A5038695535- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Medical Imaging and Pathology Studies
- Structural Analysis and Optimization
- Metastasis and carcinoma case studies
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Urban and spatial planning
- Airway Management and Intubation Techniques
- IL-33, ST2, and ILC Pathways
- Structural Load-Bearing Analysis
- Lung Cancer Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Frailty in Older Adults
- Adenosine and Purinergic Signaling
- Pediatric health and respiratory diseases
- Transplantation: Methods and Outcomes
- Vasculitis and related conditions
The University of Tokyo
2012-2025
Higashihiroshima Medical Center
2018-2022
Tokyo Institute of Technology
2018-2021
Nikken Sekkei (Japan)
1996-2021
University of Tokyo Hospital
2021
Eli Lilly (Japan)
2020
GlaxoSmithKline (Japan)
2020
Asahi Kasei (Japan)
2020
Tokyo Medical Center
2020
Kure Medical Center
2009-2018
Aging is a significant risk factor for autoimmunity, and many autoimmune diseases tend to onset during adulthood. We conducted an extensive analysis of CD4
Carbon monoxide (CO), an endogenous cytoprotective product of heme oxygenase type-1 regulates target thrombotic and inflammatory genes in ischemic stress. Regulation the gene encoding early growth response 1 (Egr-1), a potent transcriptional activator deleterious cascades, may govern CO-mediated lung protection. The exact signaling mechanisms underlying cytoprotection are not well understood. In this study we tested hypothesis that inhibition mitogen-activated protein kinase-dependent Egr-1...
Abstract Allergic airway inflammation is generally considered a Th2-type immune response. Recent studies, however, demonstrated that Th17-type responses also play important roles in this process, especially the pathogenesis of neutrophilic inflammation, hallmark severe asthma. We previously reported dendritic cells release dopamine to naive CD4+ T Ag-specific cell–cell interaction, turn inducing Th17 differentiation through D1-like receptor (D1-like-R). D1-like-R antagonist attenuates...
Allergic inflammation in the airway is generally considered a Th2-type immune response. However, Th17-type responses also play important roles this process, especially pathogenesis of severe asthma. IL-22 cytokine and thus might development allergic inflammation. There increasing evidence that can act as proinflammatory or anti-inflammatory depending on inflammatory context. its role Ag-induced not well understood. This study examined whether could suppress mechanism action. BALB/c mice were...
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Abstract Background Ensitrelvir is a novel SARS-CoV-2 3-chymotrypsin-like protease inhibitor, similar to nirmatrelvir/ritonavir. Several case reports have demonstrated the efficacy of inhibitors in treating prolonged coronavirus disease 2019 (COVID-19) immunocompromised patients. Tacrolimus (TAC) widely used immunosuppressive agent whose blood level can increase significantly due inhibition cytochrome P450 3A (CYP3A) and P-glycoprotein by Since ensitrelvir also inhibits CYP3A P-gp,...
Hepatocyte growth factor (HGF) plays an important role in angiogenesis, cell proliferation, antifibrosis, and antiapoptosis. Moreover, recent studies have highlighted the immunosuppressive effect of HGF animal models allogenic heart transplantation autoimmune myocarditis vitro as well. We also reported that significantly suppresses dendritic function, thus down-regulating Ag-induced Th1-type Th2-type immune responses allergic airway inflammation. However, many other situations has not been...
Statins are widely used to treat hyperlipidaemia. Their immunosuppressive effect has recently been confirmed in various immune mediated disease models. However, relatively few studies have conducted on allergic inflammation, so the precise mechanisms of their actions against allergies not fully clarified. On other hand, role interleukin (IL)17 responses highlighted, but whether statins affect IL17 production well studied. The pravastatin airway inflammation a mouse model was examined...
To decrease the risk of postoperative complication, improving general and pulmonary conditioning preoperatively should be considered essential for patients scheduled to undergo lung surgery.The aim this study is develop a short-term beneficial program preoperative rehabilitation cancer patients.From June 2009, comprehensive (CHPR) including intensive nutritional support was performed prospectively using multidisciplinary team-based approach. Postoperative complication rate transitions...
Objectives: Acute or subacute exacerbations are recognized as a severe complication of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Nevertheless, the role intensive immunosuppression in RA-ILD remains elusive. We attempted to evaluate clinical characteristics and efficacy immunosuppressive treatment exacerbated RA-ILD. Methods: Clinical data, including respiratory function, imaging, treatment, prognosis, were retrospectively collected for 17 patients with who required...
