A5061470467- Antibiotic Resistance in Bacteria
- Photonic and Optical Devices
- Advancements in Photolithography Techniques
- Robotics and Automated Systems
- Urinary Tract Infections Management
- Antimicrobial Resistance in Staphylococcus
- Integrated Circuits and Semiconductor Failure Analysis
- Retinal and Macular Surgery
- Vascular Malformations Diagnosis and Treatment
- Silicon Nanostructures and Photoluminescence
- Semiconductor materials and devices
- Pediatric Urology and Nephrology Studies
- Systemic Sclerosis and Related Diseases
- Intraocular Surgery and Lenses
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Blood Pressure and Hypertension Studies
- MRI in cancer diagnosis
- Electron and X-Ray Spectroscopy Techniques
- Context-Aware Activity Recognition Systems
- Probiotics and Fermented Foods
- Glioma Diagnosis and Treatment
- Vasculitis and related conditions
- Teleoperation and Haptic Systems
- Robot Manipulation and Learning
Tohoku Medical Megabank Organization
2023-2025
Tohoku Medical and Pharmaceutical University
2022-2025
Tohoku University
2023-2025
Nagoya Institute of Technology
2023
Okayama Central Hospital
2018-2020
Nagoya University
2002-2018
Tokyo City University
2016-2017
University of Miyazaki
2017
Toyama Prefectural University
2014-2016
Gunma University
1992-2015
The conjugative plasmid pAD1 (56.7 kilobases) in Streptococcus faecalis confers hemolysin-bacteriocin (Hly-Bcn) expression and a mating response to the sex pheromone cAD1 excreted by recipient cells. We examined contribution of hemolysin pathogenicity intraperitoneally infected mice using Tn916 Tn917 insertion mutants altered expression. Strains exhibiting normal phenotype were significantly more virulent than nonhemolytic mutants. A mutant with an increased copy number which gave rise...
Hemolysin production, clumping (pheromone) response, transferability of the hemolytic trait, and drug resistance were examined in 97 clinical isolates Enterococcus (Streptococcus) faecalis. The derived from various sources (i.e., urine, pus, vagina, sputum, bile, blood), approximately 60% found to be hemolytic. About 85% strains exhibited a compared with about 49% nonhemolytic strains. Over 50% carried transferable hemolysin determinants, no case genes linked. multiple more frequently than...
Nephrolithiasis is a common renal disease with no effective medication. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, an anti-diabetic agent, have diuretic and anti-inflammatory properties could prevent nephrolithiasis. Here, we investigated the potential of SGLT2 inhibition against nephrolithiasis using large-scale epidemiological data, animal models, cell culture experiments. This study included data diabetic patients (n = 1,538,198) available in Japanese administrative database...
Abstract Previous studies have shown an increase in blood pressure during the coronavirus disease 2019 (COVID-19) pandemic even among patients receiving antihypertensive treatment. This study aims to evaluate association between equivalized annual household income and refraining from regular medical visits for hypertensive since COVID-19 outbreak. We analyzed data Japan Society Internet Survey (JACSIS), including 2832 aged 20–79 years 2020 survey at least one 2021 2023. They were categorized...
A derivative of the R factor NR1 (called R12) has been isolated which undergoes an increased number rounds replication each division cycle in Proteus mirabilis, Escherichia coli, and Salmonella typhimurium. The alteration resulting copies (round mutation) is associated with transfer component factor. R12 same drug resistance pattern as NR1, size shown by sedimentation a sucrose gradient electron microscopy (63 x 10(6) daltons), partial denaturation map. level gene product chloramphenicol...
The authors describe an in-pipe micro mobile robot with a new actuator called the giant magnetostrictive alloy (GMA), which requires no power supply cables. cableless robots can be controlled by magnetic fields supplied outer side. mechanism of motions is based on inch-worm-type mechanism. Two mechanisms are discussed here: (1) reversible motion and (2) one-way mechanisms. sizes 21 mm in diameter for macro model 6 model. regulated electromagnetic coil, so that follow coil. These may suitable...
