A5010812320- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Liver Disease and Transplantation
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Liver Diseases and Immunity
- Hemoglobinopathies and Related Disorders
- Bacteriophages and microbial interactions
- Asthma and respiratory diseases
- Blood donation and transfusion practices
- Health Promotion and Cardiovascular Prevention
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immunotherapy and Immune Responses
- HIV, Drug Use, Sexual Risk
- Gastric Cancer Management and Outcomes
Hiroshima University
2016-2025
Soai University
2016
Prevention Institute
2016
Abstract This cross-sectional study aimed to investigate the post-acute consequences of COVID-19. We conducted a self-administered questionnaire survey on sequelae, psychological distress (K6), impairments in work performance (WFun), and COVID-19–related experiences stigma discrimination two designated COVID-19 hospitals Hiroshima Prefecture, Japan, between August 2020 March 2021. The prevalence sequelae was calculated by age severity. Factors independently associated with or were identified...
The BNT162b2 and mRNA-1273 COVID-19 vaccines are the main that have been used for mass vaccination in Japan. Information on adverse reactions to Japanese population is limited.We conducted an online survey self-reported individuals who had received two doses of or vaccine. incidence events after each dose vaccine was investigated. Propensity score matching compare second vaccines.After first vaccine, 890, 853, 6401, 3965 individuals, respectively, provided complete responses. Systemic...
Abstract More than 200 million COVID-19 survivors have lasting symptoms after recovering, but the duration and related risk factors remain uncertain. This study focused on all 6551 patients diagnosed with at a medical institution in Hiroshima from March 2020 to July 2022. In November 2022, questionnaire survey was conducted regarding post-COVID their duration. The prevalence of were illustrated using Kaplan–Meier method. Risk for over 3 months interfering daily life assessed via multivariate...
Abstract Background Fatty liver is frequently found in a general population, and it critical to detect advanced fibrosis. FIB-4 index considered useful marker for evaluating fibrosis but the distribution of population remains unknown. Methods This cross-sectional study included residents who underwent ultrasonography at health checkups Hiroshima or Iwate prefectures. The total (N = 75,666) as well non-alcoholic fatty disease (NAFLD) populations 17,968) non-drinkers without 47,222) was...
Determining the number of chronic hepatitis B (HBV) and C virus (HCV) infections is essential to assess progress towards World Health Organization 2030 viral elimination goals. Using data from Japanese National Database (NDB), we calculated HBV HCV in 2015 predicted trend until 2035.NDB first-time blood donors were used calculate 2015. A Markov simulation was applied predict 2035 using transition probabilities NDB data.The total Japan 1,905,187-2,490,873 (HCV:877,841-1,302,179,...
In this study, we performed molecular characterization of SARS-CoV-2 strains in Hiroshima and its mutation pattern between the first second waves outbreak.A total 55 nasal swab samples from wave 13 were examined quantitatively by RT-qPCR qualitatively nested PCR using specific primers. Four each underwent next-generation sequencing phylogenetic tree analysis including controls all sequences retrieved Japan GISAID GenBank. Subsequently, mutations examined.Viral load ranged 7.85 × 101-1.42 108...
Abstract Aim To estimate the weighted prevalence of hepatitis E virus (HEV) antibodies and risk factors among pregnant women in Burkina Faso to evaluate efficiency dried blood spots (DBS) detecting HEV antibodies. Methods We first evaluated DBS by comparing 62 with matched serum samples using recomWell IgG IgM kits (Mikrogen Diagnostik). Anti‐HEV immunoglobulin G (IgG) M (IgM) were identified 491 collected from kits. RNA was tested nested polymerase chain reaction HEV‐antibodies positive....
Simulation studies were performed to predict the future supply and demand for blood donations, shortfalls.Using data from all donations in 2006 2009, Markov model was applied estimate until 2050. Based on concerning actual use of products, number products needed estimated based population projections.We that increased 5,020,000 2008 5,260,000 2012, but will decrease 4,770,000 units by 2025. In particular, donors their 20s 30s decreased every year. Moreover, required would have been 5,390,000...
The Tokyo subway sarin attack in 1995 was an unprecedented act of terrorism that killed 13 people and sickened more than 6,000. long-term somatic psychological effects on its victims remain unknown.We conducted analyses the self-rating questionnaire collected annually by Recovery Support Center (RSC) during period from 2000 to 2009. RSC is only organization has large-scale follow-up data about victims. prevalence self-reported symptoms calculated over 10 years. We also evaluated...
In countries with intermediate or high hepatitis B virus (HBV) endemicity, mother-to-child transmission (MTCT) represents the main route of chronic HBV infection. There is a paucity information on MTCT in Cambodia. This study aimed to investigate prevalence infection among pregnant women and its rate Siem Reap, Cambodia.This longitudinal included two parts, study-1 screen HBsAg study-2 follow up babies all HBsAg-positive one-fourth HBsAg-negative mothers at their delivery six-month...
Introduction: The burden of epilepsy is thought to be high but difficult measure. Very few studies in Japan have attempted estimate prevalence and incidence rates Japan.
Abstract In highly endemic countries for hepatitis B virus (HBV) infection, childhood including mother-to-child transmission (MTCT), represents the primary route. High maternal DNA level (viral load ≥ 200,000 IU/mL) is a significant factor MTCT. We investigated prevalence of HBsAg, HBeAg, and high HBV among pregnant women in three hospitals Burkina Faso assessed performance HBeAg to predict viral load. Consenting were interviewed on their sociodemographic characteristics tested HBsAg by...
