A5044269436- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS drug development and treatment
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Pancreatic and Hepatic Oncology Research
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Hepatitis Viruses Studies and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Liver Diseases and Immunity
- Animal Virus Infections Studies
- Endoplasmic Reticulum Stress and Disease
Hiroshima University
2016-2025
Hiroshima University Hospital
2008-2025
Life Science Institute
2015-2025
Weatherford College
2024
RIKEN Center for Integrative Medical Sciences
2010-2018
RIKEN
2011-2018
Japanese Red Cross Nagoya Daini Hospital
2016
Center for Genomic Science
2011-2016
Frontier Medical College
2011
The University of Tokyo
2008-2010
Hepatitis B virus (HBV) infection is a major health issue worldwide which may lead to hepatic dysfunction, liver cirrhosis and hepatocellular carcinoma. To identify host genetic factors that are associated with chronic hepatitis (CHB) susceptibility, we previously conducted two-stage genome-wide association study (GWAS) identified the of HLA-DP variants CHB in Asians; however, only 179 cases 934 controls were genotyped using single nucleotide polymorphism (SNP) arrays. Here, performed second...
Pegylated interferon, ribavirin, and telaprevir triple therapy is a new strategy expected to eradicate the hepatitis C virus (HCV) even in patients infected with difficult-to-treat genotype 1 strains, although adverse effects, such as anemia rash, are frequent.We assessed efficacy predictive factors for sustained virological response (SVR) 94 Japanese HCV 1. We included recently identified factors, IL28B ITPA polymorphism, substitutions core NS5A proteins.Patients treated achieved...
This study aims to isolate potential molecular targets for diagnosis, treatment, and/or prevention of lung and esophageal carcinomas.We screened genes that were frequently overexpressed in the tumors through gene expression profile analyses 101 cancers 19 squamous cell carcinomas (ESCC) by cDNA microarray consisting 27,648 or expressed sequence tags. In this process, we identified epithelial transforming 2 (ECT2) as a candidate. Tumor tissue was applied examine ECT2 protein 242 archived...
<h3>Background and aims</h3> A number of recent studies have shown that human polymorphisms near the <i>IL28B</i> type III interferon (IFNλ) gene influence response to peg-interferon plus ribavirin combination therapy for infection with chronic hepatitis C virus (HCV). Viral polymorphisms, including substitutions within HCV core NS5A proteins, also been treatment outcome, but it is not known whether these factors act independently IL28B polymorphism or if they reflect same a different...
The non-structural X protein, HBx, of hepatitis B virus (HBV) is assumed to play an important role in HBV replication. Woodchuck protein indispensable for replication, but the duck not. In this study, we investigated whether HBx replication vivo using human hepatocyte chimeric mice. HBx-deficient (HBx-def) was generated HepG2 cells by transfection with overlength genome. Human mice were infected HBx-def or without hepatic expression hydrodynamic injection plasmids. Serum levels and sequences...
Circulating tumor DNA (ctDNA) carrying tumor-specific sequence alterations has been found in the cell-free fraction of blood. Liver cancer specimens are difficult to obtain, and noninvasive methods required assess progression characterize underlying genomic features.We analyzed 46 patients with hepatocellular carcinoma who underwent hepatectomy or liver transplantation for whom whole-genome sequencing data was available. We designed personalized assays targeting somatic rearrangements each...
Abstract Hepatitis B virus (HBV) infection is associated with increased expression of microRNA‐122. Serum microRNA‐122 and microRNA‐22 levels were analyzed in 198 patients chronic HBV who underwent liver biopsy compared quantitative measurements HBsAg, HBeAg, DNA, other clinical histological findings. Levels serum determined by reverse transcription‐TaqMan PCR. correlated (R 2 = 0.576; P < 0.001), both elevated patients. Significant linear correlations found between or HBsAg 0.824, 0.001...
Background Vitamin D insufficiency has been associated with the occurrence of various types cancer, but causal relationships remain elusive. We therefore aimed to determine relationship between genetic determinants vitamin serum levels and risk developing hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). Methodology/Principal Findings Associations CYP2R1, GC, DHCR7 genotypes that are reduced 25-hydroxyvitamin (25[OH]D3) HCV-related HCC development were investigated for 1279...
We assessed the risk factors for development of hepatocellular carcinoma (HCC) following successful eradication hepatitis C virus (HCV) with interferon (IFN) therapy in a long-term, large-scale cohort study.We reviewed 1094 consecutive patients HCV who achieved sustained virological response (SVR) IFN between January 1995 and September 2013.During observation period (median 50 months: range 13-224), 36 (3%) developed HCC after SVR. The median from SVR to diagnosis was 37 months (range...
Hepatitis C virus (HCV) infection is the major cause of hepatocellular carcinoma (HCC) in Japan. We previously identified association SNP rs2596542 5' flanking region MHC class I polypeptide-related sequence A (MICA) gene with risk HCV-induced HCC. In current study, we performed detailed functional analysis 12 candidate SNPs promoter and found that a rs2596538 located at 2.8 kb upstream MICA affected binding nuclear protein(s) to genomic segment including this SNP. By electrophoretic...
The risk of hepatocellular carcinoma (HCC) development is reduced following viral elimination by interferon therapy in chronic hepatitis C patients. However, the patients treated with interferon-free direct-acting antivirals (DAAs) unknown. We evaluated who achieved eradication pegylated-interferon plus ribavirin (PEG-IFN/RBV, n = 244) or daclatasvir asunaprevir (DCV/ASV, 154) therapy. None had prior history HCC antiviral median observation period after end treatment for PEG-IFN/RBV and...
Although the effect of levocarnitine (L-carnitine) on hyperammonemia has been reported in patients with liver cirrhosis (LC), its sarcopenia remains to be elucidated. We assessed effects L-carnitine LC. retrospectively evaluated 52 LC who were treated for more than 3 months between February 2013 and June 2017. Computed tomography was used measure cross-sectional area skeletal muscles at level third lumbar vertebra. The relative change muscle index (SMI) per year (ΔSMI/year) computed each...
OBJECTIVES: Biomarkers for optimizing the outcome of treatment with lenvatinib in patients advanced hepatocellular carcinoma remain to be established despite intensive and comprehensive genomic research. Lenvatinib is characterized by its prominent inhibitory potency fibroblast growth factor receptor (FGFR) 4 compared earlier tyrosine kinase inhibitors. Thus, this study, we focused on simplified quantification FGFR4 tumors as a potential predictive indicator. METHODS: According The Cancer...