A5021673902- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Platelet Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Bone health and treatments
- Bone and Joint Diseases
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Peripheral Neuropathies and Disorders
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Lymphoma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Medical Imaging and Pathology Studies
- Renal Diseases and Glomerulopathies
- Autophagy in Disease and Therapy
Hokkaido University
2016-2025
Hokkaido University Hospital
2010-2023
Feinstein Institute for Medical Research
2015-2017
National Institute of Technology, Tomakomai College
2017
Tokyo Women's Medical University
2012
Obihiro Kosei General Hospital
2008
Abstract Objective To define the antiphospholipid score (aPL‐S) by testing multiple antibodies (aPL) and to evaluate its efficacy for diagnosis of syndrome (APS) predictive value thrombosis. Methods This study comprised 2 independent sets patients with autoimmune diseases. In first set (n = 233), aPL profiles were analyzed. Five clotting assays lupus anticoagulant 6 enzyme‐linked immunosorbent (IgG/IgM anticardiolipin antibodies, IgG/IgM anti–β ‐glycoprotein I, phosphatidylserine‐dependent...
Abstract Dysregulation of Th17 and Treg cells contributes to the pathophysiology many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite, inhibits cell differentiation promotes by orchestrating metabolic epigenetic reprogramming. Mechanistically, itaconate suppresses glycolysis oxidative phosphorylation in Th17- Treg-polarizing T cells. Following treatment with S-adenosyl-L-methionine/S-adenosylhomocysteine ratio 2-hydroxyglutarate levels are decreased...
Objective. Interstitial lung diseases (ILDs) complicated with PM or DM are frequently aggressive and refractory to treatment. Recently some reports have suggested the potential benefit of tacrolimus for severe ILD PM/DM. However, little evidence has yet shown efficacy in these settings. The aim this study was evaluate as a treatment PM-/DM-related ILD. Methods. This retrospective comprised 49 previously untreated patients diagnosed admitted Hokkaido University Hospital from January 2000 July...
Cognitive impairment occurs in 40–90% of patients with systemic lupus erythematosus (SLE), which is characterized by autoantibodies to nuclear antigens, especially DNA. We discovered that a subset anti-DNA antibodies, termed DNRAbs, cross reacts the N-methyl-d-aspartate receptor (NMDAR) and enhances NMDAR signaling. In patients, DNRAb presence associates spatial memory impairment. mouse model, DNRAb-mediated brain pathology proceeds through an acute phase excitotoxic neuron loss, followed...
Objective IgG anti‐ DWEYS antibodies cross‐reactive with DNA and the N ‐methyl‐ d ‐aspartate receptor subunits GluN2A GluN2B are known to be associated neuropsychiatric systemic lupus erythematosus ( NPSLE ). have not been investigated in demyelinating or another disorder, neuromyelitis optica spectrum disorder NMOSD ), which is a disease also found mainly young women aquaporin 4 AQP ‐4) myelin oligodendrocyte glycoprotein MOG ) antibodies. This study was undertaken investigate frequency of...
To assess the value of a combination anti-β2 -glycoprotein I (anti-β2 GPI) domain antibody and anti-phosphatidylserine/prothrombin complex (anti-PS/PT) tests for diagnosis antiphospholipid syndrome (APS).This cross-sectional study involved cohort patients who visited our clinic from April 2005 to March 2013. Tests GPI antibodies, IgG anti-PS/PT IgM together with criteria-defined antibodies (aPL), were performed in all patients. The total score (aPL-S) was calculated each patient according...
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis involving asthma, peripheral eosinophilia, and multiorgan small-vessel vasculitis. We present case of EGPA eosinophilic cellulitis, highlighting significant association between these conditions.
Objective To study the classification performance of a pre-trained convolutional neural network (CNN) with transfer learning by artificial joint ultrasonography images in rheumatoid arthritis (RA). Methods This retrospective focused on abnormal synovial vascularity and created 870 ultrasound based European League Against Rheumatism/Outcome Measure Rheumatology scoring system. One CNN, Visual Geometry Group (VGG)-16, was trained using for initial training original plus five additional second...