高力ボルトの高強度化の必要性は大きいのであるが,その遅れ破壊はいまだ理論的な解明がなされておらず,その必要十分な予測ができない現状にある。そのために,実験室的に耐遅れ破壊特性の優れた高強度高力ボルトであっても,容易に実用化できない。本研究は,この課題解決のために行ったもので,得た結論の要点は以下のものである。鋼中の微量水素の定量化を可能にし,試験片中の水素量とその遅れ破壊との関連を求め,一定の応力状態(P/Pf=一定)では各鋼材固有の限界水素量HTが存在することを確かめた。この試験で求められる対象鋼材の限界水素量HTは,別途水素モニターによる対象鋼材の使用環境における侵入水素量あるいは侵入の容易さを知ることによって,対象鋼材の実環境における耐遅れ破壊特性が評価できると考えた。この考えを基に,鋼材の新しい遅れ破壊特性促進評価法を提案した。
Riboflavin is a well-known nutritional supplement that has been shown to exhibit antioxidant properties and protect tissue from oxidative damage. We hypothesized riboflavin given during cardiac ischemia-reperfusion (I/R) might reduce subsequent acute rejection, after allotransplantation, coronary allograft vasculopathy (CAV).A murine heterotopic transplantation model was used test whether improves I/R injury acute/chronic rejection.Riboflavin significantly reduced oxidant production...
Allergic inflammation in the airway is generally considered a Th2-type immune response. However, recent studies demonstrated that Th1- and Th17-type responses also play important roles this process. IFN-gamma Th1-type cytokine counteracts Th2 Although previous suggest exogenous suppresses allergic inflammation, mechanism of suppression has not been fully clarified. In study, we elucidated whether Ag-induced including production cytokines lung, examined its action. BALB/c mice were sensitized...
Successful treatment with tocilizumab in a case of Cogan's syndrome complicated aortitis Get access Mihoko Shibuya, Shibuya Department Allergy and Rheumatology, Graduate School Medicine, The University Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan Correspondence to: e-mail: shimu-tky@umin.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Keishi Fujio, Fujio Kaoru Morita, Morita Hiroaki Harada, Harada Hiroko Kanda, Kanda Kazuhiko Yamamoto Modern Volume 23,...
There are multiple drivers of leukocyte recruitment in lung allografts that contribute to lymphocytic bronchitis (LB) and bronchiolitis obliterans (BO). The innate mechanisms driving (or inhibiting) trafficking remain incompletely understood. This study tested the hypothesis CD73 (ecto-5'nucleotidase), an enzyme catalyzes conversion AMP adenosine, is a critical negative regulator LB BO. Implantation tracheal from wild type (WT) mice into CD73(-/-) recipients revealed striking increase airway...
A 69-year-old man with sensorineural hearing loss and iritis was diagnosed atypical Cogan's syndrome. He had several systematic manifestations: aortitis, meningitis, panniculitis seronegative arthritis. Remission induced by treatment high doses of prednisolone followed relapse within 1 year. Although his condition resistant to various immunosuppressive drugs, including methotrexate, cyclosporine, azathioprine adalimumab, symptoms, inflammatory response quality life measures were successfully...
Food allergy is immediate hypersensitive reactions to ingested foods. Since early diagnosis effective for disease control, development of an objective diagnostic index required. Using mediator-lipidomics, we found that levels the urinary prostaglandin D2 (PGD2) metabolite, tetranor-PGDM, reflected severity allergic symptoms and intestinal mast cell hyperplasia in mice. Repeated oral challenges with ovalbumin promoted sensitized Particularly, mice presented increased numbers cells, which...
Obliterative bronchiolitis (OB) develops insidiously in nearly half of all lung transplant recipients. Although typically preceded by a CD8+ T cell–rich lymphocytic bronchitis, it remains unresponsive to conventional immunosuppression. Using an airflow permissive model study the role gases flowing over transplanted airway, is shown that prolonged inhalation sublethal doses carbon monoxide (CO), but not nitric oxide (NO), obliterate appearance obstructive airway lesion. Induction enzyme...
Abstract BACKGROUND: Even after early detection and curative resection of stage non–small cell lung cancer (NSCLC), a significant fraction patients develop recurrent disease. Molecular biomarkers that can predict the risk recurrence thus need to be identified improve clinical outcomes. METHODS: Using methylation‐specific polymerase chain reaction assay, promoter methylation breast susceptibility gene 1 ( BRCA1 ) was assessed in tissues from 70 with curatively resected I NSCLC. The relevance...
Bisphosphonates (BPs) have been widely used to treat osteoporosis. They act by inhibiting farnesyl diphosphate synthase in the mevalonate pathway. This resembles action of statins, whose immune-modulating effect has recently highlighted. In contrast, BPs on immune responses not elucidated well. this study, we examined alendronate (ALN), a nitrogen-containing BP, allergic airway inflammation mouse model. BALB/c mice were sensitized twice with OVA and challenged three times nebulized induce...