A5076307000- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 and Mental Health
- Epilepsy research and treatment
- Diet, Metabolism, and Disease
- Nutrition and Health in Aging
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Health Promotion and Cardiovascular Prevention
- SARS-CoV-2 detection and testing
- Pharmacological Effects and Toxicity Studies
- Psychosomatic Disorders and Their Treatments
- Viral Infections and Immunology Research
- Advanced Biosensing Techniques and Applications
- Immunotherapy and Immune Responses
- Hemoglobinopathies and Related Disorders
- Alcohol Consumption and Health Effects
- Healthcare Systems and Reforms
Hiroshima University
2018-2024
The BNT162b2 and mRNA-1273 COVID-19 vaccines are the main that have been used for mass vaccination in Japan. Information on adverse reactions to Japanese population is limited.We conducted an online survey self-reported individuals who had received two doses of or vaccine. incidence events after each dose vaccine was investigated. Propensity score matching compare second vaccines.After first vaccine, 890, 853, 6401, 3965 individuals, respectively, provided complete responses. Systemic...
Abstract More than 200 million COVID-19 survivors have lasting symptoms after recovering, but the duration and related risk factors remain uncertain. This study focused on all 6551 patients diagnosed with at a medical institution in Hiroshima from March 2020 to July 2022. In November 2022, questionnaire survey was conducted regarding post-COVID their duration. The prevalence of were illustrated using Kaplan–Meier method. Risk for over 3 months interfering daily life assessed via multivariate...
Abstract Background Fatty liver is frequently found in a general population, and it critical to detect advanced fibrosis. FIB-4 index considered useful marker for evaluating fibrosis but the distribution of population remains unknown. Methods This cross-sectional study included residents who underwent ultrasonography at health checkups Hiroshima or Iwate prefectures. The total (N = 75,666) as well non-alcoholic fatty disease (NAFLD) populations 17,968) non-drinkers without 47,222) was...
Determining the number of chronic hepatitis B (HBV) and C virus (HCV) infections is essential to assess progress towards World Health Organization 2030 viral elimination goals. Using data from Japanese National Database (NDB), we calculated HBV HCV in 2015 predicted trend until 2035.NDB first-time blood donors were used calculate 2015. A Markov simulation was applied predict 2035 using transition probabilities NDB data.The total Japan 1,905,187-2,490,873 (HCV:877,841-1,302,179,...
Introduction: The burden of epilepsy is thought to be high but difficult measure. Very few studies in Japan have attempted estimate prevalence and incidence rates Japan.
Abstract Several factors related to anti-spike(S) IgG antibody titers after mRNA COVID-19 vaccination have been elucidated, but the magnitude of effects each factor has not fully understood. This cross-sectional study assessed anti-S and anti-nucleocapsid (N) on 3744 healthy volunteers (median age, 36 years; IQR, 24–49 females, 59.0%) who received two doses mRNA-1273 or BNT162b2 vaccine completed a survey questionnaire. Multiple regression was conducted identify associated with titers. All...
Background Long‐term prognosis of patients with chronic hepatitis C infection (HCV) remains incompletely characterized. We investigated the long‐term liver disease in HCV who have not received antiviral therapy. Methods A total 2304 were interferon‐based therapy included. Results In assessment 1‐year state transition probabilities, progression to occurred 12% 14% across all age groups male asymptomatic carriers. hepatitis, cirrhosis was observed mostly 60 69 (7.6%) and ≥70 (9.6%). addition,...
Abstract Background & Aims The relationship between the frequency of drinking and fatty liver in general population is still poorly understood. This study analysed data from a large cohort who underwent health checkups Japan 2008 2019 to investigate prevalence incidence by alcohol consumption risk factors for liver. Methods diagnosed with ultrasonography was calculated 75,670 residents. 31,062 residents at least twice during period without first time using person‐year method....
Abstract Background and Aim We conducted a study using the Fibrosis‐3 (FIB‐3) index, which is established age‐independent index of fibrosis in nonviral liver disease addresses limitations FIB‐4 older age group, to assess risk among diverse demographic groups general population. Methods analyzed 31 327 individuals who underwent health examinations between 2013 2020 investigated distribution FIB‐3 by group. In addition, we examined stratified background factors, such as sex, body mass (BMI),...
We estimated the cost-effectiveness of direct-acting antiviral treatment (DAA) compared to triple therapy (simeprevir, pegylated interferon-α [Peg-IFN], and ribavirin [RBV]) (scenario 1), Peg-IFN + RBV 2), non-antiviral 3).Cost-effectiveness was evaluated as incremental ratios (ICERs) using direct costs indirect costs, which included loss wages during patient's lifetime due early death caused by viral hepatitis infection. Quality life (QOL) scores were determined EQ-5D-3L questionnaire...
