A5102870674- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Glycosylation and Glycoproteins Research
- Pediatric health and respiratory diseases
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Otitis Media and Relapsing Polychondritis
- Colorectal Cancer Screening and Detection
- Public Health and Nutrition
- Asthma and respiratory diseases
- Ocular Diseases and Behçet’s Syndrome
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Metastasis and carcinoma case studies
Oita University
2016-2025
The University of Tokyo
2019-2025
University of Tokyo Hospital
2023
Oita University Hospital
2018
Japanese Red Cross Medical Center
2015-2017
Background/Objectives: Although Helicobacter pylori (H. pylori) eradication therapy is important for preventing gastric cancer (GC), the occurrence of GC after H. remains a problem. In this study, aim was to identify risk factors by comparing long-term histological, endoscopic, and serological evaluations patients with without GC. Methods: Patients who underwent at Oita University Hospital between June 1997 August 2013 were followed least 3 years endoscopy, histology, serum biochemical tests...
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, in precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten early tumors, which contained adenoma and carcinoma situ. By comparing with data from advanced we show that the tumors accumulate a higher proportion of subclonal driver mutations than is highlighted KRAS APC. also demonstrate variant allele frequencies tend to be suggesting are...
INTRODUCTION: During the coronavirus disease 2019 pandemic, whether endoscopy generates aerosols needs to be determined. METHODS: In patients undergoing upper gastrointestinal with an enclosure covering their heads, 0.3–10-μm were measured for 60 seconds before, during, and after by optical counter. Whether increased in situation without was examined. RESULTS: The analysis included 103 consecutive 90 control patients. Aerosols significantly during compared group. Body mass index burping...
This study presents a novel two stage deep learning algorithm for automated detection of mucus plugs in CT scans patients with respiratory diseases. Despite the clinical significance COPD and asthma where they indicate hypoxemia, reduced exercise tolerance, poorer outcomes, remain under evaluated practice due to labor intensive manual annotation. The developed first segments both patent obstructed airways using VNet-based model pre-trained on normal airway structures fine-tuned containing...
We aimed to determine whether linked color imaging (LCI), a new image-enhanced endoscopy that enhances subtle differences in mucosal colors, can distinguish the border of endoscopic atrophy. This study included 30 patients with atrophic gastritis. In endoscopy, we continuously took images same composition both LCI and white light (WLI). each image, values nonatrophic mucosae were quantified using International Commission on Illumination 1976 (L∗, a∗, b∗) space. Color at border, defined as...
Patient-derived tumor organoids have considerable potential as an in vitro diagnostic tool for drug susceptibility testing. In the present study, we investigated whether bile collected purposes could be a source establishment of biliary cancer organoids. Among 68 cases cancer, successfully generated 60 bile-derived (BDOs) from individual patients. Consistent with previous reports that described surgical tissues, BDOs showed diverse morphologies such simple cysts, multiloculated thick...
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor with dismal prognosis. Recently, molecular subtypes of SCLC have been defined by the expression status ASCL1, NEUROD1, YAP1, and POU2F3 transcription regulators. ASCL1 essential for differentiation expressed in majority SCLC. Although previous studies investigated target genes cells, ASCL1-mediated regulation miRNAs its relationship to remain poorly explored. Here, we performed genome-wide profiling chromatin...
Improvement of atrophic gastritis and intestinal metaplasia (IM) is considered to reduce the gastric cancer risk, but whether it can be achieved by H. pylori eradication (HPE) remains controversial. To evaluate effect HPE, we observed mucosa for up to17 years after HPE sex differences in mucosa.In total, 172 patients (94 males, 78 females) with were enrolled. Annual histological evaluations performed 17 years. The grades mononuclear cells, neutrophils, atrophy, IM antrum corpus evaluated...
Helicobacter pylori (H. pylori) infection has been clearly shown to be a cause of gastric cancer, and the incidence cancer decrease with eradication. However, few reports have described utility eradication therapy in elderly people. Thus, an investigation focusing on how much actual histological improvement is obtained people was conducted.This retrospective study conducted using medical information patients diagnosed H. pylori-associated gastritis who underwent therapy. The assessed based...
Abstract Background Persistent Helicobacter pylori infection induces gastric mucosal atrophy, which is a precancerous condition. Hydrogen sulfide (H 2 S), gaseous biological transmitter, has been implicated in both the physiological functions of gastrointestinal tract and its diseases. To understand epithelial cell response against H infection, we investigated metabolic changes cancer cells co‐cultured with observed modulation endogenous S production. Materials Methods Gastric AGS were an...
