A5056937078- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Myopathies and Dermatomyositis
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Eosinophilic Disorders and Syndromes
- Peripheral Neuropathies and Disorders
- Cancer-related molecular mechanisms research
- Otitis Media and Relapsing Polychondritis
- Immunodeficiency and Autoimmune Disorders
- Pulmonary Hypertension Research and Treatments
- Viral-associated cancers and disorders
- Autoimmune Neurological Disorders and Treatments
- Oral and gingival health research
- interferon and immune responses
- Liver Diseases and Immunity
- Mycobacterium research and diagnosis
The University of Tokyo
2016-2025
Shimizu (Japan)
2024
Mie Chuo Medical Center
2024
University of Tokyo Hospital
2021-2023
Yamagata University Hospital
2018
National Center for Global Health and Medicine
2013-2015
Abstract Splicing quantitative trait loci (sQTLs) are one of the major causal mechanisms in genome-wide association study (GWAS) loci, but their role disease pathogenesis is poorly understood. One reason complexity alternative splicing events producing many unknown isoforms. Here, we propose two approaches, namely integration and selection, for this by focusing on protein-structure First, integrate isoforms with same coding sequence (CDS) identify 369-601 integrated-isoform ratio QTLs (i 2...
Regulatory T cells (Tregs) play a role in the suppression of inflammation autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as marker interleukin (IL)-10-producing Tregs. We aimed to clarify function human IL-10-producing CD4+CD25-LAG3+ (LAG3+ Tregs) their association with rheumatoid arthritis (RA).LAG3+ Tregs peripheral blood mononuclear (PBMCs) were cultured B follicular helper examine antibody effects. The frequency LAG3+ evaluated samples from 101 healthy donors...
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that leads to destructive arthritis. Although the HLA class II locus strongest genetic risk factor for rheumatoid arthritis, relationship between alleles and lymphocyte activation remains unclear. We performed immunophenotyping of peripheral blood mononuclear cells on 91 HLA-DRB1-genotyped RA patients 110 healthy donors. The frequency memory CXCR4 + CD4 T not Th1 Th17 cells, was significantly associated with...
Objectives Synovial fibroblasts (SFs) are one of the major components inflamed synovium in rheumatoid arthritis (RA). We aimed to gain insight into pathogenic mechanisms SFs through elucidating genetic contribution molecular regulatory networks under inflammatory condition. Methods from RA and osteoarthritis (OA) patients (n=30 each) were stimulated with eight different cytokines (interferon (IFN)-α, IFN-γ, tumour necrosis factor-α, interleukin (IL)-1β, IL-6/sIL-6R, IL-17, transforming...
Though the maximum energy of charged cosmic ray observations exceeds 100 EeV, frontier gamma-ray is PeV. In past years, Tibet AS𝛾, HAWC and LHAASO opened a new window astronomy in sub-PeV to PeV range, which important unveil yet unknown accelerators our galaxy. As these 3 experiments are all located northern hemisphere, southern hemisphere have been awaited. Andes Large area PArticle detector for Cosmic physics Astronomy (ALPACA) air shower array experiment under construction Bolivian...
Introduction: Pulmonary hypertension (PH) is characterized by increased pressure in the pulmonary artery and right ventricular hypertrophy (RVH). Recently, angiotensin-converting enzyme 2 (ACE2), which converts angiotensin (Ang) II into Ang-(1-7), was shown to inhibit experimental PH. Here we identified a novel ACE2 activator investigated how compound reduced monocrotaline (MCT)-induced Methods: To induce PH, Sprague-Dawley rats were injected subcutaneously with MCT, followed continuous...
Rapidly progressive interstitial lung disease (ILD) associated with clinically amyopathic dermatomyositis (CADM) is often lethal despite corticosteroid therapy combined cyclophosphamide and cyclosporine or tacrolimus. Several recent studies have described the treatment of ILD in patients systemic sclerosis (SSc) other connective tissue diseases mycophenolate mofetil (MMF), a non-cytotoxic immunosuppressant [1–9]. To our knowledge, this first report MMF as an alternative to intravenous pulses...
