A5002719385- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
Seoul National University
2023-2024
Microglia, similar to peripheral macrophages, are the primary immune cells of central nervous system (CNS). Microglia exist in resting state healthy CNS, but can be activated and polarized into either M1 or M2 subtypes for defense maintenance CNS homeostasis by multiple stimuli. Several long noncoding RNAs (lncRNAs) mediate human inflammatory diseases neuropathologies regulating their target genes. However, function common lncRNAs that contribute microglial activation remains unclear. Thus,...
Abstract Objectives Unravelling the mechanisms underlying treatment response for targeted therapeutics in systemic lupus erythematosus (SLE) patients is challenging due to limited understanding of diverse responses circulating immune cells, particularly B cells. We investigated lymphocyte dynamics during anti-BAFF treatment, utilizing longitudinal single-cell transcriptome data. Methods conducted RNA sequencing on peripheral blood mononuclear cells (PBMCs) four Korean SLE before and after...