Objective: To study the clinical and immunological manifestations of antiphospholipid syndrome (APS) in Japanese population by a single-centre registration. Methods: In this retrospective cohort study, 141 consecutive patients with APS, fulfilling Sydney revised Sapporo criteria for definite who visited our autoimmune clinic from 1988 to 2010, were recruited followed up. All interviewed underwent general physical examination qualified rheumatologists on day blood sampling. Results: The...
To evaluate the risk of reactivation resolved hepatitis B virus (HBV) by immunosuppressive therapy in patients with autoimmune diseases.Thirty-five diseases were included our study; all surface antigen (HBsAg)-negative and antibody against core antigen-positive. They followed for 8-124 weeks clinical outcomes analyzed, including serum levels HBV-DNA aminotransferase every 4 during their underlying diseases. If was detected therapy, HBsAg, HBsAg (anti-HBs), e (HBeAg), HBeAg also monitored...
The objective of this study was to clarify the long-term outcome in patients with lupus nephritis (LN) according International Society Nephrology and Renal Pathology classification. This retrospective analysis comprised 186 Japanese given a diagnosis LN by renal specimen mean observation period 12 years. Primary end point defined as death or end-stage disease, standardized mortality ratios were calculated. Five presented histopathological class I, 62 II, 21 III III+V, 73 IV IV+V 25 V....
We aimed to investigate the involvement of macroautophagy/autophagy in autoimmunity rheumatoid arthritis (RA) through citrullination VIM (vimentin) and its interaction with MHC class II synovial fibroblasts (SFs). The cell surface expression B7 costimulatory molecules on SFs was analyzed by flow cytometry after treatment IFNG/IFN-γ (interferon gamma). Intracellular citrullinated autoantigens were immunoblotting using serum from anti-citrullinated peptide antibodies (ACPA)-positive patient as...
Classification criteria for antiphospholipid syndrome (APS) require IgG or IgM isotypes of the anticardiolipin (aCL) antibodies, anti-β2 glycoprotein I (anti-β2GPI) and/or lupus anticoagulant (LA) to satisfy laboratory disease definition. Over past 20 years, non-criteria antibodies (aPL) directed other proteins coagulation cascade (i.e. prothrombin phosphatidylserine-prothrombin complex) some domains β2GPI have been proposed. This task force concentrated and reviewed literature on data...
Interstitial lung disease (ILD) is a serious complication of SSc. We aimed to identify markers associated with SSc-related ILD.RNA was prepared from the peripheral blood mononuclear cells 14 SSc patients, divided into four different RNA pools according presence or absence ILD and treatment, subjected microarray analysis. Real-time quantitative PCR used confirm results in 43 42 autoimmune controls 10 healthy controls. Genomic DNA samples were collected 149 patients (70 Hokkaido 79 Tokyo) who...
Warfarin is regarded as the standard treatment for preventing thrombotic events in APS, but recurrence rate still high. Dual antiplatelet therapy (DAPT) has been shown to be effective prevention of acute coronary syndrome or stroke. The objective this study was evaluate efficacy DAPT thrombosis APS patients with history arterial thrombosis.This retrospective cohort conducted at Hokkaido University Hospital between 1990 and 2016. secondary prophylactic effects safety warfarin monotherapy...
Idiopathic osteonecrosis of the femoral head (ION) is a common complication SLE associated with CS therapy. Although pathogenesis ION involves local bone ischaemia favoured by thrombophilia, involvement aPL in lupus remains to be elucidated. We have previously reported score (aPL-S) as quantitative marker and development thrombotic events autoimmune diseases. The aim this study was identify impact on using aPL-S.This single-centre retrospective comprising 88 consecutive patients who...
Adynamic bone disease in HD patients is characterized by skeletal resistance to parathyroid hormone (PTH) or suppression of PTH release, leading a downregulated turnover and fracture. Hence, we examined the efficacy weekly teriparatide for with low indicating adynamic without history parathyroidectomy. Fifteen were recruited this prospective observational study. Of them, 10 received 12 months five nontreated enrolled as control. Primary outcomes defined changes mineral density markers. Bone...