Abstract A novel hybrid quantum mechanical (QM)/molecular (MM) approach that employs the real‐space grids for QM subsystem is proposed investigating chemical reactions in an aqueous condensed phase. All of Hamiltonian matrix elements including electric fields formed by point charges on MM waters represented real space. Details practical implementations are presented. The solute polarization, solvation structure, and energy a water computed, results compared with those obtained experiments...
Seven spontaneous norfloxacin (NFLX)-resistant mutants obtained in vitro from 20 NFLX-susceptible clinical isolates and 3 NFLX-resistant of Pseudomonas aeruginosa were transformed with the pNF111 plasmid, whose BamHI fragment is responsible for conferring susceptibility to NFLX, by complementing nfxB mutation. The resulting patterns MICs beta-lactams, aminoglycosides, chloramphenicol observed increased accumulation NFLX consistent occurrence type mutation these isolates.
Abstract To determine the specificity and significance of widespread attenuation glomerular basement membrane on electron microscopy, 240 renal biopsies from 218 children were studied retrospectively. Twenty‐three patients showed diffuse three them are cases hereditary nephritis. The other 20 characterized by persistent microscopic haematuria, absence proteinuria, normal blood pressure function, minimal changes. In 10 these children, haematuria was also present in family. We conclude that is...
When Proteus mirabilis harboring the R factor NR1 is cultured in Penassay broth containing 100 mug of chloramphenicol (CM) per ml, there an amplification number copies r-determinants cell. Under these conditions, factors multiple tandem sequences are formed. Autonomous poly-f-determinants consisting also This phenomenon has been referred to as "transition". Transitioned cells have considerably higher levels resistance CM and streptomycin (SM), but not tetracycline (TC), than do...
To investigate overall chromosomal alterations using array-based comparative genomic hybridisation (CGH) of myxoid liposarcomas (MLSs) and myxofibrosarcomas (MFSs).Genomic DNA extracted from fresh-frozen tumour tissues was labelled with fluorochromes then hybridised on to an array consisting 1440 bacterial artificial chromosome clones representing regions throughout the entire human genome important in cytogenetics oncology.DNA copy number aberrations (CNAs) were found all 8 MFSs, but no 7...
This study aimed to assess the combined effects of blood pressure (BP) and glucose status on chronic kidney disease (CKD) incidence in young middle-aged adults. We examined data from 1,297,341 Japanese individuals aged <60 years (60.1% men; mean age 41.4 ± 9.3 years) with no history CKD at baseline. The interval-censored Cox proportional hazards model covariates was used. During a median follow-up period 2.1 years, new onset (estimated glomerular filtration rate ml/min/1.73 m
Fractional clearances (theta) of uncharged dextrans (radii 28-60 A) were used to characterize glomerular dysfunction in 34 nephrotic humans with either minimal-change nephropathy (MCN) or focal, segmental glomerulosclerosis (FSGS). A theoretical analysis theta dextran a heteroporous membrane model revealed similar alteration, more marked FSGS than MCN. The number restrictive pores perforating the major component was reduced parallel prevailing filtration rate (GFR). Parallel shuntlike...
A pingpong robot system using a 7 degrees of freedom direct drive arm has been developed. This is composed binocular camera for measuring the position and speed ball, pitching machine, robot, controller with multi-microcomputer system. Three important techniques have developed here. First involves fast ball measurement technique camera, which two linear sensors located horizontally on focal plane each lens. Second forecasting hitting time. Third, control real time calculation inverse...
Real-space grid quantum mechanical/molecular mechanical (QM/MM) simulations have been carried out to investigate the role of water solvent on novel ethanol oxidation reaction catalyzed by two molecules through proton transfer mechanism. We considered thermodynamical conditions solutions for calculations; ambient (AW) and supercritical (SCW). The QM/MM revealed that solvation energy transition state (TS) is larger than reactant in SCW, resulting reduction activation 3.7 kcal/mol. Meanwhile,...