A5056838376- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- T-cell and B-cell Immunology
- Radical Photochemical Reactions
- Monoclonal and Polyclonal Antibodies Research
- Vasculitis and related conditions
- Drug-Induced Hepatotoxicity and Protection
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Organic Chemistry Cycloaddition Reactions
- Chemical Reactions and Mechanisms
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Heterotopic Ossification and Related Conditions
- Otitis Media and Relapsing Polychondritis
- Metabolism and Genetic Disorders
- Sulfur Compounds in Biology
- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Immunodeficiency and Autoimmune Disorders
- Osteomyelitis and Bone Disorders Research
- Photochemistry and Electron Transfer Studies
- Bone health and treatments
The University of Tokyo
1967-2024
National Center for Global Health and Medicine
2017-2019
Center for Global Health
2017
University of Electro-Communications
1987-1997
Seikei University
1996
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immune cells. To elucidate SLE pathogenesis, it essential to understand the dysregulated gene expression pattern linked various clinical statuses with high cellular resolution. Here, we conducted large-scale transcriptome study 6,386 RNA sequencing data covering 27 cell types from 136 and 89 healthy donors. We profiled two distinct cell-type-specific transcriptomic signatures: disease-state disease-activity...
Little is known about the immunology underlying variable treatment response in rheumatoid arthritis (RA). We performed large-scale transcriptome analyses of peripheral blood immune cell subsets to identify cells that predict resistance.We isolated 18 55 patients with RA requiring addition new and 39 healthy controls, RNA sequencing. Transcriptome changes effects were systematically characterised. Association between gene modules resistance was evaluated. validated predictive value identified...
Idiopathic inflammatory myopathies (IIM) demonstrate characteristic clinical phenotypes depending on the myositis-specific antibody (MSAs) present. We aimed to identify common or MSA-specific immunological pathways in different immune cell types from peripheral blood by transcriptome analysis.We recruited 33 patients with IIM who were separated into following groups: 15 active disease at onset and 18 inactive under treatment. All positive for MSAs: anti-melanoma differentiation-associated...
Recent advances in single-cell RNA sequencing technology have improved our understanding of the immunological landscape rheumatoid arthritis (RA). We aimed to stratify synovium from East Asian patients with RA by immune cell compositions and gain insight into inflammatory drivers each synovial phenotype.Synovial tissues were obtained Japan (n = 41) undergoing articular surgery. The cellular composition was quantified a deconvolution approach using public single-cell-based reference....
We evaluated flow-cytometric and transcriptome features of peripheral blood immune cells from early-phase (disease duration <5 years) SSc in comparison with late-phase SSc.Fifty Japanese patients (12 early cases 38 late cases) 50 age- sex-matched healthy controls were enrolled. A subset proportions RNA-sequencing 24 cell subsets was performed. differentially expressed genes (DEGs), characterized the co-expressed gene modules, estimated composition subpopulations by deconvolution based on...
Hepatic steatosis was induced in rats by feeding nutritionally adequate liquid diet containing ethanol as 36% of energy for 4-5 weeks. After 24 h fasting and withdrawal from ethanol, liver ischaemia 30 min followed 2 reperfusion resulted a significant increase microsomal lipid peroxide content decrease reduced glutathione well protein synthesis with rapid accumulation triglyceride the liver. In fed non-ethanol or those high-cholesterol hepatic steatosis, however, similar phenomena were not...
When rats received dimethylnitrosamine every 24 h until death, plus hormone treatment after the first h, survival was enhanced between 100 and 140 compared with control rats, attenuated derangements of prothrombin time serum albumin levels at 120 h. In given a single dose dimethylnitrosamine, hepatic DNA synthesis peaked 48 The increased when started immediately, but not delayed for Hormone 3 days starting produced rapid normalization decreased protein content on day 9, although affected....
is a negative regulator of T cell activation and one the key activators type I interferon (IFN) NFκB signaling via non-classical pathways. The upstream single nucleotide polymorphism
Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease marked elevation of blood eosinophil associated various symptoms in the respiratory tract, gastrointestinal peripheral nerves, and skin due to systemic vasculitis. Here, we report case EGPA which rhinosinusitis was treated endoscopic sinus surgery (ESS) good results. A 49-year-old man who developed bronchial asthma at age 48 diagnosed our hospital. Treatment prednisolone (PSL) mepolizumab relieved eosinophilia caused by...
Abstract Objectives Little is known about the immunology underlying variable treatment response in rheumatoid arthritis (RA). We performed large scale transcriptome analyses of peripheral blood immune cell subsets to identify cells that predict resistance. Methods isolated 18 55 pre-treatment RA patients and 39 healthy controls, RNA sequencing. Transcriptome changes effects were systematically characterized. Association between gene modules resistance was evaluated. validated predictive...
We report here on the first case, to our knowledge, of retro-odontoid pseudotumor (ROP) in a patient with an autoimmune disease other than rheumatoid arthritis (RA). It is possible that onset ROP was related Sjogren syndrome (SS) serology for systemic lupus erythematosus (SLE). A 34-year-old man presented without RA. Three years earlier, he had sicca symptoms and many renal splenic infarctions, diagnosed SS antiphospholipid antibody syndrome. The anti-SSA, anti-SSB, anti-dsDNA, anti-RNP,...