A5038862421- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- BRCA gene mutations in cancer
- Asymmetric Synthesis and Catalysis
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Chemical Synthesis and Reactions
- Asymmetric Hydrogenation and Catalysis
- Sarcoma Diagnosis and Treatment
- Synthetic Organic Chemistry Methods
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Cancer-related gene regulation
- Anorectal Disease Treatments and Outcomes
- Oxidative Organic Chemistry Reactions
- Cancer Immunotherapy and Biomarkers
- Chemical Synthesis and Analysis
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Intraperitoneal and Appendiceal Malignancies
- Mycotoxins in Agriculture and Food
Japanese Foundation For Cancer Research
2015-2024
The Cancer Institute Hospital
2015-2024
Kyoto University
2008-2024
Suita Tokushukai Hospital
2021-2024
Fukuoka Tokushukai Hospital
2023
Tokyo University of Science
1987-2022
The University of Tokyo
1999-2022
Kyushu University Beppu Hospital
2022
Japanese Red Cross Medical Center
2022
Higashi Takarazuka Satoh Hospital
2016-2018
Laparoscopic rectal surgery involving transection and anastomosis with stapling devices is technically difficult. The aim of this study was to evaluate the risk factors for anastomotic leakage (AL) after laparoscopic low anterior resection (LAR) double-stapling technique (DST) anastomosis.This a retrospective single-institution 154 cancer patients who underwent LAR DST between June 2005 August 2013. Patient-, tumor-, surgery-related variables were examined by univariate multivariate...
Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little currently known about whether and how causally CRC development. Here we show 12 faecal bacterial taxa enriched patients two independent cohort studies. Among them, 2 Porphyromonas species capable of inducing cellular senescence, an oncogenic stress response, through the secretion metabolite, butyrate. Notably, invasion these bacteria observed tissues, coinciding...
The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In current study, we investigate whether events occurring at invasion front particular importance for CRC treatment strategies. To this end, analyze tissues by combining spatial transcriptomics from patients with a public single-cell transcriptomic atlas to determine cell-cell front. We show that cells localized specifically These induce human leukocyte...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTLewis Acid Catalysts Stable in Water. Correlation between Catalytic Activity Water and Hydrolysis Constants Exchange Rate for Substitution of Inner-Sphere LigandsShū Kobayashi, Satoshi Nagayama, Tsuyoshi BusujimaView Author Information Department Applied Chemistry, Faculty Science University Tokyo (SUT) CREST, Japan Technology Corporation (JST) Kagurazaka, Shinjuku-ku, 162 Cite this: J. Am. Chem. Soc. 1998, 120, 32, 8287–8288Publication Date...
A Lewis acid−surfactant-combined catalyst (LASC) has been developed and applied to acid-catalyzed organic reactions in water. LASCs are composed of water-stable acidic cations such as scandium anionic surfactants dodecyl sulfate dodecanesulfonate easily prepared. These catalysts have successfully used for various typical carbon−carbon bond-forming aldol, allylation, Mannich-type Furthermore, the results aldol solvents show that water is best solvent LASC-catalyzed reactions. preliminary...
Abstract Purpose: Human invariant natural killer T (NKT) cells are novel, distinct lymphocyte populations with a restricted T-cell receptor repertoire (Vα24-Vβ11). They play pivotal role in immunoregulation and antitumor activities. This study focused on Vα24+ NKT colorectal carcinomas their clinicopathologic significance. Experimental Design: NKT-cell infiltration immunohistochemistry was studied total of 103 carcinoma cases. The degree tumors evaluated as low (<7 cells/5 HPF) or...
A collection of structurally complex and chemically diverse small molecules is a useful tool to explore cell circuitry. In this article, we report the split-pool synthesis more than 3000 spirooxindoles on high capacity macrobeads. The key reaction assemble spirooxindole core stereoselectively Lewis acid variant Williams' three-component coupling. After formation, skeleton was elaborated using Sonogashira couplings, amide forming reactions, N-acylations γ-lactams. final library analyzed by...
Lanthanide triflate catalyzed imino Diels-Alder reactions of imines with dienes or alkenes have been developed. A new group Lewis acids, lanthanide triflates, are quite effective for the catalytic activation imines. Unique reactivities which work as both dienophiles and azadienes under certain conditions revealed. Three-component coupling between aldehydes, amines, were successfully carried out by using a catalyst to afford pyridine quinoline derivatives in high yields. The acid catalysts...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Microencapsulated Lewis Acid. A New Type of Polymer-Supported Acid Catalyst Wide Utility in Organic SynthesisShū Kobayashi and Satoshi NagayamaView Author Information Department Applied Chemistry, Faculty Science University Tokyo (SUT) CREST, Japan Technology Corporation (JST) Kagurazaka, Shinjuku-ku, 162, Cite this: J. Am. Chem. Soc. 1998, 120, 12, 2985–2986Publication Date (Web):March 17, 1998Publication History Received17 November...
To implement personalized medicine, we established a large-scale patient cohort, BioBank Japan, in 2003. Japan contains DNA, serum, and clinical information derived from approximately 200,000 patients with 47 diseases. Serum were collected annually until 2012.We analyzed of participants at enrollment, including age, sex, body mass index, hypertension, smoking drinking status, across diseases, compared the results Japanese database on Patient Survey National Health Nutrition Survey. We...
Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor observed, from which inferred history First, clonally shared alterations appeared, C>T transitions at CpG site island hypermethylation were relatively enriched. Correlation between mutation counts patients' ages suggests...
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, in precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten early tumors, which contained adenoma and carcinoma situ. By comparing with data from advanced we show that the tumors accumulate a higher proportion of subclonal driver mutations than is highlighted KRAS APC. also demonstrate variant allele frequencies tend to be suggesting are...
Abstract The large majority of variants identified by GWAS are non-coding, motivating detailed characterization the function non-coding variants. Experimental methods to assess variants’ effect on gene expressions in native chromatin context via direct perturbation low-throughput. Existing high-throughput computational predictors thus have lacked gold standard sets regulatory for training and validation. Here, we leverage a set 14,807 putative causal eQTLs humans obtained through statistical...
Extracellular vesicles (EVs) are ubiquitously secreted by almost all tissues and carry many cargoes, including proteins, RNAs, lipids, which related to various biological processes. EVs shed from into the blood expected be used as biomarkers for diseases. Here, we isolated EDTA plasma serum of six healthy subjects an affinity capture isolation method, a total 4,079 proteins were successfully identified comprehensive EV proteomics. Our reliable detailed catalog differential expression...