A5103144232- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Multimodal Machine Learning Applications
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Domain Adaptation and Few-Shot Learning
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- Lung Cancer Research Studies
- Functional Brain Connectivity Studies
- Natural Language Processing Techniques
- Advanced Image and Video Retrieval Techniques
- Cytokine Signaling Pathways and Interactions
- Gene expression and cancer classification
- Adipose Tissue and Metabolism
- Nuclear Engineering Thermal-Hydraulics
- Adversarial Robustness in Machine Learning
- Pesticide and Herbicide Environmental Studies
- Anomaly Detection Techniques and Applications
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
Okayama University
2014-2025
Nagoya University
2016-2025
National Institute for Fusion Science
2024-2025
Tokai National Higher Education and Research System
2024-2025
National Hospital Organization Takasaki Medical Center
2024
The University of Tokyo
2015-2024
Gunma University Hospital
2024
Wakayama University
2024
Ibaraki University
2020
Keio University Hospital
2020
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, in precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten early tumors, which contained adenoma and carcinoma situ. By comparing with data from advanced we show that the tumors accumulate a higher proportion of subclonal driver mutations than is highlighted KRAS APC. also demonstrate variant allele frequencies tend to be suggesting are...
An increasingly recognized component of resistance to tyrosine kinase inhibitors (TKI) involves persistence a drug-tolerant subpopulation cancer cells that survive despite effective eradication the majority cell population. Multiple groups have demonstrated these persister undergo transcriptional adaptation via an epigenetic state change promotes survival. Because this mode TKI drug tolerance appears involve addiction specific genes and pathways, we hypothesized systematic functional...
Abstract There has been accumulating evidence for the clinical benefit of chemoradiation therapy (CRT), whereas mechanisms in CRT-recurrent clones derived from primary tumor are still elusive. Herein, we identified an aberrant BUB1B/BUBR1 expression bladder cancer (BC) by comprehensive proteomic analysis. BC cells exhibited a cell-cycle-independent upregulation rendering enhanced DNA repair activity response to double-strand breaks (DSBs). With analyses employing CRISPR/cas9 system, revealed...
Background: Late-onset preeclampsia (LO-PE) poses substantial risks to maternal–fetal health yet remains more challenging predict than early-onset (PE), partly due its stronger association with maternal factors such as obesity and chronic hyper-tension. Methods: We leveraged cell-free RNA (cfRNA) sequencing of plasma in 48 samples—comprising PE, late-onset corresponding control groups—to identify LO-PE–specific biomarkers. Differential expression analyses elastic net regression were used...
Ageing is a complex process that involves interorgan and intercellular interactions. To obtain clear understanding of ageing, cross-tissue single-cell data resources are required. However, complete resource for humans not available. bridge this gap, we developed HuTAge, comprehensive integrates age-related information from The Genotype-Tissue Expression project with Tabula Sapiens to provide human tissue- cell-specific ageing molecular information. HuTAge implemented within an R Shiny...
Abstract Background Robotic needle insertion under CT guidance has been developed, but data on comparison with manual are still lacking. Purpose To compare robotic versus for fluoroscopy-guided intervention, primarily in terms of accuracy. Materials and Methods This was a prospective study between May 2020 March 2023 at single site. The cohort comprised 22 patients undergoing (Aquilion One or Aquilion CX; Canon Medical Systems) biopsy, who were randomly allocated to either the group. robot...
Abstract Unlike most cells, cancer cells activate hypoxia inducible factor-1 (HIF-1) to use glycolysis even at normal oxygen levels, or normoxia. Therefore, HIF-1 is an attractive target in therapy. However, the regulation of during normoxia not well characterised, although Mint3 was recently found and macrophages by suppressing inhibitor, factor inhibiting (FIH-1). In this study, we analysed Mint3-binding proteins investigate mechanism which regulates HIF-1. Yeast two-hybrid screening using...
Abstract Cancer cells adapt to various stress conditions by optimizing gene expression profiles via transcriptional and translational regulation. However, whether how EXOSC9, a component of the RNA exosome complex, regulates adaptation tumorigenicity in cancer remain unclear. Here, we examined effects EXOSC9 depletion on cell growth under conditions. attenuated survival cells. Interestingly, this also decreased number P-bodies, which are messenger ribonucleoprotein particles (mRNPs) required...
Abstract Background Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with multiple genomic aberrations makes them intractable. Therefore, the pathogenesis and metabolic changes of ICC need to be understood develop new treatment strategies. We aimed unravel evolution identify ICC-specific characteristics investigate pathway associated development using multiregional sampling encompass intra- inter-tumoral...
Abstract Background Previous reports have described hiccups during general anesthesia that were possibly induced by drugs, including benzodiazepines. However, there are few of caused remimazolam. Case presentation A 75-year-old woman underwent corneal transplantation under with She presented once the effects muscle relaxants used induction wore off, which persisted even after various treatments, such as administration antipsychotic drugs. when remimazolam was terminated surgery to awaken...
Here, we find that human-induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM)-fated progenitors (CFPs) express a tetraspanin family glycoprotein, CD82, almost exclusively differentiate into CMs both in vitro and vivo. CD82 is transiently expressed late-stage mesoderm cells during hiPSC differentiation. Purified CD82+ gave rise to under nonspecific culture conditions with serum, as well vivo after transplantation the subrenal space or injured hearts mice, indicating successfully...
Two-dimensional video-based pose estimation is a technique that can be used to estimate human skeletal coordinates from video data alone. It also being applied gait analysis and in particularly, due its simplicity of measurement, it has the potential large populations. However, considered difficult completely homogenize environment settings during measurement Therefore, necessary appropriately deal with technical errors are not related biological factors interest. In this study, by analyzing...
Multi-regional sequencing provides new opportunities to investigate genetic heterogeneity within or between common tumors from an evolutionary perspective. Several state-of-the-art methods have been proposed for reconstructing cancer trees based on multi-regional data develop models of evolution. However, there few studies comparisons a set trees. We propose clustering method (phyC) trees, in which sub-groups the are identified topology and edge length attributes. For interpretation, we also...
“Black silicon” layers were formed by catalytic etching of Au/Si(100) wafers in HF−H2O2−H2O solutions at room temperature. The structural and optical properties the catalytic-etched Si investigated scanning electron microscopy (SEM), wettability observations, Fourier-transform infrared (FTIR) spectroscopy analysis, near-IR−UV transmittance, Raman scattering, photoluminescence (PL), PL excitation, decay measurements. SEM observation suggested that vertically well-aligned nanowires can be...