Journal Article Successful tocilizumab therapy in seven patients with refractory adult-onset Still's disease Get access Ei Bannai, Bannai Division of Rheumatic Diseases, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan Search other works by this author on: Oxford Academic Google Scholar Hiroyuki Yamashita, Yamashita Correspondence to: 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan. Tel: + 81-3-3202-7181. Fax: 81-3-3207-1038. E-mail: hiroyuki_yjp2005@yahoo.co.jp...
TGF-β is a pleotropic cytokine involved in various biological processes. Of the three isoforms of TGF-β, TGF-β1 has long been recognized as an important inhibitory immune system and reported to inhibit B cell function both mice humans. Recently, it suggested that TGF-β3 may play role regulation mice. Murine CD4+CD25-LAG3+ regulatory T cells suppress through production TGF-β3, therapeutic mouse model systemic lupus erythematosus. The effect on human not reported, we herein examined cells....
Abstract HLA-DRB1 shared epitope risk alleles are the strongest genetic factors for rheumatoid arthritis (RA) and potential biomarkers treatment response to biological disease-modifying antirheumatic drugs (bDMARDs). This study aimed investigate association between individual in RA patients receiving different bDMARDs. We recruited 106 with active who had started abatacept, tocilizumab, or TNF inhibitors as a first-line examined relationship Simplified Disease Activity Index (SDAI)...
Objective. The gamma-aminobutyric acid type B receptors (GABARB) are G-protein coupled for GABA, the main inhibitory neurotransmitter in brain. We identified GABARB subunits as candidate antigens patients with SLE using a random peptide display library. aim of this study was to investigate possible link between anti-GABARB antibodies and disease activity NPSLE.
Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple immune cell subsets. We analyzed subsets in human peripheral blood mononuclear cells (PBMC) order to identify the are significantly associated with SLE activity and treatment. The frequencies of various CD4+ T cells, B monocytes NK PBMC were assessed 30 healthy controls (HC), rheumatoid arthritis (RA) patients 26 using flow cytometry. correlations between subset clinical traits including Lupus Erythematosus...
Recent advances in single-cell RNA sequencing technology have improved our understanding of the immunological landscape rheumatoid arthritis (RA). We aimed to stratify synovium from East Asian patients with RA by immune cell compositions and gain insight into inflammatory drivers each synovial phenotype.Synovial tissues were obtained Japan (n = 41) undergoing articular surgery. The cellular composition was quantified a deconvolution approach using public single-cell-based reference....
Journal Article Characteristics of 10 patients with paraneoplastic rheumatologic musculoskeletal manifestations Get access Hiroyuki Yamashita, Yamashita Division Rheumatic Diseases, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan Correspondence to: 1-21-1 Toyama, Shinjuku, 162-8655 Japan. Tel: + 81-3-3202-7181. Fax: +81-3-3207-1038. E-mail:hiroyuki_yjp2005@yahoo.co.jp Search other works by this author on: Oxford Academic Google Scholar Yo Ueda, Ueda Takashi Ozaki,...
Chronic active Epstein-Barr virus infection (CAEBV) is characterized by chronic infectious mononucleosis-like symptoms. We report a very rare case with autoimmune hepatitis (AIH) complicated CAEBV. A 50-year-old woman systemic lupus erythematosus (SLE) AIH began to suffer from acute respiratory failure and her clinical symptoms improved rapidly in response steroid treatment. However, during the gradual tapering of dose, steady increase serum hepatobiliary enzyme levels subsequently was...
Clinically amyopathic dermatomyositis (CADM) patients frequently develop refractory interstitial lung disease (ILD), with a poor prognosis. We aimed to verify the efficacy and safety of plasma exchange (PE) treatment for ILD in CADM.A retrospective case-control study was conducted compare clinical outcomes without PE CADM-ILD combination therapy high-dose glucocorticoids, calcineurin inhibitors, cyclophosphamide. Among 19 enrolled patients, 11 were further treated PE. compared survival rates...