Tocilizumab, a humanized anti-interleukin-6 (IL-6) receptor monoclonal antibody, is used for the treatment of adult-onset Still disease (AOSD). Despite its efficacy in many clinical situations, concerns have been raised regarding intestinal mucosal injury patients receiving tocilizumab.A 64-year-old woman with history AOSD was admitted to our hospital hematochezia. She had 15 years and underwent biweekly tocilizumab 9 months prior admission. Colonoscopy revealed large punched-out ulcer...
CyberKnife® (CK) is a new, advanced radiotherapy technique. This study aimed to evaluate its efficacy and toxicity in Japanese patients with early-stage primary lung tumor who were medically unfit inoperable.This retrospective investigated received CK treatment for inoperable Stage І at the Red Cross Medical Center between June 2011 September 2016. Each patient total of 36-48 Gy (median, 43 Gy) administered by 4-5 fractions.Totally, 40 (T1a, n = 19; T1b, 15; T2a, 6) included. Their median...
A 54-year-old man was treated with mycophenolate mofetil (MMF) after undergoing living donor renal transplantation. Two years later, he experienced repeated episodes of diarrhea, and his C-reactive protein (CRP) level found to be 12.63 mg/dL. Ileocolonoscopy showed multiple deep, punched-out ulcers that were similar Behçet's disease (BD) cytomegalovirus (CMV) in the ileum. CMV infection suspected. However, anti-cytomegalovirus agents ineffective. The patient subsequently diagnosed...
Stratification of gastric cancer risk by measuring serological biomarkers is useful for screening cancer. However, this method has problem such as overlooking past infected patients. We aimed to evaluate the association between Helicobacter pylori infection status and biomarkers. divided 5,268 patients according were into 12 groups time elapsed since eradication. analyzed mean serum H. immunoglobulin G antibody, pepsinogen titers, histological endoscopic atrophy score each group. Mean...
Patients with chronic enteropathy associated SLCO2A1 (CEAS) develop multiple circular, longitudinal, or eccentric ulcers in the ileum. It is sometimes difficult to distinguish CEAS from Crohn's disease. and primary hypertrophic osteoarthropathy (PHO) are together known be caused by a mutation of gene. The case 65-year-old man whose characteristic appearance due pachydermia forehead folds led diagnosis PHO presented.
Background/Aims Although undifferentiated gastric cancer (UGC) diagnosed after Helicobacter pylori eradication (HPE) carries a poor prognosis, characteristics of post-HPE UGC have not been evaluated in detail because its low incidence. Therefore, we compared the clinicopathologic and differentiated cancers (DGC) successful HPE. Methods GC lesions from patients who had successfully completed HPE undergone upper gastrointestinal endoscopy between January 2004 March 2016 were analyzed. Tumors...
Although some studies have indicated a correlation between Helicobacter pylori infection and the risk of colorectal neoplasms, these findings not been consistent are controversial. This case-control study aimed to investigate association endoscopic gastric mucosal atrophy polyp occurrence. Records 7,394 participants who underwent colonoscopy examinations from August 2008 July 2018 were reviewed retrospectively. A total 2,404 subjects registered; 1,565 (65.1%) in atrophy-positive group 1,138...
The aim of this study was to assess the efficacy esomeprazole-based triple therapy compared with rabeprazole-based according CYP2C19 genotype and clarithromycin susceptibility status for first-line eradication Helicobacter pylori (H. pylori) in Japan. We enrolled 219 H. pylori-infected patients, randomly allocated patients EAC group (esomeprazole 20 mg, 200 amoxicillin 750 mg one week, all drugs given twice daily) or RAC (rabeprazole 10 daily). rate PP analyses 75.0% (95% CI: 65.2-82.8%)...
Epithelial-mesenchymal transition (EMT) is a cellular process during which epithelial cells acquire mesenchymal phenotypes. Cancer undergo EMT to malignant features and TGF-β key regulator of EMT. Here, we demonstrate for the first time that could elicit in mouse lung adenocarcinoma cell line. signaling activation led morphological changes corresponding enhanced expression markers EMT-associated transcription factors CMT64 cancer cells. RNA-sequencing analyses revealed increases Tead an...