BACKGROUND The classification of many new cases hepatitis virus infection as overt does not reflect the true incidence because disease takes an asymptomatic course in some cases. In this retrospective cohort study, we aimed to estimate rates C (HCV) infections among blood donors. STUDY DESIGN AND METHOD A 5‐year study was conducted by using medical records donors between 2008 and 2013 for HCV infection. seroconversions were investigated a chemiluminescent enzyme immunoassay then confirmed...
Antiviral therapy advancements resulted in an era which eradication of hepatitis C has become a goal, however, there are few reports on the long-term course liver disease progression with antiviral therapy. The aim this study was to use Markov model analyze and non-invasive fibrosis index Patients.Patients chronic (n = 1432) were diagnosed between January 2012 May 2021 Musashino Red Cross Hospital. Patients other virus co-infection, disease, hepatocellular carcinoma (HCC) at beginning...
Abstract Perceived discrimination and work impairment are commonly observed in COVID-19 survivors, but their relationship has not been well understood. We aimed to evaluate the role of development psychological distress survivors. From April 2020 November 2021, 309 patients were recruited at two designated hospitals Japan. Participants completed a standardized questionnaire including sequelae, distress, impairments performance perceived discrimination. The majority participants (62.5%)...
Symptoms after novel coronavirus disease 2019 (COVID-19) recovery by severe acute respiratory syndrome 2 strains are unspecified.
The long-term prognosis of patients with chronic hepatitis C virus (HCV) infection who have received antiviral therapy and demonstrate HCV eradication remains incompletely characterized. In this study, we investigated the liver disease in HCV.A total 552 (6815 person-years) were treated interferon-based achieved sustained virologic response included. Yearly transition probabilities for each state (chronic hepatitis, cirrhosis, hepatocellular carcinoma [HCC]) calculated using a Markov chain...
Even during nucleos(t)ide analogue therapy, development of hepatocellular carcinoma (HCC) has been observed in patients with chronic hepatitis B virus (HBV) infection. We simulated the long-term prognosis liver disease HBV who received therapy.A total 254 receiving therapy were enrolled. Yearly transition probabilities between states [chronic hepatitis, cirrhosis, HCC, and surface antigen (HBsAg)-negative status] calculated using a Markov chain model.In analysis 1-year state probabilities,...
Abstract This population‐based study examined the natural course of hepatitis B e antigen (HBeAg)‐positive or HBeAg‐negative persistent virus (HBV) infection, adjusted by age and liver disease states using a Markov model. Using 12 417 person‐years data (n = 862), annual transition probabilities were estimated, age‐adjusted cumulative incidence history HBV infection simulated in both sexes groups 1 (HBeAg‐negative status with DNA level <4.0 log IU/mL at entry) 2 (persistent HBeAg‐positive...
Commercially available assays for measuring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-spike (S) or anti-nucleocapsid (N) antibodies differ in units, making results comparisons challenging. This study aimed to develop conversion equations between five quantitative anti-S antibody tests and assess the agreement over time three qualitative anti-N tests. Blood samples from 24 216 vaccinated healthcare workers Hiroshima Prefecture, Japan, were analyzed using (Abbott,...
To investigate the long-term prognosis of liver disease in patients with hepatitis C virus (HCV) eradication after antiviral therapy versus those persistent HCV infection. Four hundred and eighty (5259 person-years [PYs]) who received interferon-based achieved sustained virologic response 848 (3853 PYs) infection were included. In analysis 1-year state transition probability matrices using Markov chain models, progression to cirrhosis from chronic was observed (0.00%-0.63%) eradication....
The diagnosis of NASH requires a liver biopsy; however, actual clinical practice is unknown. In this study, we analyzed large database medical claims from 2013 to 2017, which included 7, 368, 327 insured people. number people newly diagnosed with was 2, 224. Among these, 153 (6.9%) had received biopsies in the three months prior new diagnosis. elderly higher rate biopsy implementation. Over last 5 years, there been no change implementation biopsies. According findings it desirable develop an...
Background: Determining the number of chronic hepatitis B (HBV) and C virus (HCV) infections is essential to assess progress towards World Health Organization 2030 viral elimination goals. Using data from Japanese National Database (NDB), we calculated HBV HCV in 2015 predicted trend until 2035.Methods: NDB first-time blood donors were used calculate 2015. A Markov simulation was applied predict 2035 using transition probabilities data.Findings: The total Japan 2,001,221–2,487,881...