A5056268573- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Liver Diseases and Immunity
- Rheumatoid Arthritis Research and Therapies
- Viral-associated cancers and disorders
- Autoimmune Bullous Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- IgG4-Related and Inflammatory Diseases
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
The University of Tokyo
2020-2025
Kumamoto University
2023
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immune cells. To elucidate SLE pathogenesis, it essential to understand the dysregulated gene expression pattern linked various clinical statuses with high cellular resolution. Here, we conducted large-scale transcriptome study 6,386 RNA sequencing data covering 27 cell types from 136 and 89 healthy donors. We profiled two distinct cell-type-specific transcriptomic signatures: disease-state disease-activity...
Aging is a significant risk factor for autoimmunity, and many autoimmune diseases tend to onset during adulthood. We conducted an extensive analysis of CD4
Despite the involvement of B cells in pathogenesis immune-mediated diseases (IMDs), biological mechanisms underlying their function are scarcely understood. To overcome this gap, here we constructed and investigated a large-scale repertoire catalogue five cell subsets patients with IMDs.We mapped receptor regions from RNA sequencing data sorted subsets. Our dataset consisted 595 donors under IMDs health. We characterised features various aspects, including association immune transcriptomes...
B cells play a crucial role in the immune response and contribute to various autoimmune diseases. Recent studies have revealed abnormalities cell receptor (BCR) repertoire of patients with diseases, distinct features observed among different diseases subsets. Classically, BCR was used as an identifier antigen-specific clonotypes, but recent advancement analyzing large-scale has enabled us use it tool for characterizing cellular biology. In this review, we provide overview incorporating...
CD4+ T cell plasticity plays a pivotal role in immune homeostasis. However, evidence of and its pathological human systemic lupus erythematosus (SLE) is missing due to the lack reporter system. Here we utilized receptor (TCR) repertoire data as molecular signatures alongside transcriptomic dataset. Using large-scale ImmuNexUT database autoimmune disease patients including 117 SLE cases, quantified across 13 fine-grained cell-types. We analyzed 6,392 samples total identified two orthogonal...
To explore the relationship between physique and immunological disturbances in systemic lupus erythematosus (SLE), we analyzed clinical, transcriptomic characteristics of patients with SLE relation to body mass index (BMI). Clinical were obtained from patient charts, serum cytokine levels measured. Phenotypes transcriptomes peripheral immune cells ImmuNexUT database BMI. Thirty-four included analysis. Fever mucocutaneous symptoms commonly observed a low BMI was negatively correlated disease...
Abstract Objective The objective of this study was to stratify patients with MCTD, based on their immunophenotype. Methods We analysed the immunophenotype and transcriptome 24 immune cell subsets [from SLE, idiopathic inflammatory myopathy (IIM) SSc] from our functional genome database, ImmuNexUT (https://www.immunexut.org/). MCTD were stratified by employing machine-learning models, including Random Forest, trained immunophenotyping data IIM SSc patients. transcriptomes gene set variation...
Abstract Objectives Unravelling the mechanisms underlying treatment response for targeted therapeutics in systemic lupus erythematosus (SLE) patients is challenging due to limited understanding of diverse responses circulating immune cells, particularly B cells. We investigated lymphocyte dynamics during anti-BAFF treatment, utilizing longitudinal single-cell transcriptome data. Methods conducted RNA sequencing on peripheral blood mononuclear cells (PBMCs) four Korean SLE before and after...
Janus kinase (JAK) inhibitors, a type of targeted synthetic disease-modifying anti-rheumatic drug (DMARD), are emerging as useful therapeutic agents for variety autoimmune diseases, including ...
Abstract Objectives Despite the involvement of B cells in pathogenesis immune-mediated diseases, biological mechanisms underlying their function are scarcely understood. To overcome this gap, here we constructed and investigated a large-scale repertoire catalog five cell subsets disease patients. Methods We mapped receptor regions from RNA sequencing data sorted subsets. Our dataset consisted 595 donors under diseases health. characterized features various aspects, including association with...
Abstract Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease involving multiple immune cells. A major hurdle to the elucidation of SLE pathogenesis our limited understanding dysregulated gene expression linked various clinical statuses with high cellular resolution. Here, we conducted large-scale transcriptome study 6,386 RNA sequencing data covering 27 cell types from 159 89 healthy donors. We first profiled two distinct cell-type-specific transcriptomic...