation conditions and health care facilities been optimized to universal standard. There has not report on anti-HAV prevalence among large scale population in Japan since 2003. Therefore, this study aimed investigate current HAV status general Hiroshima. From each age sex specific group, total of 1,200 samples were randomly selected...
Abstract Several factors related to anti-spike(S) IgG antibody titers after mRNA COVID-19 vaccination have been elucidated, but the magnitude of effects each factor has not fully understood. This cross-sectional study assessed anti-S and anti-nucleocapsid (N) on 3744 healthy volunteers (median age, 36 years; IQR, 24–49 females, 59.0%) who received two doses mRNA-1273 or BNT162b2 vaccine completed a survey questionnaire. Multiple regression was conducted identify associated with titers. All...
This study aimed to exercise the Sanger sequencing strategy for screening of variants among confirmed COVID-19 cases and validate our against NGS strains in Hiroshima retrieved from GISAID. A total 660 samples underwent by Sanger-based partial targeted spike gene (nt22,735~nt23,532) using an in-house-developed primer set. The identification was done unique checkpoints base nucleotide changes gene. Moreover, we amplified one full-length genome method library. Using same sampling period...
Hypertension is the leading risk factor for cardiovascular diseases, and little known about trends in prevalence, awareness, treatment control of hypertension Myanmar. This study aims at evaluating changes from 2004 to 2014 Yangon Region, Myanmar, compare associations between selected socio-demographic, behavioural- metabolic factors 2014. In 2014, household-based cross-sectional studies were conducted urban rural areas Region using WHO STEPS protocol. Through a multi-stage cluster sampling...
Health care workers (HCWs) are at high risk of contracting blood-borne infections including hepatitis B virus (HBV) infection. In Japan, all HCWs required to receive HB vaccination before beginning work. This study aimed investigate the dynamics surface antibody (anti-HBs) titer after a three-dose in and determine effective scheduling for non-responders. Subjects included 832 medical dental students who had received (Bimmugen® 0.5 ml/vial). Anti-HBs was measured three times (before third...
Fatty liver is the most common disease. This study examined fatty and advanced fibrosis prevalence in a random sample of Japanese general population.A total 6000 people randomly selected from two cities Hiroshima Prefecture were invited to participate this cross-sectional originally carried out for hepatitis virus screening. Ultrasonography FibroScan (controlled attenuation parameter [CAP] stiffness measurement [LSM]) provided as additional tests.Of individuals, 1043 participated screening,...
Abstract Background This study aimed to detect Hepatitis B virus (HBV) genome sequences and their variants as of nationwide scale using dried blood spot (DBS) samples provide up-to-date reference data for infection control surveillance in Cambodia. Method Among 2518 children age 5–7 years 2023 mothers participated 2017 Cambodia sero-survey on hepatitis surface antigen (HBsAg) prevalence multistage random sampling strategy, 95 13 positive HBsAg were included this study. HBV DNA was extracted...