Abstract The burden of hepatitis E in Southeast Asia is substantial, influenced by its distinct socio-economic and environmental factors, as well variations healthcare systems. aim this study was to assess the pooled seroprevalence across countries within Asian region UN division. analyzed 66 papers PubMed, Web Science, Scopus databases, encompassing data from 44,850 individuals focusing on anti-HEV seroprevalence. investigation spanned nine countries, excluding Brunei East Timor due lack...
This study aimed to develop the feasible and effective universal screening strategy of notable SARS-CoV-2 variants by Sanger Sequencing Strategy then practically applied it for mass in Hiroshima, Japan. A total 734 samples from COVID-19 confirmed cases Hiroshima were screened (B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.1, C.37, B.1.1.529, etc.). The targeted spike region is amplified nested RT-PCR using in-house designed primer set hCoV-Spike-A standard amplification protocol. Additionally,...
Background: Hepatitis B virus (HBV) infection is highly endemic in most low income countries including Cambodia. This nationwide serosurvey was conducted to assess the impact of hepatitis vaccination and determine whether Cambodia met WHO regional 2017 target surface antigen (HBsAg) seroprevalence less than 1% five-year-old children. Methods: A cross-sectional multi-stage cluster survey among children born during 2010–2012 their mothers HBsAg prevalence estimated by rapid point-of-care...
Abstract Background This study sought to provide up-to-date hepatitis B (HBV) and C (HCV) seroprevalence in rural Burkina Faso decade after vaccine was introduced the national immunization scheduled for children. Methods In 2018, a community-based, random sampling strategy with probability proportional population size conducted Nanoro investigate prevalence of viral children their mothers. Sociodemographic, vaccination history risk factors were assessed by interview health books. HBsAg rapid...
Hepatitis E virus (HEV) is a major global health issue, with an estimated 20 million infections annually. Although polymerase chain reaction (PCR) the diagnostic gold standard due to its precision, it expensive and technically demanding. Antibody tests offer more practical cost-effective alternative, although their accuracy can vary factors, such as test manufacturer, antigen composition, HEV genotype, host immune status.
Abstract Several factors related to anti-spike(S) IgG antibody titers after mRNA COVID-19 vaccination have been elucidated, but the magnitude of effects each factor has not fully understood. This cross-sectional study assessed anti-S and anti-nucleocapsid (N) on 3744 healthy volunteers (median age, 36 years; IQR, 24–49 females, 59.0%) who received two doses mRNA-1273 or BNT162b2 vaccine completed a survey questionnaire. Multiple regression was conducted identify associated with titers. All...
Airway resistance and reactance measured by forced oscillometry have been used to measure the severity of airway obstruction in chronic obstructive pulmonary disease (COPD) patients. The aims this study were assess effects tachypnoea on correlate these with dyspnoea. We also evaluated short-acting β2-agonist (SABA) measurements.Airway an impulse oscillation system (IOS) 20 COPD 10 control participants during resting respiration metronome-paced breathing at 20, 30 40 tidal breaths/min. same...
国民調査による肝炎ウイルス検査の認識受検率は,B型肝炎ウイルス(HBV)検査17.8%,C型肝炎ウイルス(HCV)検査17.7%と低い値であった.受検したことを認識していない非認識受検者を合わせた受検率は,HBV検査57.7%,HCV検査48.1%であった.肝炎ウイルス検査受検の促進要因の検討により,肝炎ウイルス検査や症状・治療の知識を広めることが促進要因であることが明らかとなった.1都6県の自治体で実施した検査後の肝炎ウイルス陽性者(2,177人)の意識動向調査では,検査結果「陽性」を正しく認識していたのは75.4%であり,医療機関受診率は陽性者の66.2%であった.肝炎ウイルス検査の受検を促進するだけでなく,肝炎ウイルス陽性者の医療機関受診率向上を目指すことが今後の課題であり,そのためには肝炎に対する正しい知識の普及と医療機関受診及び継続受診に繋げるための体制の整備が急務であることが示唆された.
This study aimed to exercise the Sanger sequencing strategy for screening of variants among confirmed COVID-19 cases and validate our against NGS strains in Hiroshima retrieved from GISAID. A total 660 samples underwent by Sanger-based partial targeted spike gene (nt22,735~nt23,532) using an in-house-developed primer set. The identification was done unique checkpoints base nucleotide changes gene. Moreover, we amplified one full-length genome method library. Using same sampling period...
Health care workers (HCWs) are at high risk of contracting blood-borne infections including hepatitis B virus (HBV) infection. In Japan, all HCWs required to receive HB vaccination before beginning work. This study aimed investigate the dynamics surface antibody (anti-HBs) titer after a three-dose in and determine effective scheduling for non-responders. Subjects included 832 medical dental students who had received (Bimmugen® 0.5 ml/vial). Anti-HBs was measured three times (before third...
Fatty liver is the most common disease. This study examined fatty and advanced fibrosis prevalence in a random sample of Japanese general population.A total 6000 people randomly selected from two cities Hiroshima Prefecture were invited to participate this cross-sectional originally carried out for hepatitis virus screening. Ultrasonography FibroScan (controlled attenuation parameter [CAP] stiffness measurement [LSM]) provided as additional tests.Of individuals, 1043 participated screening,...