Daigo Nakazawa
A5101937303- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Kidney Disease and Diabetes
- Amino Acid Enzymes and Metabolism
- Digestive system and related health
- Biomedical Research and Pathophysiology
- Genetic Syndromes and Imprinting
- Vasculitis and related conditions
- PARP inhibition in cancer therapy
- Bone health and osteoporosis research
- Urticaria and Related Conditions
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Bone health and treatments
- Mitochondrial Function and Pathology
- Hemophilia Treatment and Research
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Magnesium in Health and Disease
- Medical Imaging and Pathology Studies
- Pregnancy and Medication Impact
- Pediatric Urology and Nephrology Studies
- Inflammatory Myopathies and Dermatomyositis
Hokkaido University Hospital
2013-2022
Hokkaido University
2015-2021
Aizawa Hospital
2011
Adynamic bone disease in HD patients is characterized by skeletal resistance to parathyroid hormone (PTH) or suppression of PTH release, leading a downregulated turnover and fracture. Hence, we examined the efficacy weekly teriparatide for with low indicating adynamic without history parathyroidectomy. Fifteen were recruited this prospective observational study. Of them, 10 received 12 months five nontreated enrolled as control. Primary outcomes defined changes mineral density markers. Bone...
Abstract Previous studies reported conflicting results regarding an association between serum albumin concentration and the cumulative incidence of remission proteinuria in adult patients with minimal change disease (MCD). The present study aimed to clarify clinical impact relapse 108 MCD at 40 hospitals Japan, who were enrolled a 5-year prospective cohort primary nephrotic syndrome, Japan Nephrotic Syndrome Cohort Study (JNSCS). before initiation immunosuppressive treatment (IST) assessed...
症例は35歳，男性．1998年にGoodpasture症候群にて血液透析を導入されたが，ブラッドアクセストラブルのため2000年より腹膜透析に変更された．2003年12月より高P血症が原因でCa・P積が90(mg/dL)2を超え，右肩に手拳大，左臀部に小児頭大の異所性石灰化を認めるようになった．2004年10月より血液透析へ移行されたが異所性石灰化は改善しなかった．2005年2月24日に母をドナーとした生体腎移植を希望し，当院を初診．石灰化部はGaシンチで集積を認め，排膿よりメチシリン耐性黄色ブドウ球菌が検出されたことから感染を伴う石灰化と診断され，腎移植は見送られた．以後血液透析の継続，抗生剤治療を行ったが，異所性石灰化は増悪し続けたため，週22時間の長時間透析が施行された．長時間透析開始後，Ca・P積は是正され，異所性石灰化は改善し，2009年1月14日に腎移植が施行された．高度に進展した異所性石灰化は治療困難であるが，その治療として長時間透析は有用であることが示唆された．巨大な異所性石灰化が長時間透析により改善し腎移植を施行できた報告はこれまでになく，貴重な1例を経験したの...
ステロイド治療に抵抗性を示す巣状分節性糸球体硬化症（focal segmental glomerulosclerosis：FSGS）の一部の症例は遺伝子変異が関与する．症例は23歳男性．幼少期に尿蛋白を認め，腎生検でFSGSと診断された．ステロイドで加療されたが改善せず，十数年の経過で末期腎不全に至った．家族歴を有する事から遺伝子検索を行い，inverted formin 2遺伝子変異によるFSGSと診断した．
Department of Rheumatology, Endocrinology and Nephrology, Faculty Medicine Graduate School Medicine, Hokkaido University, Sapporo, Japan.
Abstract Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis that can cause end-stage renal disease. Recently, tonsillectomy combined with corticosteroid pulse (TSP) has been shown to be effective for achieving clinical remission and favorable outcome in patients IgAN. However, the standard regimen use TSP not established. Herein, we compared effect single- or triple-course steroid therapy This retrospective, observational cohort study included 122 IgAN enrolled from...